公开(公告)号：US20220226292A1

公开(公告)日：2022-07-21

申请号：US17578968

申请日：2022-01-19

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Shashank Tripathi ,  Rohan Narayan ,  Abhijith Biji ,  R.S. Rajmani

IPC: A61K31/4402 ,  A61P31/16

Abstract: The present disclosure provides methods for inhibiting entry of a virus into a host cell using picolinic acid or a salt or derivative thereof. The present disclosure also provides methods for treating or preventing a viral infection in a subject by administering picolinic acid or a salt or derivative thereof. In particular, the methods of the present disclosure are effective for enveloped viruses and syncytium-forming viruses. In some embodiments, the present disclosure provides methods of treating or preventing a SARS CoV-2, Influenza A virus, human parainfluenza virus, herpes simplex virus, Japanese encephalitis virus, Zika virus, or a flavivirus infection.

公开(公告)号：US12268676B2

公开(公告)日：2025-04-08

申请号：US17578968

申请日：2022-01-19

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Shashank Tripathi ,  Rohan Narayan ,  Abhijith Biji ,  R. S. Rajmani

IPC: A61K31/4402 ,  A61P31/16

Abstract: The present disclosure provides methods for inhibiting entry of a virus into a host cell using picolinic acid or a salt or derivative thereof. The present disclosure also provides methods for treating or preventing a viral infection in a subject by administering picolinic acid or a salt or derivative thereof. In particular, the methods of the present disclosure are effective for enveloped viruses and syncytium-forming viruses. In some embodiments, the present disclosure provides methods of treating or preventing a SARS CoV-2, Influenza A virus, human parainfluenza virus, herpes simplex virus, Japanese encephalitis virus, Zika virus, or a flavivirus infection.