公开(公告)号：US20230078112A1

公开(公告)日：2023-03-16

申请号：US17615123

申请日：2020-05-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Paul A. BARSANTI ,  Hilary Plake BECK ,  Melissa FLEURY ,  John E. KNOX ,  Ethan DeNardo MCSPADDEN ,  Brian Thomas JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI ,  Chenbo WANG

IPC: C07D417/14 ,  C07D498/18 ,  C07D417/12

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20220098154A1

公开(公告)日：2022-03-31

申请号：US17426408

申请日：2020-01-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI

IPC: C07D213/85 ,  C07D213/64 ,  C07D213/74 ,  C07C237/04 ,  C07D215/54 ,  C07D221/18 ,  C07D217/26 ,  C07C255/58 ,  C07D239/42 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20210115016A1

公开(公告)日：2021-04-22

申请号：US16631738

申请日：2018-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D215/12 ,  C07D217/18 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

公开(公告)号：US20210002297A1

公开(公告)日：2021-01-07

申请号：US17023980

申请日：2020-09-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

公开(公告)号：US20220340875A1

公开(公告)日：2022-10-27

申请号：US17260936

申请日：2019-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

公开(公告)号：US20210254006A1

公开(公告)日：2021-08-19

申请号：US16972181

申请日：2019-06-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28 ,  A61L29/16 ,  A61L31/16

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

公开(公告)号：US20230303510A1

公开(公告)日：2023-09-28

申请号：US18006991

申请日：2021-07-28

Applicant: Ideaya Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael Patrick DILLON ,  Brian Thomas JONES ,  Luisruben Padilla MARTINEZ

IPC: C07D401/04 ,  C07D207/09 ,  C07D413/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04

CPC classification number: C07D401/04 ,  C07D207/09 ,  C07D413/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04

Abstract: The present invention relates to methods for treating bacterial infections caused by or
Provided and set forth herein are certain cyclized acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I) and Formula II.




Also, provided are pharmaceutical compositions comprising such compounds, and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers, using such compounds and pharmaceutical compositions.

公开(公告)号：US20210387968A1

公开(公告)日：2021-12-16

申请号：US17426436

申请日：2020-01-30

Applicant: IDEAYA Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael DILLON ,  Brian JONES ,  Luisruben P. MARTINEZ

IPC: C07D401/14 ,  C07D401/12 ,  C07D233/64

Abstract: Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20210079001A1

公开(公告)日：2021-03-18

申请号：US16967100

申请日：2019-02-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Hilary Plake BECK ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D487/04

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.

公开(公告)号：US20230039955A1

公开(公告)日：2023-02-09

申请号：US17853647

申请日：2022-06-29

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  James Clifford SUTTON, JR.

IPC: C07D498/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D513/04 ,  C07D519/00

Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2e and R2d have the meanings provided in the specification.