公开(公告)号：US20220098154A1

公开(公告)日：2022-03-31

申请号：US17426408

申请日：2020-01-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI

IPC: C07D213/85 ,  C07D213/64 ,  C07D213/74 ,  C07C237/04 ,  C07D215/54 ,  C07D221/18 ,  C07D217/26 ,  C07C255/58 ,  C07D239/42 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20210387968A1

公开(公告)日：2021-12-16

申请号：US17426436

申请日：2020-01-30

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ

IPC: C07D401/14 ,  C07D401/12 ,  C07D233/64

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.