公开(公告)号：US20230078112A1

公开(公告)日：2023-03-16

申请号：US17615123

申请日：2020-05-29

Applicant: IDEAYA Biosciences, Inc.

Inventor： Paul A. BARSANTI ,  Hilary Plake BECK ,  Melissa FLEURY ,  John E. KNOX ,  Ethan DeNardo MCSPADDEN ,  Brian Thomas JONES ,  Luisruben P. MARTINEZ ,  Zhonghua PEI ,  Chenbo WANG

IPC: C07D417/14 ,  C07D498/18 ,  C07D417/12

Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

公开(公告)号：US20230303510A1

公开(公告)日：2023-09-28

申请号：US18006991

申请日：2021-07-28

Applicant: Ideaya Biosciences, Inc.

Inventor： Hilary Plake BECK ,  Michael Patrick DILLON ,  Brian Thomas JONES ,  Luisruben Padilla MARTINEZ

IPC: C07D401/04 ,  C07D207/09 ,  C07D413/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04

CPC classification number: C07D401/04 ,  C07D207/09 ,  C07D413/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04

Abstract: The present invention relates to methods for treating bacterial infections caused by or
Provided and set forth herein are certain cyclized acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I) and Formula II.




Also, provided are pharmaceutical compositions comprising such compounds, and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers, using such compounds and pharmaceutical compositions.