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    APPLICATOR
    2.
    发明申请
    APPLICATOR 审中-公开

    公开(公告)号：US20190388668A1

    公开(公告)日：2019-12-26

    申请号：US16471290

    申请日：2017-12-15

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Seiji TOKUMOTO

    IPC: A61M37/00

    Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.

    Applicator
    3.
    发明申请
    Applicator 审中-公开

    公开(公告)号：US20190083770A1

    公开(公告)日：2019-03-21

    申请号：US15756234

    申请日：2016-08-19

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Masafumi ONO

    IPC: A61M37/00

    Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

    Bag for Liquids
    5.
    发明申请
    Bag for Liquids 审中-公开

    公开(公告)号：US20190117512A1

    公开(公告)日：2019-04-25

    申请号：US16061866

    申请日：2016-12-01

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Yusuke SHIROTANI ,  Kazuki KURIYAMA ,  Seiji TOKUMOTO

    IPC: A61J1/14 ,  A61J1/10 ,  A61M5/165 ,  A61M5/168 ,  A61M5/158

    Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.

    Applicator
    6.
    发明申请
    Applicator 审中-公开
    申请人

    公开(公告)号：US20160263363A1

    公开(公告)日：2016-09-15

    申请号：US15032709

    申请日：2014-11-04

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke ARAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

    Abstract translation: 施用器被构造成通过皮肤用皮肤穿刺用微针将活性成分转移到皮肤中。 涂抹器包括活塞板，活塞板在活塞板的主体的下表面侧设置有第一突出部和第二突出部。 微针设置在第一突出部的表面上。 第二突起部分设置在与第一突出部分间隔开的第一突出部分的周边。

    Applicator, Cartridge and Application Kit
    7.
    发明申请
    Applicator, Cartridge and Application Kit 审中-公开

    公开(公告)号：US20200316355A1

    公开(公告)日：2020-10-08

    申请号：US16767290

    申请日：2018-11-06

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Takuya TAJIMA ,  Naoki YAMAMOTO ,  Seiji TOKUMOTO

    IPC: A61M37/00

    Abstract: An application kit according to one embodiment includes: a cartridge including a sheet member; and an applicator being connectable to the cartridge. The cartridge includes a bending portion configured to bend the sheet member and a cartridge-side connector configured to be detachably connected to the applicator. The applicator includes: an applicator body; an applicator-side connector provided to a bottom portion of the applicator body; a cap provided above the applicator body and being movable along a height direction of the applicator body; and an elastic member extending along the height direction between the applicator body and the cap and configured to apply, to the cap, an elastic force that acts in a direction away from the bottom portion.

    APPLICATOR
    9.
    发明申请
    APPLICATOR 有权
    申请人

    公开(公告)号：US20150314117A1

    公开(公告)日：2015-11-05

    申请号：US14654029

    申请日：2013-11-27

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Shunsuke ARAMI ,  Makoto OGURA ,  Seiji TOKUMOTO

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M5/1454 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0046

    Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

    Abstract translation: 施加器包括活塞板，非线性螺旋弹簧，壳体，锁定装置和释放装置。 壳体包括容纳活塞板和非线性螺旋弹簧的管状主体部分和布置在主体部分的一端侧的盖部分。 盖部分和活塞板夹在其间的非线性螺旋弹簧。 锁定装置将活塞板与壳体锁定，使得活塞板在盖部分和活塞板压缩非线性螺旋弹簧的状态下在盖部分侧保持在其缩回位置。 释放装置释放锁定状态，其中活塞板通过锁定装置与壳体锁定，并且盖部分和活塞板压缩非线性螺旋弹簧。

    METHOD FOR PRODUCING MICRONEEDLE DEVICE
    10.
    发明申请
    METHOD FOR PRODUCING MICRONEEDLE DEVICE 审中-公开

    公开(公告)号：US20190381300A1

    公开(公告)日：2019-12-19

    申请号：US16488450

    申请日：2018-02-20

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Toru KOBAYASHI ,  Toshiyuki MATSUDO ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Tetsuji KUWAHARA

    IPC: A61M37/00

    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

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