公开(公告)号：US20150086425A1

公开(公告)日：2015-03-26

申请号：US14558102

申请日：2014-12-02

Applicant: Hitachi, Ltd.

Inventor： Toru FUJIMURA ,  Kosuke KUWABARA ,  Tatsuro IDE

IPC: G01N21/05 ,  G01N33/543 ,  G01N21/55

CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N21/55 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2201/061 ,  G01N2201/08

Abstract: The invention makes it possible to measure binding of a biochemical substance with a high throughput and with high sensitivity using a small cell capable of being filled with a small amount of chemical solution. A space between a first substrate and a second substrate such that probes are immobilized on their mutually facing planes is used as a cell that houses a specimen solution. Light is irradiated from a first substrate side, and reflected light is subjected to spectroscopy. Binding of the target with the probe is detected by a wavelength shift in the refection spectrum.

Abstract translation: 本发明能够使用能够填充少量化学溶液的小细胞来测量生物化学物质与高产量和高灵敏度的结合。 使用第一基板和第二基板之间的空间，使得将探针固定在其相互面对的平面上，作为容纳样本溶液的单元。 从第一基板侧照射光，反射光进行光谱分析。 通过反射光谱中的波长偏移来检测靶与探针的结合。

公开(公告)号：US20160153904A1

公开(公告)日：2016-06-02

申请号：US14904208

申请日：2013-09-04

Applicant: HITACHI, LTD.

Inventor： Masaki MUKOH ,  Tatsuro IDE ,  Kentaro OSAWA

IPC: G01N21/47 ,  G01B9/02

CPC classification number: G01N21/4795 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/70

Abstract: There is provided an optical tomographic observation device which has a resolving power which is higher than those of a conventional optical tomographic observation device and a confocal microscope by a simple configuration by applying a homodyne phase diversity detection technology and designing so as to satisfy the following formula when λ is a wavelength of a laser light source, Δλ is a wavelength half width at half maximum, NA is a numerical aperture of an objective optical element, S is an effective area of a photodetector, and M is a detection magnification of a detection surface relative to a condensing surface. 1 NA 2 ≤ k 1 0.886  λ Δλ λ ( NA  1 - NA 2 ) ≤ 0.901  S M 2 0.441 ≤ k 1 ≤ 0.750

Abstract translation: 提供了一种光学断层摄影观察装置，其具有比常规光学断层摄影观察装置和共焦显微镜的分辨率高的分辨率，其通过应用零差相位分集检测技术并进行设计以通过简单的配置满足下列公式 当λ是激光源的波长时，＆Dgr;λ是半波长的半波长，NA是物镜光学元件的数值孔径，S是光电检测器的有效面积，M是检测倍率 相对于冷凝表面的检测表面。 1 NA 2≤k10.886λλ＆Dgr;λλ（NA 1 - NA 2）≤0.901S M 20.441≤k1≤0.750