公开(公告)号：US12270319B2

公开(公告)日：2025-04-08

申请号：US18553951

申请日：2022-04-05

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Pramod Kumar ,  Siddhant Karmarkar

IPC: F01K25/10 ,  F01K7/32

Abstract: A system for generating mechanical power using super critical carbon dioxide (sCO2) is disclosed. The system includes at least one expansion cylinder (5) housing a first piston (5a) and at least one compression cylinder (6) housing a second piston (6a). A first heat exchanger (C) is fluidically connected to the compression cylinder (6) and the expansion cylinder (5), and a second heat exchanger (H) is fluidically connected to the compression cylinder (6) and the expansion cylinder (5). The first heat exchanger (C) cools the CO2 received from the expansion cylinder (5), and the compression cylinder (6) pressurizes the CO2 cooled by the first heat exchanger (C). The second heat exchanger (H) heats the CO2 from the compression cylinder (6) and supplies to the expansion cylinder (5). The high temperature and high-pressure CO2 drives the first piston (5a) housed inside the expansion cylinder (5) to generate mechanical energy.

公开(公告)号：US12209553B2

公开(公告)日：2025-01-28

申请号：US18259956

申请日：2021-12-28

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Pramod Kumar ,  Siddhant Karmarkar ,  Vijay Biradar

IPC: F02G1/044 ,  F01B7/16 ,  F01B31/08 ,  F01K25/10

Abstract: The present disclosure relates to an engine (100) including a cylinder (102) that is filled with carbon dioxide. A first piston (104) is slidably configured inside the cylinder (102) and being configured to form a first cylinder (108) with a first end (130) of the cylinder (102). A second piston (106) is slidably configured inside the cylinder (102) and being configured to form a second cylinder (110) with a second end (132) of the cylinder (102). A heater (112) is circumferentially disposed around the first cylinder (108) and the first piston (104) is configured to expand a hot carbon dioxide received inside the first cylinder (108) from the heater (112). A cooler (116) is circumferentially disposed around the second cylinder (110) and second piston (104) is configured to compress a cold carbon dioxide received inside the second cylinder (110) from the cooler (116).

公开(公告)号：US11879894B2

公开(公告)日：2024-01-23

申请号：US16891373

申请日：2020-06-03

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Gregor Jose ,  Thomas Pucadyil

IPC: G01N33/58 ,  G01N33/68

CPC classification number: G01N33/582 ,  G01N33/6803 ,  G01N2405/00

Abstract: This invention discloses bi-functional photoactivable fluorescent lipid probes for proximity labelling-based identification of membrane-associated proteins, and synthesis thereof. The photoactivable fluorescent lipid probe include a lipid moiety, a fluorophore, and a photoactivable moiety; where the fluorophore and the photoactivable moiety are covalently attached to the lipid moiety.

公开(公告)号：US20220226292A1

公开(公告)日：2022-07-21

申请号：US17578968

申请日：2022-01-19

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Shashank Tripathi ,  Rohan Narayan ,  Abhijith Biji ,  R.S. Rajmani

IPC: A61K31/4402 ,  A61P31/16

Abstract: The present disclosure provides methods for inhibiting entry of a virus into a host cell using picolinic acid or a salt or derivative thereof. The present disclosure also provides methods for treating or preventing a viral infection in a subject by administering picolinic acid or a salt or derivative thereof. In particular, the methods of the present disclosure are effective for enveloped viruses and syncytium-forming viruses. In some embodiments, the present disclosure provides methods of treating or preventing a SARS CoV-2, Influenza A virus, human parainfluenza virus, herpes simplex virus, Japanese encephalitis virus, Zika virus, or a flavivirus infection.

公开(公告)号：US20220160472A1

公开(公告)日：2022-05-26

申请号：US17434850

申请日：2020-02-28

Applicant: INDIAN INSTITUTE OF SCIENCE ,  DEPARTMENT OF BIOTECHNOLOGY ,  M S RAMAIAH UNIVERSITY OF APPLIED SCIENCES

Inventor： Srimanta BARUI ,  Vibha SHETTY ,  Bikramjit BASU

IPC: A61C8/00

Abstract: A dental implant assembly comprises, a base member which is rotatably insertable into a jaw-bone. The base member may be defined by a collar portion, a mid-portion and an apical region. The base member in entirety may be configured with a tapered configuration right from the mid-portion to the apical region. Further, the base member is defined with a plurality of threaded profiles on an outer surface. A first thread profile is defined on the collar portion. A second thread profile, defined on the mid-portion and a third thread profile, defined on the apical region. The third thread profile is configured to cut into the jaw-bone during insertion to anchor the base member. As the third thread profile cuts in to the jaw bone, the second thread profile forms a threaded hole within the drilled hole in order to securely anchor the base member within the jaw bone.

公开(公告)号：US20220054075A1

公开(公告)日：2022-02-24

申请号：US17443527

申请日：2021-07-27

Applicant: Indian Institute of Science Education and Research

Inventor： Nixon Mundathukudiyil ABRAHAM

IPC: A61B5/00 ,  G01N33/00

Abstract: The present disclosure relates to an apparatus (100) for quantitative assessment of olfactory dysfunctions and neurocognitive deficits, the apparatus includes first filters (104-1) adapted to sterilize air received from an air pump, a second filter (106) filter odor molecules from the air, a manifold (108) adapted to split the sterilized air into a plurality of channels, at least one channel carries the sterilized air to a first MFC (110) and adjacent channels carry sterilized air to second MFCs (112). Each container in a reservoir (114) filled with an odorant different from adjacent containers, and a nozzle (118) adapted to receive the odorized air from the reservoir that is inhaled by a subject through an odor delivery unit (124), based on degree of variation in volumetric concentration of the odorants, quantitative assessment of olfactory dysfunction is determined.

公开(公告)号：US20220020871A1

公开(公告)日：2022-01-20

申请号：US17309583

申请日：2019-12-05

Applicant: Indian Institute of Science

Inventor： Srinivasan RAGHAVAN ,  Navakanta BHAT ,  Rohith SOMAN

IPC: H01L29/778 ,  H01L29/06

Abstract: The present subject matter provides a High Mobility Electron Transistor (HEMT) comprising: a substrate, a nucleation layer provided on the substrate, a channel layer, and a buffer layer formed between the nucleation layer and the channel layer. The buffer layer comprises a vertical stack of p-n junctions. Each p-n junction of the vertical stack of p-n junctions comprises an n-type layer provided on a p-type layer. The n-type layer and the p-type layer are parallel to the substrate.

公开(公告)号：US11221339B2

公开(公告)日：2022-01-11

申请号：US16467229

申请日：2017-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Raghavan Varadarajan ,  Tariq Ahmad Najar ,  Rohini Datta

IPC: C40B30/04 ,  G01N33/68 ,  C12N15/10 ,  C40B40/02

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

公开(公告)号：US11217662B2

公开(公告)日：2022-01-04

申请号：US16609125

申请日：2018-04-27

Applicant: Indian Institute of Science

Inventor： Anshu Pandey ,  Biswajit Bhattacharyya ,  Guru Pratheep Rajasekar ,  Amit Kumar Simlandy

IPC: H01L31/0352 ,  H01L29/04 ,  B01J23/08 ,  H01L31/032 ,  H01L31/0336

Abstract: Present subject matter provides a semiconductor nanocrystal comprises a core and a shell. The core is fabricated from a first semiconductor. The shell is fabricated from a second semiconductor. The optical cross section of the semiconductor nanocrystal is in a range of 10−17 cm2-10−12 cm2 in a 2-3 eV region. The core is less than 2 nanometers from an outer surface of the shell in at least one region of the semiconductor nanocrystal. Present subject matter also provides method for preparation of the semiconductor nanocrystals and method for photosynthesis of organic compounds.

公开(公告)号：US20210163916A1

公开(公告)日：2021-06-03

申请号：US16771124

申请日：2018-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sandanaraj Selvaraj BRITTO ,  Pavankumar Janardhan BHANDARI ,  Mullapudi Mohan REDDY

IPC: C12N9/96 ,  C08G83/00 ,  A61K47/60 ,  C12N9/76 ,  C12N9/64

Abstract: The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.