公开(公告)号：US20080129993A1

公开(公告)日：2008-06-05

申请号：US11876899

申请日：2007-10-23

Applicant: James F. Brennan ,  Jon Nazemi ,  Eric Marple

Inventor： James F. Brennan ,  Jon Nazemi ,  Eric Marple

IPC: G01J3/44 ,  A61B6/00

CPC classification number: G01J3/44 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/14546 ,  G01N21/65 ,  G01N2021/656

Abstract: The invention provides windowless fiber optic Raman probes that are directly or indirectly enclosed by one or more materials having a very low Raman signal in a desired wavenumber range that is used to evaluate a sample. In one embodiment, the very low Raman signal material is a polymer, such as a fluoropolymer, that has a very low Raman cross-section in the high wavenumber Raman region (approximately 2,600 to 3,200 cm−1) which has been shown to be useful in evaluating blood vessels for atherosclerotic lesions. Still another embodiment of the invention provides windowless side-viewing intravascular catheters for evaluating lumen walls such as blood vessel walls.

Abstract translation: 本发明提供了无窗光纤拉曼探针，其被一个或多个材料直接或间接包围，所述材料具有用于评价样品的所需波数范围内的非常低的拉曼信号。 在一个实施方案中，非常低的拉曼信号材料是聚合物，例如含氟聚合物，其在高波数拉曼区域（约2600至3,200cm -1）具有非常低的拉曼横截面， 已被证明可用于评估动脉粥样硬化病变的血管。 本发明的另一个实施例提供了用于评估诸如血管壁的腔壁的无窗侧视血管内导管。

公开(公告)号：US20090285538A1

公开(公告)日：2009-11-19

申请号：US12466930

申请日：2009-05-15

Applicant: Eric Marple

Inventor： Eric Marple

IPC: G02B6/04 ,  G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01N21/65 ,  G01N2021/656 ,  G02B6/262

Abstract: The invention provides miniature side-viewing fiber optic probes that achieve high collection efficiency by maximizing the overlap of a laser delivery fiber's illumination and a collection fiber's collection cone. The probes can be made with as few as one optical piece, in addition to the optical fibers. In one embodiment of the invention, the probes are configured for performing Raman spectroscopy. Spectroscopy systems utilizing the probes of the invention are also provided.

Abstract translation: 本发明提供了通过最大化激光输送纤维的照明和收集纤维收集锥的重叠来实现高收集效率的微型侧视光纤探针。 除了光纤之外，探针也可以由少至少一个光学片构成。 在本发明的一个实施例中，探针被配置用于进行拉曼光谱。 还提供了利用本发明的探针的光谱系统。