公开(公告)号：US20240082834A1

公开(公告)日：2024-03-14

申请号：US17767991

申请日：2020-07-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kazumasa HIRAWAKE ,  Takahiro MURAKOSHI ,  Takahiro SHIKAYAMA ,  Takayuki SATO

IPC: B01L3/00

CPC classification number: B01L3/50 ,  B01L2300/0609

Abstract: A biological sample holding container includes: a container main body having a bottom surface portion having a placement region for a biological sample and a side surface portion provided on the bottom surface portion so as to surround the placement region; and an annular holding member insertable and removable inside the side surface portion. The holding member holds a film covering the biological sample on the placement region with the bottom surface portion by being inserted inside the side surface portion together with the film.

公开(公告)号：US20220170858A1

公开(公告)日：2022-06-02

申请号：US17441402

申请日：2019-12-02

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kazumasa HIRAWAKE ,  Takahiro MURAKOSHI ,  Takahiro SHIKAYAMA ,  Takayuki SATO

IPC: G01N21/64

Abstract: A fluorescence observation device is a device for performing fluorescence observation of a sample piece cut out from a sample including: a tray on which the sample piece is placed; a light source unit which generates excitation light to irradiate the sample piece; a detection unit which detects fluorescence from the sample piece; and an image generation unit which generates a fluorescence image of the sample piece based on a detection signal from the detection unit and the tray includes a plurality of placement regions provided around a center region of the tray and also includes a marker portion indicating a cutting orientation of the sample piece with respect to the sample.

公开(公告)号：US20180082411A1

公开(公告)日：2018-03-22

申请号：US15557873

申请日：2016-02-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takayuki SATO ,  Mitsuharu MIWA ,  Kazumasa HIRAWAKE

IPC: G06T5/50 ,  A61B1/04

CPC classification number: G06T5/50 ,  A61B1/00009 ,  A61B1/043 ,  G01N21/6456 ,  G02B21/0076 ,  G06T2207/10064 ,  G06T2207/10152 ,  G06T2207/20221 ,  H04N5/2256

Abstract: A fluorescent image acquisition system includes a light emitting device which emits excitation light during ON period and stop the emission of the excitation light during OFF period, an imaging device which outputs ON image data and OFF image data, an input device which sets a coefficient, an image processing unit which creates fluorescent image data and background image data, and an identification unit which identifies fluorescent pixels and non-fluorescent pixels. In order to create a superimposed image, the image processing unit calculates values obtained by summing pixel values of fluorescent pixels of the fluorescent image data and pixel values of fluorescent pixels of the background image data at a ratio of 1:1, as pixel values of the fluorescent pixels and calculates values obtained by multiplying at least pixel values of the non-fluorescent pixels of the background image by the coefficient, as pixel values of the non-fluorescent pixels.

公开(公告)号：US20160156820A1

公开(公告)日：2016-06-02

申请号：US14903474

申请日：2013-07-12

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takayuki SATO

IPC: H04N5/225 ,  H04N5/33

CPC classification number: H04N5/2256 ,  F21K9/65 ,  F21Y2107/10 ,  G01N21/01 ,  G01N21/645 ,  G01N21/6456 ,  G03B15/02 ,  G03B15/05 ,  H04N5/2253 ,  H04N5/33

Abstract: In an imaging device, a tilted surface is formed on one surface side of a base, while a flexible substrate arranged with light sources is secured along the tilted surface of the base, so as to adjust the optical axis of an imaging unit and positions illuminated by the light sources. Thus, the respective optical axes of light sources are regulated not individually but at once by placing the substrate along the tilted surface, which makes it easy to adjust the illumination positions. It is also excellent in heat dissipation of the light sources, since the heat generated by the light sources dissipates through the base. This enables the light sources to keep their output stability favorably.

Abstract translation: 在成像装置中，在基部的一个表面侧上形成有倾斜面，同时沿着基部的倾斜面固定设置有光源的柔性基板，以调整成像单元的光轴并且位置被照亮 由光源。 因此，光源的各个光轴不是单独地调节，而是通过沿着倾斜面放置基板，这使得容易调节照明位置。 由于光源产生的热量通过基底消散，所以光源的散热也优异。 这使得光源能够有利地保持其输出稳定性。