公开(公告)号：US20160327488A1

公开(公告)日：2016-11-10

申请号：US15215211

申请日：2016-07-20

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： Marvin R. WILLIAMS ,  Charles McBRAIRTY ,  Daniel W. PFAUTZ ,  Thomas J. ZUPANCIC ,  Lingchun ZENG ,  Andrew WEIMAN ,  Richard S. BRODY ,  Joseph D. KITTLE ,  Anthony TRUSCOTT ,  Robert BARANOWSKI

IPC: G01N21/76 ,  G01N33/569 ,  B01L3/00 ,  G01N33/02

CPC classification number: G01N21/763 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/047 ,  B01L2300/0816 ,  G01N33/02 ,  G01N33/536 ,  G01N33/56916 ,  G01N2201/0221

Abstract: A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.

Abstract translation: 一种用于快速样品分析的系统，其包括生物传感器试剂，其中所述生物传感器试剂包括活的生物细胞; 储存卡，其中储存卡存储生物传感器试剂; 以及测试盒底座，其中所述测试盒底座构造成接纳所述储存卡，并且其中所述测试盒底座还包括具有中心轴线的反应室，其中所述反应室具有旋转的半椭圆形状; 以及连接到所述反应室的入口通道，其中所述入口通道以所述水平面上方15-60度的角度位于所述反应室上方，并且其中所述入口通道偏离所述反应室的中心轴线。

公开(公告)号：US20150198594A1

公开(公告)日：2015-07-16

申请号：US14670007

申请日：2015-03-26

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： Marvin R. WILLIAMS ,  Charles MCBRAIRTY ,  Daniel W. PFAUTZ ,  Thomas J. ZUPANCIC ,  Lingchun ZENG ,  Andrew WEIMAN ,  Richard S. BRODY ,  Joseph D. KITTLE ,  Anthony TRUSCOTT ,  Robert BARANOWSKI

IPC: G01N33/569

CPC classification number: C12Q1/10 ,  G01N21/75 ,  G01N21/763 ,  G01N33/12 ,  G01N33/56916 ,  G01N2201/0221

Abstract: A test cartridge for use in sample analysis is provided. The test cartridge includes a reservoir card that further includes a reagent that includes living biological cells; and a test cartridge base configured to accept the reservoir card. The reservoir card is configured to interface with a test cartridge base through at least one fluid port. The test cartridge base includes an elliptical reaction chamber having a central axis and an inlet channel connected to the reaction chamber. The inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal and is offset from the central axis of the reaction chamber. Upon introducing a sample to be analyzed into the test cartridge base through the inlet channel, the sample is homogeneously mixed with the reagent while minimizing damage to the living biological cells.

Abstract translation: 提供了用于样品分析的测试盒。 测试盒包括储存卡，其还包括包含活体生物细胞的试剂; 以及被配置为接收储存卡的测试盒底座。 存储卡被配置成通过至少一个流体端口与测试盒基座接口。 测试盒底座包括具有连接到反应室的中心轴线和入口通道的椭圆形反应室。 入口通道以比水平面15-60度的角度位于反应室上方并且偏离反应室的中心轴线。 通过入口通道将要分析的样品引入测试盒底座时，将样品与试剂均匀混合，同时最小化对生物细胞的损伤。

公开(公告)号：US20160327487A1

公开(公告)日：2016-11-10

申请号：US15214175

申请日：2016-07-19

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： Marvin R. WILLIAMS ,  Charles McBRAIRTY ,  Daniel W. PFAUTZ ,  Thomas J. ZUPANCIC ,  Lingchun ZENG ,  Andrew WEIMAN ,  Richard S. BRODY ,  Joseph D. KITTLE ,  Anthony TRUSCOTT ,  Robert BARANOWSKI

IPC: G01N21/76 ,  G01N33/569 ,  B01L3/00 ,  G01N33/02

CPC classification number: G01N21/763 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/047 ,  B01L2300/0816 ,  C12Q1/10 ,  G01N33/02 ,  G01N33/56916 ,  G01N2201/0221

Abstract: A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a contoured reaction chamber; and an inlet channel connected to and entering the reaction chamber at a predetermined angle thereto.

Abstract translation: 一种用于快速样品分析的系统，其包括生物传感器试剂，其中所述生物传感器试剂包括活的生物细胞; 储存卡，其中储存卡存储生物传感器试剂; 和测试盒底座，其中所述测试盒底座被配置为接纳所述储存器卡，并且其中所述测试盒底座还包括成型的反应室; 以及以预定角度连接到反应室并进入反应室的入口通道。

公开(公告)号：US20150197784A1

公开(公告)日：2015-07-16

申请号：US14669970

申请日：2015-03-26

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： Marvin R. WILLIAMS ,  Charles MCBRAIRTY ,  Daniel W. PFAUTZ ,  Thomas J. ZUPANCIC ,  Lingchun ZENG ,  Andrew WEIMAN ,  Richard S. BRODY ,  Joseph D. KITTLE ,  Anthony TRUSCOTT ,  Robert BARANOWSKI

IPC: C12Q1/10

CPC classification number: C12Q1/10 ,  G01N21/75 ,  G01N21/763 ,  G01N33/12 ,  G01N33/56916 ,  G01N2201/0221

Abstract: A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.

Abstract translation: 一种用于快速样品分析的系统，其包括生物传感器试剂，其中所述生物传感器试剂包括活的生物细胞; 储存卡，其中储存卡存储生物传感器试剂; 以及测试盒底座，其中所述测试盒底座构造成接纳所述储存卡，并且其中所述测试盒底座还包括具有中心轴线的反应室，其中所述反应室具有旋转的半椭圆形状; 以及连接到所述反应室的入口通道，其中所述入口通道以所述水平面上方15-60度的角度位于所述反应室上方，并且其中所述入口通道偏离所述反应室的中心轴线。

公开(公告)号：US20130149775A1

公开(公告)日：2013-06-13

申请号：US13711296

申请日：2012-12-11

Applicant: Fundamental Solutions Corporation

Inventor： Marvin R. WILLIAMS ,  Charles MCBRAIRTY ,  Daniel W. PFAUTZ ,  Thomas J. ZUPANCIC ,  Lingchun ZENG ,  Andrew WEIMAN ,  Richard S. BRODY ,  Joseph KITTLE ,  Anthony TRUSCOTT ,  Robert BARANOWSKI

IPC: G01N21/75

CPC classification number: C12Q1/10 ,  G01N21/75 ,  G01N21/763 ,  G01N33/12 ,  G01N33/56916 ,  G01N2201/0221

Abstract: A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample, and emits a detectable signal when the reagent reacts with the sample and detects the presence of the infectious agent. A test cartridge has a reaction chamber for receiving the sample and the reagent. The reaction chamber has a predetermined internal geometry and at least one inner surface. Introducing the sample and the reagent into the test cartridge mixes the sample and the reagent. A testing unit receives the test cartridge, and includes a sensor for detecting an emitted detectable signal. The detection of the emitted detectable signal is indicative of the presence of the infectious agent in the sample.

Abstract translation: 用于实时检测生物样品中感染因子的存在的便携式系统使用检测样品中特定感染因子的存在的试剂，并且当试剂与样品反应并发现存在时发出可检测信号 的感染因子。 测试盒具有用于接收样品和试剂的反应室。 反应室具有预定的内部几何形状和至少一个内表面。 将样品和试剂引入测试盒混合样品和试剂。 测试单元接收测试盒，并且包括用于检测发射的可检测信号的传感器。 发射的可检测信号的检测指示样品中感染因子的存在。