公开(公告)号：US20160334428A1

公开(公告)日：2016-11-17

申请号：US15111195

申请日：2015-01-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kenta IMAI ,  Yoshinori NEGISHI ,  Toshinari SAKURAI ,  Kyoko IMAI

IPC: G01N35/00 ,  G01N27/416 ,  G01N27/49 ,  G01N35/10

CPC classification number: G01N35/0098 ,  G01N27/4163 ,  G01N27/49 ,  G01N35/1095

Abstract: When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.

Abstract translation: 当使用电化学方法在水溶液中生物来源的样品用作测量介质时，施加+1.2V或更大的电压（以饱和银 - 氯化银电极电位为参考），则存在 由于来自测量缓冲液的电解反应，观察到在流动池内产生气泡的情况。 存在在电极上产生的气泡将覆盖电极表面的可能性，减小了电极的有效表面积。 此外，捕获在电极上的磁性颗粒的分布将受到由此产生的气体的干扰，降低了分析结果的再现性。 在将测量介质引入检测器之前，测量介质的脱气最大限度地降低了气泡产生在降解分析能力方面的影响，使得可以进行高灵敏度的电化学分析。