公开(公告)号：US20250147033A1

公开(公告)日：2025-05-08

申请号：US19013056

申请日：2025-01-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  A61K47/64 ,  C07C229/12 ,  C07C271/22 ,  C07C323/22 ,  C07C323/25 ,  C07D207/448 ,  C07D207/456 ,  C07K16/44 ,  G01N33/53

Abstract: Analogs and conjugates of β-Aminoisobutyric Acid (BAIB).

公开(公告)号：US20240053367A1

公开(公告)日：2024-02-15

申请号：US18222429

申请日：2023-07-15

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Mahalakshmi Yerramilli ,  Edward Obare ,  Daniel Wayne Patch

IPC: G01N33/72 ,  G01N21/33 ,  G01N30/86 ,  C12Q1/32

CPC classification number: G01N33/72 ,  G01N21/33 ,  G01N30/8675 ,  C12Q1/32 ,  G01N2333/904

Abstract: Methods and devices for determining the hematocrit of blood samples.

公开(公告)号：US20250147034A1

公开(公告)日：2025-05-08

申请号：US19013094

申请日：2025-01-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  A61K47/64 ,  C07C229/12 ,  C07C271/22 ,  C07C323/22 ,  C07C323/25 ,  C07D207/448 ,  C07D207/456 ,  C07K16/44 ,  G01N33/53

Abstract: Methods for determining renal function in an animal subject, the method including measuring the concentration of β-ammoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.

公开(公告)号：US20210239704A1

公开(公告)日：2021-08-05

申请号：US17188710

申请日：2021-03-01

Applicant: IDEXX LABORATORIES, INC.

Inventor： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

Abstract: Analogs and conjugates of β-Aminoisobutyric Acid (BAIB).

公开(公告)号：US20180120326A1

公开(公告)日：2018-05-03

申请号：US15569619

申请日：2016-05-02

Applicant: IDEXX LABORATORIES, INC.

Inventor： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/53 ,  C07C229/16 ,  C07K16/44

CPC classification number: G01N33/6812 ,  C07C229/16 ,  C07K16/44 ,  G01N33/5308 ,  G01N33/6806 ,  G01N2800/347

Abstract: Methods for determining renal function in an animal subject, the method including measuring the concentration of β-ammoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.