公开(公告)号：US12031174B2

公开(公告)日：2024-07-09

申请号：US16362478

申请日：2019-03-22

Applicant: IDEXX LABORATORIES, INC.

Inventor： Giosi Farace ,  Jon Braff ,  Murthy V S N Yerramilli

IPC: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/02 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52

CPC classification number: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52 ,  G01N2015/0294 ,  G01N2800/26

Abstract: The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

公开(公告)号：US11913942B2

公开(公告)日：2024-02-27

申请号：US16924081

申请日：2020-07-08

Applicant: IDEXX LABORATORIES, INC.

Inventor： Murthy V S N Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  G01N33/542 ,  G01N33/68 ,  C12N9/04

CPC classification number: G01N33/5308 ,  C12N9/0006 ,  G01N33/542 ,  G01N33/6812 ,  C12Y101/01049 ,  G01N2800/347

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.

公开(公告)号：US11422136B2

公开(公告)日：2022-08-23

申请号：US16165337

申请日：2018-10-19

Applicant: IDEXX LABORATORIES, INC.

Inventor： Hongzhi Xie ,  Sreenivasa Rao Ramisetty ,  Murthy V S N Yerramilli

IPC: G01N33/68 ,  G01N33/563 ,  G01N33/60 ,  G01N33/58

Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

公开(公告)号：US11035861B2

公开(公告)日：2021-06-15

申请号：US15061327

申请日：2016-03-04

Applicant: IDEXX Laboratories, Inc.

Inventor： Mahalakshmi Yerramilli ,  Murthy V S N Yerramilli

IPC: G01N33/68 ,  G01N33/70

Abstract: The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.

公开(公告)号：US10775365B2

公开(公告)日：2020-09-15

申请号：US15048209

申请日：2016-02-19

Applicant: IDEXX Laboratories, Inc.

Inventor： Murthy V S N Yerramilli ,  Hongzhi Xie ,  Daniel Wayne Patch ,  Giosi Farace

IPC: G01N33/53 ,  C12N9/04 ,  G01N33/542 ,  G01N33/68

Abstract: Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical Dimethyl Arginine (SDMA) in biological samples. Reagents and kits for conducting the assays.