公开(公告)号：US11340215B2

公开(公告)日：2022-05-24

申请号：US16079895

申请日：2017-02-27

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Toru Hirota ,  Yusuke Abe

IPC: G01N33/50 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68 ,  C12N15/113

Abstract: The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1α, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.

公开(公告)号：US20190094207A1

公开(公告)日：2019-03-28

申请号：US16079895

申请日：2017-02-27

Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH

Inventor： Toru Hirota ,  Yusuke Abe

IPC: G01N33/50 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68

Abstract: The inventors have found that the interaction between HP1 and INCENP can serve as an indicator for chromosome instability and established a method for evaluating chromosome instability of cancer cells. The evaluation system can be used for screening of anticancer agent with a new-concept of targeting chromosome instability of cancer cells. The inventors further prepared an antibody for specifically recognizing phosphorylation of serine at position 92 of HP1α, by which the action of Aurora B can be evaluated. The interaction between HP1 and INCENP can be readily evaluated by the antibody.