公开(公告)号：US20220082504A1

公开(公告)日：2022-03-17

申请号：US17415203

申请日：2019-06-04

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Steven Barcelo ,  Anita Rogacs

IPC: G01N21/65 ,  G01N21/27

Abstract: Systems and methods for generating calibration curve for a sensor are provided. An example method includes printing at least two spots of an analyte on the sensor, wherein each of the spots includes a different number of overprinted droplets ejected from a single printhead.

公开(公告)号：US10712278B2

公开(公告)日：2020-07-14

申请号：US15569764

申请日：2015-06-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Charles M. Santori ,  Ning Ge ,  Zhiyong Li ,  Steven Barcelo

IPC: G01N21/03 ,  G01N21/65 ,  G01N21/11

Abstract: Provided in one example is an analyte detection package that includes a chamber, a surface-enhanced luminescence analyte stage within the chamber, and a lens integrated as part of the package to focus radiation onto the analyte stage.

公开(公告)号：US20180284027A1

公开(公告)日：2018-10-04

申请号：US15764324

申请日：2015-11-13

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning GE ,  Steven Barcelo ,  Charles M Santori ,  Helen A Holder

IPC: G01N21/65 ,  G01N21/03

CPC classification number: G01N21/658 ,  G01N21/03

Abstract: In an example implementation, a substance detection device includes a substrate having nanoimprinted chamber walls and nanostructures. The chamber walls define a chamber and the nanostructures are positioned within the chamber to react to a substance introduced into the chamber. A two-dimensional (2D) orifice plate is affixed to the chamber walls and forms a top side of the chamber.

公开(公告)号：US20150211998A1

公开(公告)日：2015-07-30

申请号：US14414206

申请日：2012-10-31

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Huei Pei Kuo ,  Zhiyong Li ,  Shih-Yuan Wang ,  Alexandre M. Bratkovski ,  Steven Barcelo ,  Ansoon Kim ,  Gary Gibson ,  Mineo Yamakawa

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/65 ,  G01N21/64 ,  G01N2201/06113

Abstract: A system includes an illumination source, a detector and a processor. The detector acquires spectral measurements of a sample under test under at least one varying condition. The processor processes the measurements to generate at least one spectral representation that includes Raman spectra and at least one spectral representation that includes non-Raman spectra.

Abstract translation: 系统包括照明源，检测器和处理器。 检测器在至少一个变化的条件下获得被测样品的光谱测量。 处理器处理测量以产生包括拉曼光谱和包括非拉曼光谱的至少一个光谱表示的至少一个光谱表示。

公开(公告)号：US11118974B2

公开(公告)日：2021-09-14

申请号：US16611968

申请日：2017-07-19

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs

IPC: G01J3/44 ,  G01N21/64 ,  G01N21/65

Abstract: A spectroscopic device is provided. The spectroscopic device includes a plurality of design groups on a substrate. Each design group includes a plurality of collapsed groups separated by bare regions of substrate, wherein the edges of each design group is configured to enhance the pinning of a solvent drying line at the edge of the design group. Each collapsed group comprises at least 2 flexible columnar structures, and each flexible columnar structure comprises a metal cap.

公开(公告)号：US20210214663A1

公开(公告)日：2021-07-15

申请号：US17047349

申请日：2018-08-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Fausto D'Apuzzo ,  Caitlin DeJong ,  Milo Overbay

IPC: C12M1/32 ,  C12M1/26 ,  G01N21/3577 ,  C12Q1/18 ,  C12M3/06

Abstract: An example of an apparatus includes a plurality of wells, wherein each well is to receive a cell culture and a cell culture liquid. The apparatus also includes a collector to contact the cell culture liquid in a well selected from the plurality of wells. The collector is to draw a microfluidic sample of the cell culture liquid from the well. In addition, the apparatus includes a sensor substrate to receive the microfluidic sample, wherein the sensor substrate is to be used to measure a characteristic of the cell culture liquid. Also, the apparatus includes a microfluidic channel to transport the microfluidic sample from the collector to the sensor substrate.

公开(公告)号：US20210096079A1

公开(公告)日：2021-04-01

申请号：US16968330

申请日：2018-04-06

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44

Abstract: A luminescence-enhancement system can include a luminescence-enhancement sensor having a substrate and a group of nanofingers with individual nanofingers that can be flexible and include a support end attached to the substrate, a distal tip positioned distally with respect to the substrate, and a middle portion between the support end and the distal tip. A coating of a metal or metal alloy can be applied to the substrate and the distal tip that is conductively continuous. The middle portion can be devoid of the coating or the coating at the middle portion is conductively discontinuous. A liquid ejector can be present and can include a jetting nozzle to eject a liquid droplet having a volume of 2 pL to 10 μL. The group of nanofingers and the jetting nozzle can be positionable relative to one another for the droplet to be deposited on the group of nanofingers.

公开(公告)号：US10935494B2

公开(公告)日：2021-03-02

申请号：US15940937

申请日：2018-03-29

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs

IPC: G01N21/65 ,  G01N33/543 ,  G01N21/64

Abstract: A surface enhanced luminescence (SEL) sensing stage may include a matrix and plasmonically active nanostructures retained within the matrix, wherein no greater than 10% of the plasmonically active nanostructures consist of a single unagglomerated plasmonically active nano particle.

公开(公告)号：US20180284028A1

公开(公告)日：2018-10-04

申请号：US15764327

申请日：2015-11-30

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Ning Ge ,  Steven Barcelo ,  Anita Rogacs ,  Helen A Holder

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44 ,  B65B31/06

Abstract: In an example implementation, a substance detection device includes a chamber with chamber walls, a chamber top, and a chamber bottom. A substrate comprises imprinted nanostructures positioned within the chamber, and the substrate is coupled to the chamber walls to form the chamber bottom. An inert gas is sealed within the chamber.

公开(公告)号：US20180136135A1

公开(公告)日：2018-05-17

申请号：US15569767

申请日：2015-07-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Ning Ge ,  Zhiyong Li

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: In one example, a structure for surface enhanced Raman spectroscopy includes a cluster of metal nanoparticles in a hole.