公开(公告)号：US11685793B2

公开(公告)日：2023-06-27

申请号：US14913374

申请日：2014-08-13

Applicant: JNC CORPORATION

Inventor： Toru Kurabayashi ,  Shigeyuki Aoyama ,  Akihiro Uchida

IPC: C08B3/06 ,  C08J3/14 ,  B01J39/22 ,  B01J39/05 ,  B01J39/26 ,  C08L1/12 ,  B01J20/285 ,  B01J20/24 ,  B01J20/30

CPC classification number: C08B3/06 ,  B01J20/24 ,  B01J20/285 ,  B01J20/3085 ,  B01J39/05 ,  B01J39/22 ,  B01J39/26 ,  C08J3/14 ,  C08L1/12 ,  C08J2301/12

Abstract: One embodiment shows a method for producing porous cellulose particles, including:



(a) dissolving cellulose diacetate into a solvent to prepare a cellulose diacetate solution;
(b) dispersing the cellulose diacetate solution into a medium immiscible with the cellulose diacetate solution to obtain a dispersed system;
(c) cooling the dispersed system;
(d) adding a poor solvent to the cooled dispersed system to precipitate cellulose diacetate particles; and
(e) saponifying the cellulose diacetate particles.

公开(公告)号：US10960380B2

公开(公告)日：2021-03-30

申请号：US15384326

申请日：2016-12-20

Applicant: JNC CORPORATION ,  SofSera Corporation

Inventor： Yoshihiro Matsumoto ,  Akihiro Uchida ,  Yasuto Umeda

IPC: B01J20/282 ,  B01D15/38 ,  B01J20/30 ,  C01B25/32 ,  C07K1/16 ,  C07K16/06 ,  C12N9/36

Abstract: An adsorbent, which can be produced by a method in which a particle size, a pore size, a specific surface area or the like can be easily controlled, and is suitable for isolation of biomolecules. The adsorbent contains aggregates of calcium phosphate-based particles, and has an average pore size of 15 to 36 nanometers and a specific surface area of 40 to 90 m2/mL when measurement is carried out by mercury porosimetry.

公开(公告)号：US08969522B2

公开(公告)日：2015-03-03

申请号：US13929805

申请日：2013-06-28

Applicant: JNC Corporation

Inventor： Akihiro Uchida ,  Shuji Sasaki ,  Akiko Shimatani ,  You Umebayashi ,  Kazushi Ishida

IPC: A61K38/17 ,  C07K14/78

CPC classification number: C07K14/78

Abstract: An object is to provide a method for producing an ever-larger molecular weight collagen-like polypeptide single strand. Another object is to provide a method for controlling a molecular weight of a product to be obtained in desired magnitude upon producing a collagen-like polypeptide single strand. A solution is a method for producing a polypeptide including a step for allowing a condensation reaction of peptide oligomers represented by any one of formulas (1) to (3) (SEQ ID No:1 to SEQ ID No:3), wherein the condensation reaction is carried out in an aqueous solvent containing a phosphate ion in the range of 0 M to less than 0.01 M in the presence of a condensing agent, or a condensing agent and a condensing auxiliary: H-(Pro-Y-Gly)n-OH  (1); H-(Y-Gly-Pro)n-OH  (2); and H-(Gly-Pro-Y)n-OH  (3); wherein, in formulas (1) to (3), Y is hydroxyproline or proline, and n is an integer from 1 to 10.

Abstract translation: 目的是提供一种用于生产越来越大分子量的胶原样多肽单链的方法。 另一个目的是提供一种在产生胶原样多肽单链时控制待获得的产物的分子量的方法。 溶液是一种制备多肽的方法，其包括使式（1）〜（3）中任一项所示的肽低聚物缩合反应的步骤（SEQ ID No：1〜SEQ ID No：3），其中， 在缩合剂或缩合剂和冷凝助剂的存在下，在含有0〜小于0.01M的磷酸根离子的含水溶剂中进行反应：H-（Pro-Y-Gly）n -OH（1）; H-（Y-Gly-Pro）n -OH（2）; 和H-（Gly-Pro-Y）n -OH（3）; 其中，在式（1）〜（3）中，Y为羟脯氨酸或脯氨酸，n为1〜10的整数。