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公开(公告)号：US09970927B2
公开(公告)日：2018-05-15
申请号：US14192956
申请日：2014-02-28
Applicant: IDEXX Laboratories, Inc.
IPC: G01N33/53 , G01N33/543 , C07C279/12 , C07K16/44 , G01N33/68
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US09091684B2
公开(公告)日：2015-07-28
申请号：US13918531
申请日：2013-06-14
Applicant: IDEXX Laboratories, Inc.
IPC: G01N33/68 , C07K16/44 , G01N33/53 , C07C279/12 , G01N33/543
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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公开(公告)号：US20140295464A1
公开(公告)日：2014-10-02
申请号：US14305652
申请日：2014-06-16
Applicant: IDEXX Laboratories, Inc.
Inventor： Mahalakshmi Yerramilli , Michael Atkinson , Murthy V.S.N. Yerramilli
IPC: G01N33/543
CPC classification number: G01N33/54306 , G01N33/74 , G01N2333/58 , G01N2800/32
Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
Abstract translation: 用于确定来自猫科动物的血液样品中NT-proBNP的量的方法。 该方法包括通过各种方法检测猫NT-proBNP的降解产物，包括使用抗体，试剂盒和装置。
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Patent Agency Ranking
公开(公告)号：US20220221446A1
公开(公告)日：2022-07-14
申请号：US17705924
申请日：2022-03-28
Applicant: IDEXX Laboratories, Inc.
Inventor： Murthy V.S.N. Yerramilli , Mahalakshmi Yerramilli , Michael Atkinson , Kwok Kam Yeung
IPC: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/68 , G01N33/543
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US20180335423A1
公开(公告)日：2018-11-22
申请号：US15977284
申请日：2018-05-11
Applicant: IDEXX Laboratories, Inc.
Inventor： Murthy V.S.N. Yerramilli , Mahalakshmi Yerramilli , Michael Atkinson , Kwok Kam Yeung
IPC: G01N33/53 , G01N33/543 , C07C279/12 , C07K16/44 , G01N33/68
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
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公开(公告)号：US20140242723A1
公开(公告)日：2014-08-28
申请号：US14192956
申请日：2014-02-28
Applicant: IDEXX Laboratories, Inc.
Inventor： Murthy V.S.N. Yerramilli , Mahalakshmi Yerramilli , Michael Atkinson , Kwok Kam Yeung
IPC: G01N33/53 , G01N33/543
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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公开(公告)号：US20130280740A1
公开(公告)日：2013-10-24
申请号：US13918531
申请日：2013-06-14
Applicant: IDEXX Laboratories, Inc.
Inventor： Murthy V.S.N. Yerramilli , Mahalakshmi Yerramilli , Michael Atkinson , Kwok Kam Yeung
CPC classification number: G01N33/53 , C07C279/12 , C07K16/44 , G01N33/54366 , G01N33/6812
Abstract: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a suitable conjugation target which can be, for example, a protein containing molecule of a label. The anti-SDMA antibodies can be used in diagnostic immunoassay for the diagnosis of SDMA associated disorders and/or diseases.
Abstract translation: 检测生物样品中对称二甲基精氨酸（SDMA）的方法。 SDMA类似物用于产生与不对称的二甲基精氨酸，精氨酸和单甲基精氨酸几乎没有或没有交叉反应性的抗SDMA抗体。 类似物具有受保护或游离的硫醇（-SH）基团或羟基（-OH）基团，其允许它们连接到合适的缀合靶标，其可以是例如含蛋白质的标记分子。 抗SDMA抗体可用于诊断免疫测定以诊断SDMA相关疾病和/或疾病。
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公开(公告)号：US20130274453A1
公开(公告)日：2013-10-17
申请号：US13918465
申请日：2013-06-14
Applicant: IDEXX Laboratories, Inc.
Inventor： Mahalakshmi Yerramilli , Michael Atkinson , Murthy V.S.N. Yerramilli
IPC: G01N33/543
CPC classification number: G01N33/54306 , G01N33/74 , G01N2333/58 , G01N2800/32
Abstract: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.
Abstract translation: 用于确定来自猫科动物的血液样品中NT-proBNP的量的方法。 该方法包括通过各种方法检测猫NT-proBNP的降解产物，包括使用抗体，试剂盒和装置。
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