公开(公告)号：US10971324B2

公开(公告)日：2021-04-06

申请号：US15909482

申请日：2018-03-01

Applicant: Exogenesis Corporation

Inventor： Joseph Khoury ,  Sean R. Kirkpatrick ,  Michael J. Walsh ,  James G. Bachand ,  Allen R. Kirkpatrick

IPC: H01J37/05 ,  H05H3/02 ,  H01J37/317 ,  H01J37/147 ,  H05H5/04

Abstract: A device such as a medical device and a method for making same provides a surface modified by beam irradiation, such as a gas cluster ion beams or a neutral beam, to inhibit or delay attachment or activation or clotting of platelets.

公开(公告)号：US20210405523A1

公开(公告)日：2021-12-30

申请号：US17222467

申请日：2021-04-05

Applicant: Exogenesis Corporation

Inventor： Joseph Khoury ,  Sean R. Kirkpatrick ,  Michael J. Walsh ,  James G. Bachand ,  Allen R. Kirkpatrick ,  Thomas J. Webster

IPC: G03F1/80 ,  H05H3/02 ,  H01J37/317 ,  H01L21/02 ,  H01L21/265 ,  H01L21/311 ,  H01J37/05 ,  H01J37/147 ,  G03F1/82

Abstract: A device such as a medical device and a method for making same provides a device surfaces modified by beam irradiation, such as a gas cluster ion beams or a neutral beam, to inhibit or delay attachment or activation or clotting of platelets or to match surface energy of the device to that of a protein with the property of inhibition of bacterial colonization that can coat the all or part of the device surface to effect such inhibition.

公开(公告)号：US20180190468A1

公开(公告)日：2018-07-05

申请号：US15909482

申请日：2018-03-01

Applicant: Exogenesis Corporation

Inventor： Joseph Khoury ,  Sean R. Kirkpatrick ,  Michael J. Walsh ,  James G. Bachand ,  Allen R. Kirkpatrick

IPC: H01J37/05 ,  H05H3/02 ,  H01J37/317 ,  H01J37/147

CPC classification number: H01J37/05 ,  H01J37/147 ,  H01J37/317 ,  H01J37/3171 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/15 ,  H05H3/02 ,  H05H5/04 ,  Y10T428/24355 ,  Y10T428/24479 ,  Y10T428/30

Abstract: A device such as a medical device and a method for making same provides a surface modified by beam irradiation, such as a gas cluster ion beams or a neutral beam, to inhibit or delay attachment or activation or clotting of platelets.

公开(公告)号：US09839723B2

公开(公告)日：2017-12-12

申请号：US15130354

申请日：2016-04-15

Applicant: Exogenesis Corporation

Inventor： Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: A61L27/38 ,  A61L27/18 ,  A61L27/06 ,  A61L27/16 ,  A61L27/50 ,  C12N13/00

CPC classification number: A61L27/38 ,  A61L27/06 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50 ,  A61L2300/64 ,  A61L2400/18 ,  C12N13/00 ,  C08L27/18

Abstract: A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.