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公开(公告)号:US11859161B2
公开(公告)日:2024-01-02
申请号:US17677517
申请日:2022-02-22
Applicant: Finesse Solutions, Inc.
Inventor: Barbara Paldus , Mark Selker
IPC: C12M1/00 , C12M3/00 , B01L3/00 , C12M1/02 , C12M1/34 , C12M1/06 , C12M3/06 , C12M1/12 , C12M1/26
CPC classification number: C12M23/02 , C12M23/40 , C12M23/44 , C12M23/58 , C12M25/06 , C12M27/00 , C12M27/02 , C12M27/16 , C12M29/10 , C12M29/16 , C12M29/18 , C12M33/14 , C12M41/12 , C12M41/26 , C12M41/44
Abstract: A method of carrying out a bioreaction in a multivessel bioreactor system may include flowing a culture medium at an initial flow rate through one or more fluidic paths between a master vessel and one or more slave vessels, detecting a first culture medium parameter value in the master vessel or the slave vessels, transmitting the first culture medium parameter value to a control system, determining an adjusted flow rate of the culture medium at the control system based on the first culture medium parameter value, and controlling a bidirectional fluid transfer device with the control system to adjust the flow rate of the culture medium through the one or more fluidic paths. The control system may adjust the flow rate of the culture medium to maintain a substantially uniform value of the first culture medium parameter value in the master vessel or the one or more slave vessels.
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公开(公告)号:US20240043783A1
公开(公告)日:2024-02-08
申请号:US18490598
申请日:2023-10-19
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
CPC classification number: C12M41/00 , C12M23/14 , C12M23/28 , C12M27/16 , G01N21/359
Abstract: A method of manufacturing a composite sensor assembly includes: providing a port including a high surface tension thermoplastic, the port having a hollow tubular portion and a base having a polymer surface; fusing the polymer surface of the port to a wall of a polymeric bioprocess vessel so that the port communicates with an opening in the wall; and retaining a sensor unit within the hollow tubular portion of the port with an adhesive, at least a portion of the sensor unit being polymeric, wherein the port provides the sensor unit access to an interior of the polymeric bioprocess vessel.
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公开(公告)号:US11827875B2
公开(公告)日:2023-11-28
申请号:US17370390
申请日:2021-07-08
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
IPC: C12M1/34 , C12M1/00 , C12M3/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/78 , G01N21/80 , G01N21/77
CPC classification number: C12M41/00 , C12M23/14 , C12M23/28 , C12M27/16 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/783 , G01N21/80 , G01N2021/7786
Abstract: A method of manufacturing a composite sensor assembly includes: providing a port including a high surface tension thermoplastic, the port having a hollow tubular portion and a base having a polymer surface; fusing the polymer surface of the port to a wall of a polymeric bioprocess vessel so that the port communicates with an opening in the wall; and retaining a sensor unit within the hollow tubular portion of the port with an adhesive, at least a portion of the sensor unit being polymeric, wherein the port provides the sensor unit access to an interior of the polymeric bioprocess vessel.
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公开(公告)号:US20220169964A1
公开(公告)日:2022-06-02
申请号:US17677517
申请日:2022-02-22
Applicant: Finesse Solutions, Inc.
Inventor: Barbara Paldus , Mark Selker
Abstract: A method of carrying out a bioreaction in a multivessel bioreactor system may include flowing a culture medium at an initial flow rate through one or more fluidic paths between a master vessel and one or more slave vessels, detecting a first culture medium parameter value in the master vessel or the slave vessels, transmitting the first culture medium parameter value to a control system, determining an adjusted flow rate of the culture medium at the control system based on the first culture medium parameter value, and controlling a bidirectional fluid transfer device with the control system to adjust the flow rate of the culture medium through the one or more fluidic paths. The control system may adjust the flow rate of the culture medium to maintain a substantially uniform value of the first culture medium parameter value in the master vessel or the one or more slave vessels.
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公开(公告)号:US11292999B2
公开(公告)日:2022-04-05
申请号:US15427613
申请日:2017-02-08
Applicant: Finesse Solutions, Inc.
Inventor: Barbara Paldus , Mark Selker
Abstract: A bioreactor system may include (a) two or more fluidically coupled vessels configured to collectively carry out a bioreaction; (b) one or more fluidic paths coupling the two or more vessels to one another, where the fluidic paths are configured to provide flow of culture medium between the two or more vessels; (c) one or more fluid transfer devices along at least some of the one or more fluidic paths; and (d) a control system. The control system may be configured to (i) read or receive values of one or more parameters characterizing the culture medium in one or more of the vessels, and (ii) use the values to determine an adjusted flow rate in at least one of the fluidic paths to maintain substantially uniform values of the one or more parameters in the culture medium from vessel-to-vessel among the two or more vessels.
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公开(公告)号:US09346578B2
公开(公告)日:2016-05-24
申请号:US14292637
申请日:2014-05-30
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
CPC classification number: B65B55/02 , A61M39/16 , A61M39/18 , B01L3/508 , B01L2200/06 , B01L2300/06 , B65B5/045 , B65B55/027 , B65B2220/16 , C12M23/00 , C12M23/14 , C12M37/04 , F16L21/02 , G01D21/00 , Y10T29/49828
Abstract: Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel via an aseptic connector affixed to the vessel. The aseptic peripheral connection assembly may include a carrier, an applicator, a plunger, and a removable hermetic sealing tab.
Abstract translation: 本文公开了用于在生物处理容器中安装灭菌的外围设备的装置和方法。 一个方面是一种无菌外围连接组件,用于通过固定在容器上的无菌连接器将生物处理容器中的消毒的外围设备安装。 无菌外围连接组件可以包括载体,施用器,柱塞和可移除的气密密封片。
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公开(公告)号:US20220187128A1
公开(公告)日:2022-06-16
申请号:US17685595
申请日:2022-03-03
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus
Abstract: A method of determining the identity and concentration of a target analyte present in a biological sample includes: introducing a first target analyte into a hollow core of an optical fiber; introducing a first reference calibrant into the hollow core of the optical fiber; transmitting light from a laser light source through the hollow core of the optical fiber and the first target analyte to generate a first Raman anti-Stokes analyte emission corresponding to the first target analyte; receiving the first Raman anti-Stokes analyte emission at a spectral analysis system optically coupled to the optical fiber; and deriving Raman anti-Stokes spectral peaks or spectra of the first target analyte at the spectral analysis system based on the first Raman anti-Stokes analyte emission.
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公开(公告)号:US11060055B2
公开(公告)日:2021-07-13
申请号:US16261977
申请日:2019-01-30
Applicant: FINESSE SOLUTIONS, INC.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
IPC: C12M1/34 , C12M1/00 , G01N21/359 , C12M3/06 , G01N21/552 , G01N21/65 , G01N21/78 , G01N21/80 , G01N21/77
Abstract: A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
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公开(公告)号:US20150345689A1
公开(公告)日:2015-12-03
申请号:US14724659
申请日:2015-05-28
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
CPC classification number: F16L58/185 , A61M39/18 , B01D35/28 , B65B55/08 , B65B55/16 , C12M23/00 , C12M23/14 , C12M23/28 , C12M23/46 , C12M37/04 , F16L21/02 , F16L21/08 , G01D21/00 , Y10T29/49828
Abstract: Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel or component. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel or component via an aseptic connector affixed to the vessel or component. The aseptic peripheral connection assembly may include a carrier, an applicator, and a removable hermetic sealing tab.
Abstract translation: 本文公开了用于将灭菌的外围设备安装在生物处理容器或部件中的装置和方法。 一个方面是一种无菌外围连接组件,用于通过固定在容器或部件上的无菌连接器将消毒的外围物安装在生物处理容器或部件中。 无菌外围连接组件可以包括载体,施用器和可移除的气密密封片。
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公开(公告)号:US20150344161A1
公开(公告)日:2015-12-03
申请号:US14292637
申请日:2014-05-30
Applicant: Finesse Solutions, Inc.
Inventor: Mark Selker , Barbara Paldus , Timothy Johnston
CPC classification number: B65B55/02 , A61M39/16 , A61M39/18 , B01L3/508 , B01L2200/06 , B01L2300/06 , B65B5/045 , B65B55/027 , B65B2220/16 , C12M23/00 , C12M23/14 , C12M37/04 , F16L21/02 , G01D21/00 , Y10T29/49828
Abstract: Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel via an aseptic connector affixed to the vessel. The aseptic peripheral connection assembly may include a carrier, an applicator, a plunger, and a removable hermetic sealing tab.
Abstract translation: 本文公开了用于在生物处理容器中安装灭菌的外围设备的装置和方法。 一个方面是一种无菌外围连接组件,用于通过固定在容器上的无菌连接器将生物处理容器中的消毒的外围设备安装。 无菌外围连接组件可以包括载体,施用器,柱塞和可移除的气密密封片。
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