公开(公告)号：US20220221446A1

公开(公告)日：2022-07-14

申请号：US17705924

申请日：2022-03-28

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V.S.N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

IPC: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/68 ,  G01N33/543

Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

公开(公告)号：US20180335423A1

公开(公告)日：2018-11-22

申请号：US15977284

申请日：2018-05-11

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V.S.N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

IPC: G01N33/53 ,  G01N33/543 ,  C07C279/12 ,  C07K16/44 ,  G01N33/68

CPC classification number: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/54366 ,  G01N33/6812

Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

公开(公告)号：US20140242723A1

公开(公告)日：2014-08-28

申请号：US14192956

申请日：2014-02-28

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V.S.N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

IPC: G01N33/53 ,  G01N33/543

CPC classification number: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/54366 ,  G01N33/6812

Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。

公开(公告)号：US20250147033A1

公开(公告)日：2025-05-08

申请号：US19013056

申请日：2025-01-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Mahalakshmi Yerramilli ,  Edward Obare ,  John Joseph Quinn ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  A61K47/64 ,  C07C229/12 ,  C07C271/22 ,  C07C323/22 ,  C07C323/25 ,  C07D207/448 ,  C07D207/456 ,  C07K16/44 ,  G01N33/53

Abstract: Analogs and conjugates of β-Aminoisobutyric Acid (BAIB).

公开(公告)号：US11035861B2

公开(公告)日：2021-06-15

申请号：US15061327

申请日：2016-03-04

Applicant: IDEXX Laboratories, Inc.

Inventor： Mahalakshmi Yerramilli ,  Murthy V S N Yerramilli

IPC: G01N33/68 ,  G01N33/70

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：US09970927B2

公开(公告)日：2018-05-15

申请号：US14192956

申请日：2014-02-28

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V. S. N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

IPC: G01N33/53 ,  G01N33/543 ,  C07C279/12 ,  C07K16/44 ,  G01N33/68

CPC classification number: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/54366 ,  G01N33/6812

Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

公开(公告)号：US20240053367A1

公开(公告)日：2024-02-15

申请号：US18222429

申请日：2023-07-15

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Mahalakshmi Yerramilli ,  Edward Obare ,  Daniel Wayne Patch

IPC: G01N33/72 ,  G01N21/33 ,  G01N30/86 ,  C12Q1/32

CPC classification number: G01N33/72 ,  G01N21/33 ,  G01N30/8675 ,  C12Q1/32 ,  G01N2333/904

Abstract: Methods and devices for determining the hematocrit of blood samples.

公开(公告)号：US11435365B2

公开(公告)日：2022-09-06

申请号：US16571345

申请日：2019-09-16

Applicant: IDEXX Laboratories, Inc.

Inventor： Mahalakshmi Yerramilli ,  Michael Randolph Atkinson ,  Murthy V. S. N. Yerramilli

IPC: G01N33/68 ,  G01N33/53 ,  G01N33/92

Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.

公开(公告)号：US09091684B2

公开(公告)日：2015-07-28

申请号：US13918531

申请日：2013-06-14

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V. S. N. Yerramilli ,  Mahalakshmi Yerramilli ,  Michael Atkinson ,  Kwok Kam Yeung

IPC: G01N33/68 ,  C07K16/44 ,  G01N33/53 ,  C07C279/12 ,  G01N33/543

CPC classification number: G01N33/53 ,  C07C279/12 ,  C07K16/44 ,  G01N33/54366 ,  G01N33/6812

Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.

Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。

公开(公告)号：US20140295464A1

公开(公告)日：2014-10-02

申请号：US14305652

申请日：2014-06-16

Applicant: IDEXX Laboratories, Inc.

Inventor： Mahalakshmi Yerramilli ,  Michael Atkinson ,  Murthy V.S.N. Yerramilli

IPC: G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/74 ,  G01N2333/58 ,  G01N2800/32

Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.

Abstract translation: 用于确定来自猫科动物的血液样品中NT-proBNP的量的方法。 该方法包括通过各种方法检测猫NT-proBNP的降解产物，包括使用抗体，试剂盒和装置。