公开(公告)号：US12171664B2

公开(公告)日：2024-12-24

申请号：US17725046

申请日：2022-04-20

Applicant: Howmedica Osteonics Corp.

Inventor： Sonny Sheth ,  David Arazawa ,  J. Brook Burley ,  Sarah Elizabeth Smith ,  Matthew B. Havener ,  James San Antonio ,  Marc Gilles Long

IPC: A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/02 ,  A61L27/36 ,  A61L27/40 ,  A61L31/00 ,  A61L31/12 ,  A61L31/16 ,  A61L27/26

Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

公开(公告)号：US20240245514A1

公开(公告)日：2024-07-25

申请号：US18436900

申请日：2024-02-08

Applicant: Howmedica Osteonics Corp.

Inventor： Sonny Sheth ,  David Arazawa ,  j. Brook Burley ,  Sarah Elizabeth Smith ,  Matthew B. Havener ,  James San Antonio ,  Marc Gilles Long

IPC: A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/02 ,  A61L27/26 ,  A61L27/36 ,  A61L27/40 ,  A61L31/00 ,  A61L31/12 ,  A61L31/16

CPC classification number: A61F2/28 ,  A61F2/30767 ,  A61F2/4601 ,  A61L27/02 ,  A61L27/025 ,  A61L27/3645 ,  A61L27/365 ,  A61L27/40 ,  A61L31/005 ,  A61L31/127 ,  A61L31/16 ,  A61F2002/2835 ,  A61F2002/3006 ,  A61F2002/30062 ,  A61F2002/3093 ,  A61F2/30965 ,  A61L27/26 ,  A61L2420/02 ,  A61L2420/06 ,  C12N2533/18

Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

公开(公告)号：US12232963B2

公开(公告)日：2025-02-25

申请号：US18436900

申请日：2024-02-08

Applicant: Howmedica Osteonics Corp.

Inventor： Sonny Sheth ,  David Arazawa ,  J. Brook Burley ,  Sarah Elizabeth Smith ,  Matthew B. Havener ,  James San Antonio ,  Marc Gilles Long

IPC: A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/02 ,  A61L27/36 ,  A61L27/40 ,  A61L31/00 ,  A61L31/12 ,  A61L31/16 ,  A61L27/26

Abstract: A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

公开(公告)号：US11154638B2

公开(公告)日：2021-10-26

申请号：US15234239

申请日：2016-08-11

Applicant: Howmedica Osteonics Corp.

Inventor： James Dominic San Antonio ,  Marc Gilles Long

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/46 ,  A61L27/12

Abstract: A method of forming a scaffold is disclosed herein. In some embodiments, a method of forming a scaffold includes dissolving a polymer in a solvent to form a polymer solution; adding additive precipitating agent to the polymer solution; precipitating and expanding the polymer from the polymer solution to form a scaffold; and removing the solvent from the scaffold. In some embodiments, prior to adding the precipitating agent, the method further comprising adding at least one of calcium phosphate or a bioactive additive to the polymer solution to form a mixture including the polymer solution and the at least one of calcium phosphate or bioactive additive.

公开(公告)号：US20170043052A1

公开(公告)日：2017-02-16

申请号：US15234239

申请日：2016-08-11

Applicant: Howmedica Osteonics Corp.

Inventor： James Dominic San Antonio ,  Marc Gilles Long

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/12

CPC classification number: A61L27/18 ,  A61L27/12 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02

Abstract: A method of forming a scaffold is disclosed herein. In some embodiments, a method of forming a scaffold includes dissolving a polymer in a solvent to form a polymer solution; adding additive precipitating agent to the polymer solution; precipitating and expanding the polymer from the polymer solution to form a scaffold; and removing the solvent from the scaffold. In some embodiments, prior to adding the precipitating agent, the method further comprising adding at least one of calcium phosphate or a bioactive additive to the polymer solution to form a mixture including the polymer solution and the at least one of calcium phosphate or bioactive additive.

Abstract translation: 本文公开了形成支架的方法。 在一些实施方案中，形成支架的方法包括将聚合物溶解在溶剂中以形成聚合物溶液; 向聚合物溶液中加入添加剂沉淀剂; 从聚合物溶液中沉淀和膨胀聚合物以形成支架; 并从支架中除去溶剂。 在一些实施方案中，在添加沉淀剂之前，该方法还包括向聚合物溶液中加入至少一种磷酸钙或生物活性添加剂以形成包含聚合物溶液和磷酸钙或生物活性添加剂中的至少一种的混合物。