公开(公告)号：US09681844B2

公开(公告)日：2017-06-20

申请号：US14315520

申请日：2014-06-26

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Jiawei Xu ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492

CPC classification number: A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

公开(公告)号：US11369275B2

公开(公告)日：2022-06-28

申请号：US16709908

申请日：2019-12-10

Applicant: IMEC VZW ,  STICHTING IMEC NEDERLAND

Inventor： Shuang Song ,  Jiawei Xu ,  Roland Van Wegberg ,  Nick Van Helleputte

IPC: A61B5/0295 ,  A61B5/0205 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/024

Abstract: A device for read-out of a photoplethysmography (PPG) signal comprises: a photodiode, which is configured to detect a PPG signal, the photodiode comprising a first and a second terminal; and a read-out circuitry for reading out the PPG signal, wherein an input stage is connected to receive a first and a second input signal from the terminals and a DC bias voltage, and wherein the input stage is configured for current sensing to provide a fully differential amplification of the input signals to a first and a second current signal, and wherein an output stage is configured to receive the current signals, wherein the current signals comprise an AC and a DC component of the PPG signal, and wherein the output stage is configured to generate a differential output voltage through a gain component.

公开(公告)号：US11864876B2

公开(公告)日：2024-01-09

申请号：US16886714

申请日：2020-05-28

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven ,  Stichting IMEC Nederland

Inventor： Qiuyang Lin ,  Jiawei Xu ,  Shuang Song ,  Nick Van Helleputte ,  Filip Tavernier

IPC: A61B5/024 ,  A61B5/00 ,  G01J1/44

CPC classification number: A61B5/02427 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/6826 ,  G01J1/44 ,  G01J2001/446

Abstract: A light-to-digital converter (2) comprises a light-to-current converter (10); a current integrator (4) with an integrator output (30) resettable to a baseline level; and a counter (18) with a digital output (26), wherein the light-to-current converter (10) is switchably connectable as a positive integration input to the current integrator (4), for, during a light-collecting phase (404-406), integrating a current from the light-to-current converter (10), the integrator output (30) starting from the baseline value and ending at a value to be digitized; a reference current source (14) is switchably connectable as a negative integration input to the current integrator (4), for, during a counting phase (406-408) subsequent to the light-collecting phase (404-406), integrating a reference current from the reference current source (14), the integrator output (30) starting from the value to be digitized and ending at the baseline value, the time spent integrating the reference current corresponding to the value to be digitized; and the counter (18) is configured for measuring the time.

公开(公告)号：US20150005585A1

公开(公告)日：2015-01-01

申请号：US14315520

申请日：2014-06-26

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Jiawei Xu ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/0476 ,  A61B5/04 ,  A61B5/0496 ,  A61B5/0428 ,  A61B5/0402 ,  A61B5/0488

CPC classification number: A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

Abstract translation: 一种生物电势信号采集系统，包括：第一有源电极，包括集成前置放大器和模数转换器; 包括集成前置放大器和模数转换器的第二有源电极，其中所述第二有源电极具有可变增益; 测试信号发生器，用于产生测试频率的测试信号，并将测试信号耦合到第一和/或第二有源电极; 以及数字信号处理器，被配置为：处理第一和第二有源电极的数字输出，以基于在测试频率处的第一和第二有源电极输出之间的差异导出增益控制信号，并将增益控制信号施加到 第二活性电极。 本公开还涉及电子电路或装置以及生物电势信号采集方法。

公开(公告)号：US20170071552A1

公开(公告)日：2017-03-16

申请号：US15247172

申请日：2016-08-25

Applicant: Stichting IMEC Nederland

Inventor： Pieter Harpe ,  Jiawei Xu

IPC: A61B5/00 ,  A61B5/0402 ,  A61B5/0205

CPC classification number: A61B5/7278 ,  A61B5/0205 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/7225 ,  A61B5/725 ,  A61B5/7257 ,  G01N27/026 ,  G01N33/4836

Abstract: The present disclosure is directed to an impedance spectroscopy system for bio-impedance measurement. The impedance spectroscopy system includes a signal generator configured to generate a signal with a broadband frequency spectrum and to generate an analog injection current from the signal with the broadband frequency spectrum. The analog injection current has a high pass frequency characteristic. The impedance spectroscopy system also includes an amplifier configured to measure a voltage signal in response to the analog injection current and to simultaneously measure a biopotential signal. Further, the impedance spectroscopy system includes a processor configured to analyze the voltage signal to derive a bio-impedance spectrum as well to derive further information from the biopotential signal.

Abstract translation: 本公开涉及用于生物阻抗测量的阻抗谱系统。 阻抗谱系统包括信号发生器，其被配置为产生具有宽带频谱的信号并且从具有宽带频谱的信号产生模拟注入电流。 模拟注入电流具有高通频特性。 阻抗谱系统还包括放大器，其被配置为响应于模拟注入电流测量电压信号并同时测量生物电位信号。 此外，阻抗光谱系统包括处理器，其被配置为分析电压信号以导出生物阻抗谱，以及从生物电位信号导出进一步的信息。

公开(公告)号：US11096629B2

公开(公告)日：2021-08-24

申请号：US15247172

申请日：2016-08-25

Applicant: Stichting IMEC Nederland

Inventor： Pieter Harpe ,  Jiawei Xu

IPC: A61B5/00 ,  A61B5/0537 ,  G01N27/02 ,  G01N33/483 ,  A61B5/30 ,  A61B5/318 ,  A61B5/0205 ,  A61B5/053

Abstract: The present disclosure is directed to an impedance spectroscopy system for bio-impedance measurement. The impedance spectroscopy system includes a signal generator configured to generate a signal with a broadband frequency spectrum and to generate an analog injection current from the signal with the broadband frequency spectrum. The analog injection current has a high pass frequency characteristic. The impedance spectroscopy system also includes an amplifier configured to measure a voltage signal in response to the analog injection current and to simultaneously measure a biopotential signal. Further, the impedance spectroscopy system includes a processor configured to analyze the voltage signal to derive a bio-impedance spectrum as well to derive further information from the biopotential signal.

公开(公告)号：US10694971B2

公开(公告)日：2020-06-30

申请号：US15689930

申请日：2017-08-29

Applicant: Stichting IMEC Nederland

Inventor： Jiawei Xu

IPC: A61B5/05 ,  A61B5/053 ,  A61B5/00 ,  H03F3/45 ,  A61B5/04 ,  A61B5/0408 ,  A61B5/0478

Abstract: According to an aspect of the present inventive concept there is provided a reconfigurable sensor circuit comprising: an input stage including a first input terminal and a second input terminal, and an amplification stage including: a first amplifier having a non-inverting input, an inverting input and an output connected to the inverting input of the first amplifier via a first resistor, a second amplifier having a non-inverting input, an inverting input and an output connected to the inverting input of the second amplifier via a second resistor, and first switching circuitry adapted to be arranged in a first state, wherein the amplification stage is in a differential amplifier configuration, and in a second state, wherein the amplification stage is in a transimpedance amplifier configuration, wherein, in the differential amplifier configuration, the first amplifier and the second amplifier are together configured as a differential amplifier connected to the first and the second input terminals, and wherein, in the transimpedance amplifier configuration, at least the first amplifier is configured as a transimpedance amplifier connected to the first input terminal.