公开(公告)号：US07179637B2

公开(公告)日：2007-02-20

申请号：US10225057

申请日：2002-08-21

Applicant: Ilya Feygin ,  Rafail Kushak

Inventor： Ilya Feygin ,  Rafail Kushak

IPC: C12M3/00

CPC classification number: B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00756 ,  Y10S623/915 ,  Y10S623/917

Abstract: An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving enclosure that is capable of interfacing (e.g., via transfer of fluids, electronically, etc.) with a variety of preparative devices and analytical instrumentation. In some variations, the tissue-receiving enclosure is formed from two housings, which, when engaged, have a capsular shape. The enclosure receives a tissue sample in the form of an un-everted or everted intestinal segment or tubular artificial membrane. The tissue sample is coupled to a generally cylindrical tissue support. The tissue support and the enclosure are axially aligned, and openings at the ends of the enclosure align with openings at the ends of the tissue support. Two feed fittings, one for each end of the enclosure, forcefully mate with the aligned openings in the housing and the tissue support. The feed fitting seals against the ends of the tissue support, forming “outer” and “inner” chambers within the enclosure, with the intestinal tissue being the interface between the chambers. It is across this interface that absorption occurs.

Abstract translation: 用于在与体内条件非常相似的受控环境中高通量分析化合物吸收的装置。 该装置包括至少一个能够与各种制备装置和分析仪器进行接口（例如通过流体，电子传递等）接触的组织接收外壳。 在一些变型中，组织接收外壳由两个外壳形成，当外壳接合时，其具有荚膜形状。 外壳接收非直肠或直肠肠段或管状人造膜形式的组织样本。 组织样本联接到大致圆柱形的组织支撑。 组织支撑件和外壳被轴向对齐，并且外壳端部处的开口与组织支撑件端部处的开口对齐。 两个进给配件，一个用于外壳的每一端，与壳体和组织支撑件中对齐的开口强制配合。 进料配件密封组织支撑件的端部，在外壳内形成“外”和“内”腔，肠组织是腔室之间的界面。 在这个界面上，吸收发生。

公开(公告)号：US06890491B1

公开(公告)日：2005-05-10

申请号：US08872097

申请日：1997-06-10

Applicant: Ilya Feygin ,  Rhett L. Affleck ,  Leslie A. Walling ,  Peter Kieselbach ,  Gregory Louis Kirk ,  Ian Henderson

Inventor： Ilya Feygin ,  Rhett L. Affleck ,  Leslie A. Walling ,  Peter Kieselbach ,  Gregory Louis Kirk ,  Ian Henderson

IPC: B01J19/00 ,  B01L3/00 ,  C40B60/14 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC classification number: B01L3/565 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00326 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  C40B60/14 ,  G01N35/025 ,  G01N35/10 ,  G01N2035/00534 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: A universal fluid exchange device includes upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.

Abstract translation: 通用流体交换装置包括上部和下部反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。 反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。 反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到 适当的接收船只。 该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

公开(公告)号：US06644364B1

公开(公告)日：2003-11-11

申请号：US10088150

申请日：2002-03-13

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B65B105

CPC classification number: B01L3/0265 ,  B01J3/002 ,  B01J3/03 ,  B01J4/02 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00585 ,  B01L2200/025 ,  B01L2200/146 ,  B01L2400/0633 ,  B01L2400/082 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/1041 ,  G01N2035/1044

Abstract: A multi-channel fluid dispenser includes a reservoir (106) with multiple internal chambers (844) with ports (850) to fill each chamber (844), a multi-channel liquid dispensing head, a plurality of fluid-delivery conduits, and support and positioning elements.

Abstract translation: 多通道流体分配器包括具有多个内室（844）的储存器（106），其具有用于填充每个室（844）的端口（850），多通道液体分配头，多个流体输送管道和支撑件 和定位元件。

公开(公告)号：US06622315B1

公开(公告)日：2003-09-23

申请号：US10263934

申请日：2002-10-03

Applicant: Ilya Feygin ,  Mark Rozentsvayg

Inventor： Ilya Feygin ,  Mark Rozentsvayg

IPC: E03D900

CPC classification number: A47K13/302 ,  A47K13/30 ,  E03D9/005

Abstract: A toilet bowl deodorizing, disinfecting and washing apparatus. In one variation, the apparatus includes a flexible enclosure that contains a bellows, a high-pressure reservoir, a liquid reservoir, and a plurality of nozzles. The bellows, liquid reservoir, and nozzles are selectively placed in fluid communication with the high-pressure reservoir. In use, the flexible enclosure is disposed beneath a toilet seat (or is itself a toilet seat). Deodorizing/disinfecting/washing liquid, which is contained in the liquid reservoir, is admitted to the high-pressure reservoir. When a person sits on the flexible enclosure, the bellows compresses air that is admitted to the high-pressure reservoir, thereby pressurizing the deodorizing/disinfecting/washing liquid that is contained therein. As the person gets off the flexible enclosure, the high-pressure reservoir is connected to the nozzles such that pressurized deodorizing/disinfecting/washing liquid is dispensed.

Abstract translation: 厕所除臭，消毒和洗涤设备。 在一个变型中，该装置包括容纳波纹管，高压储存器，液体储存器和多个喷嘴的柔性外壳。 波纹管，液体储存器和喷嘴选择性地与高压储存器流体连通。 在使用中，柔性外壳设置在马桶座下方（或本身为马桶座）。 包含在液体储存器中的除臭/消毒/洗涤液体被允许进入高压储存器。 当一个人坐在柔性外壳上时，波纹管压缩进入高压储存器的空气，从而对包含在其中的除臭/消毒/洗涤液体进行加压。 当人脱离柔性外壳时，高压储存器连接到喷嘴，从而分配加压除臭/消毒/清洗液体。

公开(公告)号：US08277762B2

公开(公告)日：2012-10-02

申请号：US10566648

申请日：2004-07-30

Applicant: John M. Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert Dominic King-Smith

Inventor： John M. Newsam ,  Ilya Feygin ,  Samir Mitragotri ,  Robert Dominic King-Smith

IPC: B01L3/00

CPC classification number: G01N21/253 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2300/045 ,  B01L2300/0609 ,  B01L2300/0618 ,  B01L2300/0829 ,  B01L2400/0611 ,  B01L2400/0633 ,  B01L2400/065 ,  G01N13/00 ,  G01N21/03 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/78 ,  G01N33/5082 ,  Y10T436/255

Abstract: The present invention teaches apparatus (511) and methods for screening the effect of test formulations on the barrier properties of a membrane (212), that are especially beneficial when skin is used as the test membrane (212). The apparatus (511) and methods enable more efficient measurements of skin permeabilization, of the permeation of molecular or particulate entities through skin, and of the absorption and adsorption by skin of ingredients in fluid formulations, together with screening of exfoliation of material from the exterior of the stratum corneum. The apparatus (511) provide for fluid contact to the skin from both donor and receptor sides, for measurements of skin electrical response in the presence of test formulations, of permeation and permeation enhancement, for the depth profiling of test formulation constituents through the skin, of stratum corneum component disruption, and of loss of material from the stratum corneum.

Abstract translation: 本发明教导了用于筛选试验制剂对膜（212）的阻隔性能的影响的装置（511），当皮肤用作测试膜时（212）是特别有利的。 装置（511）和方法能够更有效地测量皮肤透化，分子或颗粒物质通过皮肤的渗透，以及流体配方中成分的皮肤吸收和吸附以及从外部筛选材料的剥离 的角质层。 设备（511）提供从供体和受体侧的流体接触皮肤，用于在测试制剂存在下测量皮肤电响应，渗透和渗透增强，用于通过皮肤测试制剂成分的深度分布， 的角质层组分破坏，以及角质层材料的损失。

公开(公告)号：US07579194B2

公开(公告)日：2009-08-25

申请号：US10769220

申请日：2004-01-30

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: G01N21/00

CPC classification number: G01N21/35 ,  G01N21/3563

Abstract: An apparatus and method for monitoring a large number of binding interactions and obtaining data related to the interactions. In accordance with the illustrative embodiment, the apparatus includes an IR sensor, a sliding separator, and IR-transmitting fibers that are optically coupled, at a first end thereof, to the sensor. The sliding separator adjusts the spacing between fibers as is required for interfacing the second end of the fibers with any of a variety of sample carriers. The second end of the fibers capture chemical entities form the sample carriers. The chemical entities at the end of the fibers are then contacted with a binding compound. If binding activity occurs, a thermal signal indicative thereof will be transmitted through the fiber to the sensor.

Abstract translation: 用于监测大量结合相互作用并获得与相互作用相关的数据的装置和方法。 根据说明性实施例，该装置包括IR传感器，滑动分离器和IR传输光纤，其在其第一端光耦合到传感器。 滑动分离器调节纤维之间的间距，如将纤维的第二端与各种样品载体中的任何一个接合所需要的。 纤维的第二端捕获化学实体形成样品载体。 然后将纤维末端的化学实体与结合化合物接触。 如果发生结合活动，则表示其的热信号将通过光纤传输到传感器。

公开(公告)号：US06846461B2

公开(公告)日：2005-01-25

申请号：US09873087

申请日：2001-06-01

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L99/00 ,  B01J19/00 ,  B01L3/00 ,  C40B60/14 ,  G01N1/00 ,  B01L11/00 ,  F16K11/00 ,  G01N1/10

CPC classification number: G01N35/1097 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01L3/567 ,  C40B60/14 ,  Y10T137/4259 ,  Y10T137/7293 ,  Y10T436/2575

Abstract: A U-valve apparatus including a bidirectional check valve for controlling the flow of liquid from a vessel while preventing inadvertent discharge from the vessel. The check valve allows passage of a fluid such a gas into the vessel, for purposes of agitating the liquid or for other purposes, and also permits the evacuation of the liquid from the vessel. The U-valve apparatus is advantageously included in a universal fluid exchange device including upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. Each of one or more reaction vessels may suitably be connected by a U-valve apparatus including a check valve to a corresponding receiving vessel. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.

Abstract translation: 一种U型阀装置，包括用于控制来自容器的液体流动的双向止回阀，同时防止从容器中泄漏。 止回阀允许流体例如气体进入容器，用于搅拌液体或用于其它目的，并且还允许从容器排出液体。 U型阀装置有利地包括在通用流体交换装置中，包括上和下反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。 反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。 一个或多个反应容器中的每一个可以适当地通过包括止回阀的U形阀装置连接到相应的接收容器。 反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到 适当的接收船只。 该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

公开(公告)号：US06575364B1

公开(公告)日：2003-06-10

申请号：US09225533

申请日：1999-01-04

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: G06K708

CPC classification number: G06K19/06196

Abstract: A magnetically recordable label embedded within a plastic object such as a microtiter plate. The label comprises a magnetic recording medium such as a recording wire, and is concealed within the object or within a sealed enclosure attached to the object. The label can be written to or read from by a recording head passing adjacent to the label. Because the label is completely enclosed, it is shielded from degrading effects that may be present in the environment.

Abstract translation: 嵌入在诸如微量滴定板之类的塑料物体内的磁性可记录标签。 标签包括诸如记录线的磁记录介质，并且被隐藏在物体内或在附接到物体的密封外壳内。 标签可以通过与标签相邻的记录头来写入或读取。 因为标签是完全封闭的，所以可以避免环境中可能存在的恶化效应。

公开(公告)号：US06410342B1

公开(公告)日：2002-06-25

申请号：US08914861

申请日：1997-08-19

Applicant: Rhett L. Affleck ,  Doug Hobbs ,  Ilya Feygin ,  Gregory L. Kirk ,  James A. Connelly ,  Ning Zhao ,  James P. Mueller ,  Peter Kieselbach

Inventor： Rhett L. Affleck ,  Doug Hobbs ,  Ilya Feygin ,  Gregory L. Kirk ,  James A. Connelly ,  Ning Zhao ,  James P. Mueller ,  Peter Kieselbach

IPC: G01N33543

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00713 ,  B01J2219/0072 ,  C07K1/04 ,  C07K1/12 ,  C40B60/14 ,  G01N33/54353

Abstract: A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.

Abstract translation: 公开了一种光可剥离接头连接的化合物的光洗脱方法，以及适用于实施该方法的装置。 根据该方法，可光裂解的连接物连接的文库化合物在受控的曝光和受控温度的条件下从固体支持介质中光固化。 适用于实施本发明的光洗涤方法的装置包括用于基本均匀地照射可光切割接头的装置，用于控制照明时间和强度的装置，以及用于控制样品温度的装置。

公开(公告)号：US6158146A

公开(公告)日：2000-12-12

申请号：US533877

申请日：2000-03-22

Applicant: Peter Kieselbach ,  Ilya Feygin ,  Joseph J. Brzezinski ,  Gregory L. Kirk ,  Thuc Nguyen ,  Joseph A. Mollica

Inventor： Peter Kieselbach ,  Ilya Feygin ,  Joseph J. Brzezinski ,  Gregory L. Kirk ,  Thuc Nguyen ,  Joseph A. Mollica

IPC: F26B5/04 ,  F26B9/06 ,  F26B21/00 ,  F26B21/14

CPC classification number: F26B5/044 ,  F26B21/004 ,  F26B21/14

Abstract: A dryer for use with chemical compounds employs controlled vacuum, elevated temperature and dry, inert gas to dry the chemical compounds. The dryer includes a vacuum chamber into which trays containing the compounds are placed. The chamber includes heating elements which elevate the temperature of chemical samples placed within the chamber. Supplying and evacuating manifolds, each with a plurality of orifices for supplying and evacuating dry inert gas, provide a substantially laminar flow of dry inert gas just above the trays of chemical compounds which are to be dried. The laminar gas flow removes the unwanted vapor which tends to form above the tray of chemical compound, thus accelerating the drying process.

Abstract translation: 与化学化合物一起使用的干燥器采用受控真空，高温和干燥，惰性气体来干燥化学化合物。 干燥机包括一个真空室，其中放置含有化合物的托盘。 该腔室包括提升放置在腔室内的化学样品的温度的加热元件。 供应和排空歧管，每个歧管各具有用于供应和排出干燥惰性气体的多个孔，提供干燥惰性气体的基本层流，正好在要干燥的化合物的塔板上方。 层流气流除去易于形成化学化合物塔板上方的不需要的蒸汽，从而加速干燥过程。