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公开(公告)号:US20180224474A1
公开(公告)日:2018-08-09
申请号:US15750526
申请日:2016-07-25
Applicant: Hitachi High-Technologies Corporation
Inventor: Shunsuke SASAKI , Kenta IMAI , Toshiharu SUZUKI , Katsuhiko SAKAMOTO
IPC: G01N35/00
CPC classification number: G01N35/00584 , G01N35/00 , G01N2035/00346
Abstract: The purpose of the present invention is to attain an automated analyzer that keeps the costs required for inspection to a minimum and is capable of starting measurement immediately after being turned on. As a solution, provided is an automated analyzer provided with an analysis operation part that causes a sample and a reagent to react and on the basis of the reaction result performs analysis of the sample, wherein: the automated analyzer comprises a plurality of units constituting the analysis operation part, a temperature adjustment mechanism that heats or cools the units, a temperature sensor that measures the temperature of the units, and a control part that controls the temperature adjustment mechanism; and the control part sets the measurement startable temperature range of each unit, which is the temperature range of the operation specification thereof, and the operable temperature range, which is a temperature range that is wider than the measurement startable temperature range, and starts the analysis process of the sample when the temperature of the unit has entered the operable temperature range of the unit.
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公开(公告)号:US20190351419A1
公开(公告)日:2019-11-21
申请号:US16477535
申请日:2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor: Hiroki FUJITA , Toshiharu SUZUKI , Takenori OKUSA , Shunsuke SASAKI , Yoshihiro YAMASHITA , Kenta IMAI
Abstract: The mixing of reagents with each other in the reagent storage flow paths of an automatic analyzer is suppressed before and after exchange of the reagents, which are capable of being replenished without stopping analysis. An exchangeable reagent container that accommodates a reagent is connected to a reagent storage flow path that stores a portion of the reagent. The reagent storage flow path has first and second flow paths in which the second flow path is branched from the first flow path. A reagent syringe applies a negative or a positive pressure to the first and second flow paths; and a valve controls the flow path through which the reagent is sent. As a result, the reagent supplied to a measurement portion at a predetermined timing is switched from the reagent container to the reagent storage flow path wherein the reagent can be supplied without stopping analysis.
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公开(公告)号:US20180188181A1
公开(公告)日:2018-07-05
申请号:US15736797
申请日:2016-07-13
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor: Shunichiro NOBUKI , Muneo MAESHIMA , Kenta IMAI
CPC classification number: G01N21/76 , G01N21/0303 , G01N21/253 , G01N35/1002 , G01N2201/08 , G02B6/0096 , G02B6/4298
Abstract: A highly reflective light-guide system has a highly reflective light-guide surface for reflecting light that has been emitted from a sample and has entered from an entry port opposing a window material and propagating the same to an exit port opposing a light reception surface of a photodetector. An optical filter is provided in a space surrounded by the window material, the photodetector, and the highly reflective light-guide system and transmits the signal luminescence to be measured that is emitted from the sample between the window material and photodetector. The optical filter is fixed to the window material or photodetector by an adhesive, and the peripheral shape of the optical filter is smaller than the shape of the inside of a fitting part to which the optical filter is fitted and that is formed on the highly reflective light-guide system.
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公开(公告)号:US20160334428A1
公开(公告)日:2016-11-17
申请号:US15111195
申请日:2015-01-09
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor: Kenta IMAI , Yoshinori NEGISHI , Toshinari SAKURAI , Kyoko IMAI
IPC: G01N35/00 , G01N27/416 , G01N27/49 , G01N35/10
CPC classification number: G01N35/0098 , G01N27/4163 , G01N27/49 , G01N35/1095
Abstract: When a sample of biological origin in an aqueous solution is used as the measurement medium in analysis using an electrochemical process, and a voltage of +1.2 V or greater (with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. Also, the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. Deaeration of the measurement medium prior to introduction of the measurement medium into the detector minimizes the effects of bubble production in degrading the analytical capability makes it possible to carry out highly sensitive electrochemical analysis.
Abstract translation: 当使用电化学方法在水溶液中生物来源的样品用作测量介质时,施加+1.2V或更大的电压(以饱和银 - 氯化银电极电位为参考),则存在 由于来自测量缓冲液的电解反应,观察到在流动池内产生气泡的情况。 存在在电极上产生的气泡将覆盖电极表面的可能性,减小了电极的有效表面积。 此外,捕获在电极上的磁性颗粒的分布将受到由此产生的气体的干扰,降低了分析结果的再现性。 在将测量介质引入检测器之前,测量介质的脱气最大限度地降低了气泡产生在降解分析能力方面的影响,使得可以进行高灵敏度的电化学分析。
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公开(公告)号:US20180246133A1
公开(公告)日:2018-08-30
申请号:US15756431
申请日:2016-07-01
Inventor: Kenta IMAI , Toshiharu SUZUKI , Shigeki MATSUBARA , Takayuki SUGIME , Shunsuke SASAKI , Elke FAATZ , Beatus OFENLOCH-HAEHNLE
CPC classification number: G01N35/1002 , G01N35/00663 , G01N35/00693 , G01N35/1011 , G01N2035/00673
Abstract: In conventional automatic analyzers, there have been instances where, when a plurality of associated items are analyzed as a set item, there is high variation in the analysis data obtained using the set item, leading to a need for improvement of analysis precision. The present invention comprises performing, in mutual association, a set of preparation steps to carry out until it is time to analyze an unknown sample, the set of preparation steps including a pre-preparation step in which stirring, etc., is performed when an analysis reagent kit is mounted on the analyzer, and a step for correcting a standard curve in which correction samples that correspond to analysis items are used. This makes it possible to perform analysis after the preparation states of a plurality of analysis reagent kits are collected as needed, enabling high-precision analysis of a set item.
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公开(公告)号:US20180011121A1
公开(公告)日:2018-01-11
申请号:US15550095
申请日:2016-01-07
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor: Reika KURODA , Kenta IMAI , Yukinori SAKASHITA , Yoshihiro YAMASHITA
Abstract: Provided are an automated analyzer for analyzing a substance contained in an unknown sample and a liquid reservoir, the analyzer and the reservoir being capable of saving users' operation without remarkably increasing the number of components. A flow path outlet of an overflow portion of the liquid reservoirs projects closer to the inner circumferential side of a drain flow path than to an inner circumferential surface side of an outer wall of the drain flow path serving as a destination to which liquid overflows. In addition, the flow path outlet projects so as to come into contact with an outer wall of the inner pipe. The flow path outlet of the overflow portion projects into the drain flow path so as to be located below an upper end of the outer wall of the drain flow path.
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公开(公告)号:US20200278367A1
公开(公告)日:2020-09-03
申请号:US16647109
申请日:2018-11-15
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor: Kenta IMAI , Shunsuke SASAKI , Hiroya UMEKI , Tatsuki TAKAKURA , Takenori OKUSA , Hiroki FUJITA , Taku SAKAZUME
Abstract: To provide an automated analyzer capable of shortening analysis time. The automated analyzer includes a vessel which contains a mixed solution of a specimen and a reagent; and a control unit which controls a first operation performed on the vessel, a second operation performed on the vessel after the first operation, and a third operation performed on a predetermined mechanism of the automated analyzer before the second operation, in which the control unit performs the first operation and the third operation in parallel. Alternatively, the automated analyzer includes a control unit which controls a first operation performed on the vessel, a second operation performed on the vessel after the first operation, and a third operation performed on a predetermined mechanism of the automated analyzer after the first operation, in which the control unit performs the second operation and the third operation in parallel.
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公开(公告)号:US20160077035A1
公开(公告)日:2016-03-17
申请号:US14955776
申请日:2015-12-01
Applicant: Hitachi High-Technologies Corporation
Inventor: Hiroshi KANEMOTO , Hauro AKAHOSHI , So OGUCHI , Kenta IMAI , Taku SAKAZUME , Hiroshi YOSHIDA
IPC: G01N27/30 , G01N27/403
CPC classification number: G01N27/307 , C25B11/0426 , C25B11/0431 , C25B11/0473 , C25B11/0484 , C25F3/16 , C25F7/00 , G01N27/30 , G01N27/3271 , G01N27/403 , G01N33/4915 , H01M4/92 , H01M4/921 , H01M4/923 , H01M4/925
Abstract: Provided are an electrode, an electrolysis cell, and an electrochemical analyzer that improve the long-term stability of analysis data. A working electrode, a counter electrode, and reference electrode are disposed in an electrolysis cell. The working electrode is obtained by forming a lead wire in a composite material having platinum or a platinum alloy as a base material, in which a metal oxide is dispersed, or in a laminated material obtained by laminating a valve metal and platinum such that the cross sectional crystal texture in the thickness direction of the platinum is formed in layers and the thickness of each layer of the platinum is 5 micrometers or less. The metal oxide is selected from among zirconium oxide, tantalum oxide, and niobium oxide, and the metal oxide content of the platinum or the platinum alloy is 0.005 to 1 wt % in terms of the zirconium, tantalum, or niobium metal.
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公开(公告)号:US20200249249A1
公开(公告)日:2020-08-06
申请号:US16477221
申请日:2018-02-15
Applicant: Hitachi High-Technologies Corporation
Inventor: Hiroya UMEKI , Kenta IMAI , Yoshihiro YAMASHITA , Shunsuke SASAKI , Akihiro ENDOU
Abstract: An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
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公开(公告)号:US20200241029A1
公开(公告)日:2020-07-30
申请号:US16641349
申请日:2018-06-21
Applicant: Hitachi High-Technologies Corporation
Inventor: Kenta IMAI , Hiroya UMEKI , Shunsuke SASAKI , Yoshihiro YAMASHITA , Taku SAKAZUME
IPC: G01N35/10 , G01N33/49 , G01N33/493 , G01N35/04
Abstract: There is provided an automatic analysis device that can easily realize introduction and replacement of additional reagents in operation even in a small-scale configuration. The automatic analysis device includes a reagent dispensing mechanism 107 that dispenses a reagent from a reagent container 113 containing a reagent, and a normal reagent storage portion 130 that stores a reagent container and an additional reagent storage portion 111. The normal reagent storage portion 130 is positioned in a normal movable area 132, which is a portion of a movable area 131 of the reagent dispensing mechanism 107 and the additional reagent storage portion 111 is positioned in an area excluding the normal movable area 132 in the movable area 131 of the reagent dispensing mechanism 107. The reagent dispensing mechanism 107 performs an access operation in the normal movable area 132 in the normal operation and performs an access operation to the additional reagent storage portion 111 upon receiving a predetermined instruction.
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