公开(公告)号：US10006851B2

公开(公告)日：2018-06-26

申请号：US12321123

申请日：2009-01-15

Applicant: Fraser McNeil-Watson ,  Malcolm Connah ,  Robert Jack ,  David McKnight

Inventor： Fraser McNeil-Watson ,  Malcolm Connah ,  Robert Jack ,  David McKnight

IPC: G01N21/00 ,  G01N15/14 ,  G01N15/00

CPC classification number: G01N15/1429 ,  G01N15/1427 ,  G01N2015/0065 ,  G01N2015/0096

Abstract: Methods and apparatus for measuring particle characteristics are disclosed. In one aspect, an amount of light arising from interaction between light and a suspended sample is detected simultaneously with the acquisition of a photon count from a different direction. At least one measure of particle characteristics can then be derived based at least in part on timing between information from the steps of acquiring and detecting.

公开(公告)号：US08634076B2

公开(公告)日：2014-01-21

申请号：US12857878

申请日：2010-08-17

Applicant: Fraser McNeil-Watson

Inventor： Fraser McNeil-Watson

IPC: G01N21/00

CPC classification number: G01N21/51

Abstract: In one general aspect, a multi-sample liquid scattering measurement apparatus is disclosed. It includes a coherent light source having an optical output axis, with sample cells that each include a volume that intersects with the optical output axis. Detectors are each positioned to detect scattered light resulting from an interaction between light from the coherent light source and one of the cells. Light scattering analysis logic is responsive to the detectors and operative to determine a property of a liquid sample in each of the sample cells based on the detected scattered light.

Abstract translation: 在一般的方面，公开了一种多样品液体散射测量装置。 它包括具有光输出轴的相干光源，每个样本单元包括与光输出轴相交的体积。 检测器各自被定位成检测由相干光源和其中一个单元之间的相互作用产生的散射光。 光散射分析逻辑响应于检测器并且可操作以基于检测到的散射光来确定每个样品池中的液体样品的性质。

公开(公告)号：US20110157586A1

公开(公告)日：2011-06-30

申请号：US12857878

申请日：2010-08-17

Applicant: Fraser McNeil-Watson

Inventor： Fraser McNeil-Watson

IPC: G01N21/47

CPC classification number: G01N21/51

Abstract: In one general aspect, a multi-sample liquid scattering measurement apparatus is disclosed. It includes a coherent light source having an optical output axis, with sample cells that each include a volume that intersects with the optical output axis. Detectors are each positioned to detect scattered light resulting from an interaction between light from the coherent light source and one of the cells. Light scattering analysis logic is responsive to the detectors and operative to determine a property of a liquid sample in each of the sample cells based on the detected scattered light.

Abstract translation: 在一般的方面，公开了一种多样品液体散射测量装置。 它包括具有光输出轴的相干光源，每个样本单元包括与光输出轴相交的体积。 检测器各自被定位成检测由相干光源和其中一个单元之间的相互作用产生的散射光。 光散射分析逻辑响应于检测器并且可操作以基于检测到的散射光来确定每个样品池中的液体样品的性质。

公开(公告)号：US20110155650A1

公开(公告)日：2011-06-30

申请号：US12972318

申请日：2010-12-17

Applicant: Fraser McNeil-Watson

Inventor： Fraser McNeil-Watson

IPC: B03B5/00 ,  G01N21/49

CPC classification number: G01N30/0005 ,  G01N15/1459 ,  G01N27/44721 ,  G01N2015/1493 ,  G01N2030/0025

Abstract: In one general aspect, an instrument for measuring characteristics of particles suspended in a fluid is disclosed. It includes a closed wall surface defining a fractionation channel having a input opening, an output opening, and a flow axis that spans downstream from the input opening for the channel to the output opening. A force application subsystem has a force application output oriented perpendicular to at least part of the flow axis of the fractionation channel. A particle characteristic measurement subsystem is located hydraulically downstream from at least a portion of the closed wall surface defining the fractionation channel, and includes a sensor positioned to sense a property of the suspended particles in the potential measurement subsystem as well as a signal output responsive to the sensor. A result processor has a signal input responsive to the signal output of the particle characteristic measurement subsystem, zeta potential processing logic responsive to the particle characteristic measurement subsystem, and a particle characteristic signal output responsive to the particle characteristic processing logic.

Abstract translation: 在一般的方面，公开了一种用于测量悬浮在流体中的颗粒的特性的仪器。 它包括封闭的壁表面，其限定了具有输入开口的分馏通道，输出开口和流动轴线，该流动轴线从用于通道的输入开口的下游跨越到输出开口。 力应用子系统具有垂直于分馏通道的流动轴的至少一部分定向的力施加输出。 颗粒特征测量子系统位于限定分馏通道的封闭壁表面的至少一部分的液压下游，并且包括定位成感测潜在测量子系统中的悬浮颗粒的性质的传感器以及响应于 传感器。 结果处理器具有响应于粒子特性测量子系统的信号输出的信号输入，响应于粒子特性测量子系统的ζ电位处理逻辑，以及响应于粒子特征处理逻辑的粒子特征信号输出。

公开(公告)号：US08573404B2

公开(公告)日：2013-11-05

申请号：US12972318

申请日：2010-12-17

Applicant: Fraser McNeil-Watson

Inventor： Fraser McNeil-Watson

IPC: B03B5/00

CPC classification number: G01N30/0005 ,  G01N15/1459 ,  G01N27/44721 ,  G01N2015/1493 ,  G01N2030/0025

Abstract: In one general aspect, an instrument for measuring characteristics of particles suspended in a fluid is disclosed. It includes a closed wall surface defining a fractionation channel having a input opening, an output opening, and a flow axis that spans downstream from the input opening for the channel to the output opening. A force application subsystem has a force application output oriented perpendicular to at least part of the flow axis of the fractionation channel. A particle characteristic measurement subsystem is located hydraulically downstream from at least a portion of the closed wall surface defining the fractionation channel, and includes a sensor positioned to sense a property of the suspended particles in the potential measurement subsystem as well as a signal output responsive to the sensor. A result processor has a signal input responsive to the signal output of the particle characteristic measurement subsystem, zeta potential processing logic responsive to the particle characteristic measurement subsystem, and a particle characteristic signal output responsive to the particle characteristic processing logic.

Abstract translation: 在一般的方面，公开了一种用于测量悬浮在流体中的颗粒的特性的仪器。 它包括封闭的壁表面，其限定了具有输入开口的分馏通道，输出开口和流动轴线，该流动轴线从用于通道的输入开口的下游跨越到输出开口。 力应用子系统具有垂直于分馏通道的流动轴的至少一部分定向的力施加输出。 颗粒特征测量子系统位于限定分馏通道的封闭壁表面的至少一部分的液压下游，并且包括定位成感测潜在测量子系统中的悬浮颗粒的性质的传感器以及响应于 传感器。 结果处理器具有响应于粒子特性测量子系统的信号输出的信号输入，响应于粒子特性测量子系统的ζ电位处理逻辑，以及响应于粒子特征处理逻辑的粒子特征信号输出。

公开(公告)号：US20090251696A1

公开(公告)日：2009-10-08

申请号：US12321123

申请日：2009-01-15

Applicant: Fraser McNeil-Watson ,  Malcolm Connah ,  Robert Jack ,  David McKnight

Inventor： Fraser McNeil-Watson ,  Malcolm Connah ,  Robert Jack ,  David McKnight

IPC: G01N15/02

CPC classification number: G01N15/1429 ,  G01N15/1427 ,  G01N2015/0065 ,  G01N2015/0096

Abstract: Methods and apparatus for measuring particle characteristics are disclosed. In one aspect, an amount of light arising from interaction between light and a suspended sample is detected simultaneously with the acquisition of a photon count from a different direction. At least one measure of particle characteristics can then be derived based at least in part on timing between information from the steps of acquiring and detecting.

Abstract translation: 公开了用于测量颗粒特性的方法和装置。 在一个方面，与从不同方向获取光子计数同时检测由光和悬浮样品之间的相互作用产生的光量。 至少部分地基于来自获取和检测步骤的信息之间的定时导出至少一个粒子特性测量。

公开(公告)号：US09829525B2

公开(公告)日：2017-11-28

申请号：US14126673

申请日：2012-06-13

Applicant: Jason Corbett ,  Fraser McNeil-Watson ,  Robert Jack

Inventor： Jason Corbett ,  Fraser McNeil-Watson ,  Robert Jack

IPC: G01N27/416 ,  G01N27/42 ,  G01R29/24 ,  G01N21/51

CPC classification number: G01R29/24 ,  G01N15/00 ,  G01N21/51 ,  G01N27/447 ,  G01N2021/513

Abstract: The invention relates to methods and apparatus for determining properties of a surface. Embodiments disclosed include an apparatus for measuring a surface charge of a sample, comprising: a sample holder having an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the electrodes such that a planar surface of the sample is aligned orthogonal to the electrode surfaces; a measurement chamber for containing a measurement liquid and having an open end configured to receive the sample holder to position the electrodes in a preset orientation; a laser light source positioned and configured to direct a laser beam through the measurement chamber between the electrodes and parallel to the planar surface of the sample when the sample holder is received in the measurement chamber; and a detector positioned and configured to detect scattered light from the measurement volume, wherein the apparatus is configured to allow for detection of the scattered light by the detector over a range of distances from the surface of the sample.

公开(公告)号：US09341564B2

公开(公告)日：2016-05-17

申请号：US13123518

申请日：2009-10-09

Applicant: Fraser McNeil-Watson

Inventor： Fraser McNeil-Watson

IPC: G01N27/453 ,  G01N21/25 ,  B01L3/00 ,  G01N21/51 ,  G01N27/447 ,  G01N21/03 ,  G01N15/14 ,  G01N21/47

CPC classification number: G01N21/253 ,  B01L3/5025 ,  B01L2300/0829 ,  B01L2400/0421 ,  G01N21/03 ,  G01N21/51 ,  G01N27/44721 ,  G01N2015/1493 ,  G01N2021/0346 ,  G01N2021/4707 ,  G01N2021/513 ,  G01N2201/103 ,  G01N2201/105

Abstract: A high-throughput optical suspension characterization instrument is disclosed, which can include hydraulically separate and at least partially transparent sample containers. A selection mechanism is operative to selectively direct light from a light source (12) through different ones of the sample containers along an optical axis, and an off-axis scattering detector (38,24) is responsive to scattered light from the light source after it has interacted with a sample. Phase analysis light scattering is used to determine the electrophoretic mobility and zeta potential of samples. A second instrument is disclosed, wherein all sample containers are illuminated simultaneously. Transmitted light is collected by a camera. The electrophoretic mobility and hydrodynamic size of the samples may be determined.

Abstract translation: 公开了一种高通量光学悬浮表征仪器，其可以包括液压分离和至少部分透明的样品容器。 选择机构可操作以沿着光轴选择性地将来自光源（12）的光引导通过不同的样本容器，并且离轴散射检测器（38,24）响应于来自光源的散射光， 它已经与样本进行了互动。 相位分析光散射用于确定样品的电泳迁移率和ζ电位。 公开了第二种仪器，其中所有的样品容器都是同时照射的。 透射光被照相机收集。 可以确定样品的电泳迁移率和流体动力学尺寸。

公开(公告)号：US20150022212A1

公开(公告)日：2015-01-22

申请号：US14126673

申请日：2012-06-13

Applicant: Corbett Jason ,  Fraser McNeil-Watson ,  Jack Robert

Inventor： Corbett Jason ,  Fraser McNeil-Watson ,  Jack Robert

IPC: G01R29/24 ,  G01N21/47

CPC classification number: G01R29/24 ,  G01N15/00 ,  G01N21/51 ,  G01N27/447 ,  G01N2021/513

Abstract: The invention relates to methods and apparatus for determining properties of a surface. Embodiments disclosed include an apparatus for measuring a surface charge of a sample, comprising: a sample holder having an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the electrodes such that a planar surface of the sample is aligned orthogonal to the electrode surfaces; a measurement chamber for containing a measurement liquid and having an open end configured to receive the sample holder to position the electrodes in a preset orientation; a laser light source positioned and configured to direct a laser beam through the measurement chamber between the electrodes and parallel to the planar surface of the sample when the sample holder is received in the measurement chamber; and a detector positioned and configured to detect scattered light from the measurement volume, wherein the apparatus is configured to allow for detection of the scattered light by the detector over a range of distances from the surface of the sample.

Abstract translation: 本发明涉及用于确定表面特性的方法和装置。 所公开的实施例包括用于测量样品的表面电荷的装置，包括：样品保持器，其具有相对的一对电极并且被配置为将样品保持在电极之间的测量体积中的适当位置，使得样品的平坦表面对准 与电极表面正交; 测量室，用于容纳测量液体，并且具有构造成接收样品架以将电极定位在预定方位的开口端; 激光光源，被定位和配置为当样品保持器被容纳在测量室中时，将激光束引导通过电极之间的测量室并平行于样品的平面; 以及检测器，其被定位和配置为检测来自测量体积的散射光，其中所述装置被配置为允许在距所述样品表面的距离范围内由所述检测器检测散射光。