公开(公告)号：US20140107331A1

公开(公告)日：2014-04-17

申请号：US14141052

申请日：2013-12-26

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Kenzo Fujimoto ,  Masayuki Ogino ,  Yoshinaga Yoshimura

IPC: C07H21/04 ,  C07H19/073

CPC classification number: C07H21/00 ,  C07H19/073 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention provides a manufacturing method that can easily manufacture a compound known as photoresponsive (photocoupling) nucleic acids at high yield in a shorter period of time than that of the conventional technology. The present invention relates to a method of manufacturing a photoresponsive nucleic acid which includes a step of reacting a nucleic acid having groups represented by the Formula I, the Formula III, the Formula IV, or the Formula V and a compound represented by the Formula II, or reacting a nucleic acid having groups represented by the Formula VI, the Formula VIII, the Formula IX, or the Formula X and a compound represented by the Formula VII by heating them by microwaves in the presence of a metal catalyst, a basic substance, and a solvent.

Abstract translation: 本发明提供了一种制造方法，其可以在比常规技术更短的时间内以高产率容易地制造称为光响应（光耦合）核酸的化合物。 本发明涉及一种制备光响应核酸的方法，其包括使具有由式I，式III，式IV或式V表示的基团的核酸与式II表示的化合物反应的步骤 或通过在金属催化剂，碱性物质的存在下通过微波加热而使具有由式VI，式VIII，式IX或式X表示的基团的核酸和式VII表示的化合物反应 ，和溶剂。

公开(公告)号：US09359393B2

公开(公告)日：2016-06-07

申请号：US14141052

申请日：2013-12-26

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Kenzo Fujimoto ,  Masayuki Ogino ,  Yoshinaga Yoshimura

IPC: C07H21/02 ,  C07H21/04 ,  C07H21/00 ,  C07H19/073

CPC classification number: C07H21/00 ,  C07H19/073 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention provides a manufacturing method that can easily manufacture a compound known as photoresponsive (photocoupling) nucleic acids at high yield in a shorter period of time than that of the conventional technology. The present invention relates to a method of manufacturing a photoresponsive nucleic acid which includes a step of reacting a nucleic acid having groups represented by the Formula I, the Formula III, the Formula IV, or the Formula V and a compound represented by the Formula II, or reacting a nucleic acid having groups represented by the Formula VI, the Formula VIII, the Formula IX, or the Formula X and a compound represented by the Formula VII by heating them by microwaves in the presence of a metal catalyst, a basic substance, and a solvent.

Abstract translation: 本发明提供了一种制造方法，其可以在比常规技术更短的时间内以高产率容易地制造称为光响应（光耦合）核酸的化合物。 本发明涉及一种制备光响应核酸的方法，其包括使具有由式I，式III，式IV或式V表示的基团的核酸与式II表示的化合物反应的步骤 或通过在金属催化剂，碱性物质的存在下通过微波加热而使具有由式VI，式VIII，式IX或式X表示的基团的核酸和式VII表示的化合物反应 ，和溶剂。