公开(公告)号：US11913942B2

公开(公告)日：2024-02-27

申请号：US16924081

申请日：2020-07-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Murthy V S N Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  G01N33/542 ,  G01N33/68 ,  C12N9/04

CPC classification number: G01N33/5308 ,  C12N9/0006 ,  G01N33/542 ,  G01N33/6812 ,  C12Y101/01049 ,  G01N2800/347

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US20190120856A1

公开(公告)日：2019-04-25

申请号：US16165337

申请日：2018-10-19

Applicant: IDEXX LABORATORIES, INC.

Inventor： Hongzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy VSN Yerramilli

IPC: G01N33/68 ,  G01N33/563

Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US20240248081A1

公开(公告)日：2024-07-25

申请号：US18390909

申请日：2023-12-20

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  C12N9/04 ,  G01N33/542 ,  G01N33/68

CPC classification number: G01N33/5308 ,  C12N9/0006 ,  G01N33/542 ,  G01N33/6812 ,  C12Y101/01049 ,  G01N2800/347

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US11422136B2

公开(公告)日：2022-08-23

申请号：US16165337

申请日：2018-10-19

Applicant: IDEXX LABORATORIES, INC.

Inventor： Hongzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy V S N Yerramilli

IPC: G01N33/68 ,  G01N33/563 ,  G01N33/60 ,  G01N33/58

Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US20240219379A1

公开(公告)日：2024-07-04

申请号：US18390970

申请日：2023-12-20

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy Yerramilli ,  Dustin Wride ,  Hongzhi Xie ,  William Foster ,  Jennifer Gagner

IPC: G01N33/53 ,  G01N33/543

CPC classification number: G01N33/5308 ,  G01N33/54388 ,  G01N2333/4353 ,  G01N2469/10

Abstract: Immunoassay devices, kits and methods for determining a first analyte in a sample. The device a membrane that supports lateral flow of a liquid, and a dried first detection reagent comprising a first gold nanoparticle having bound thereto (i) a first binding partner for the first analyte, and (ii) a first label, wherein the dried first detection reagent is dried on the membrane and solubilizable by a liquid. Methods using the device to determine analytes in liquid samples.

公开(公告)号：US20210018496A1

公开(公告)日：2021-01-21

申请号：US16924081

申请日：2020-07-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  G01N33/542 ,  G01N33/68 ,  C12N9/04

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US20160245801A1

公开(公告)日：2016-08-25

申请号：US15048209

申请日：2016-02-19

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy VSN Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  C12N9/04

CPC classification number: G01N33/5308 ,  C12N9/0006 ,  C12Y101/01049 ,  G01N33/542 ,  G01N33/6812 ,  G01N2800/347

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

Abstract translation: 均匀免疫测定，可以补偿样品和试剂中固有的背景信号。 使用均质免疫测定法检测生物样品中对称二甲基精氨酸（SDMA）的存在或量。 用于进行测定的试剂和试剂盒。

公开(公告)号：US20220082501A1

公开(公告)日：2022-03-17

申请号：US17232647

申请日：2021-04-16

Applicant: IDEXX Laboratories, Inc.

Inventor： Jennifer E. Gagner ,  Kiamars Hajizadeh ,  Evan M. Peck ,  James R. Salter ,  Paul J. Travers ,  Christopher P. Turmel ,  Yingzi Wu ,  Hongzhi Xie ,  Murthy V.S.N. Yerramilli

IPC: G01N21/64 ,  G01N21/27 ,  G01N33/58 ,  G01N33/542 ,  C07D311/82

Abstract: The present invention relates to a method and reagents for determining the presence of or the amount of an analyte in a sample.

公开(公告)号：US10775365B2

公开(公告)日：2020-09-15

申请号：US15048209

申请日：2016-02-19

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V S N Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  C12N9/04 ,  G01N33/542 ,  G01N33/68

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.