Abstract:
Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which are received genomic sequence reads derived from a biological sample obtained from a user The platform also includes a bioinformatics processing pipeline including a read alignment module configured to generate observed sequence data by aligning the sequence reads relative to a reference sequence, a variant calling module operative to identify observed variants in the observed sequence data, and a variant refinement module for producing a set of refined variants associated with the user. A variant imputation module produces a set of imputed variants associated with the user, and a variant storage module disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of the refined or imputed variants in response to the query.
Abstract:
A method for evaluating an input system interfacing a human user with an electronic device uses empirically determined bi-action times for users to perform a second input action (e.g., pressing a second key) immediately after performing a first input action (e.g., pressing a first key). The bi-action times (or, more generally, n-action times) are used together with a selected interface map which associates input actions (e.g., pressing keys) to corresponding signifiers (e.g., characters) to calculate a peak expert input rate for the input system. One or more optimized interface maps can be found by combining the evaluation method with any of various optimization strategies. For example, one method for optimizing the input system repeatedly changes the interface map and recalculates the peak expert input rate, while another optimization method calculates peak expert input rates for multiple interface maps in parallel. The evaluation and optimization methods apply to a wide variety of users, input devices, and types of communication and control between them.
Abstract:
Systems, platforms, methods and media for providing genomic services axe disclosed. In one example, a system for providing genomic services comprises genomic sequencing equipment configured to generate sequence reads based upon a biological sample obtained from a user, store the sequence reads in a FASTQ storage file, and communicate the FASTQ file electronically to a recipient. The system also includes a genomic services platform which includes a network interface through which the sequence reads are received, and a bioinformatics processing pipeline. The bioinformatics processing pipeline includes a read alignment module configured to generate observed sequence data, and a variant calling module is operative to identify observed variants in the observed sequence data. A variant storage module is disposed to receive a query from network infrastructure of a partner application provider and to provide selected ones of refined variants in response to a query.
Abstract:
Systems, platforms, methods and media for providing genomic services are disclosed. In one example, a genomic services platform comprises a network interface through which genomic sequence reads derived from a biological sample obtained from a user are received. The platform also includes a bioinformatics processing pipeline that includes a read alignment module configured to receive a genomics file from genomic sequencing equipment and use data contained therein to generate observed sequence data by aligning the sequence reads relative to a reference sequence. A variant calling module identifies observed variants in the observed sequence data and stores the observed variants in a variant calling file. A variant refinement module produces genotype data including a set of refined variants associated with the user, and a variant imputation module produces a set of imputed variants associated with the user. The variant imputation module can separate the genotype data into high-quality and low-quality genotypes based on a genotype quality.
Abstract:
According to one embodiment of the present invention, there is provided a data center comprising: a plurality of data center sections, each section having a different predefined level of reliability; and a plurality of sets of applications, each set of applications being populated on one of the plurality of data center sections.
Abstract:
A control system and method for operating a coin redemption machine includes a coin redemption machine functioning as a peripheral device to a separate computer linked to the coin redemption machine through a communications link for reciprocal communication between the coin redemption machine and the computer. The computer controls the activating and deactivating of the coin redemption machine; and the computer and coin redemption machine communicate through commands from the computer, followed by responses from the coin redemption machine.
Abstract:
Disclosed is a permanent recloser simulator feature for use in a single-pole trip capable recloser control. The permanent recloser simulator feature includes a first logic circuit capable of enabling and disabling operation of the permanent recloser simulator feature in response to receipt of a binary logic signal, and a second logic circuit coupled to the first logic circuit where the second logic circuit is configured to provide an indication of a status of a first pole to a logic engine of the single-pole trip capable recloser control. The permanent recloser simulator feature may further include a third logic circuit associated with a second pole, and a fourth logic circuit associated with a third pole where both are coupled to the first logic circuit. Disabling means of the first logic circuit allow the first, second, third and fourth logic circuit to permanently reside in logic of the recloser control.
Abstract:
The centrally located ignition source in a combustion chamber is an electrical conductor spanning the general center of the combustion chamber, with a spark gap at the general center of the conductor. The device may be offset from the combustion chamber centerline, and/or the spark gap may be offset from the conductor center, as required. The centrally located ignition source is particularly well suited for use in an opposed piston engine having a rotary sleeve valve mechanism, with the conductor rotating with the sleeve valve and crossing the combustion chamber between the two pistons. An arcuate commutator section may be disposed upon the exterior of the rotary sleeve valve, with a contact finger making electrical contact between the electrical energy source and the commutator section to supply electrical energy to the ignition source. The device is also suitable for use in stationary installations, e.g., gas furnace combustors, etc.
Abstract:
Foam bedding products including viscoelastic foam having a high airflow value that do not feel hot to the person sleeping on the products. One product is a pillow having a contoured core having sufficient firmness to provide effective support for a user and a hyper soft viscoelastic foam shell surrounding the core having sufficient firmness to maintain the appearance of a conventional pillow when supporting only a pillowcase or other bed coverings. The core may be made of higher density viscoelastic foam or of a resilient foam. Another product may be a mattress topper with or without foam cores for body support carried within slabs of high airflow viscoelastic foam.
Abstract:
A token is manufactured using a combination of minting or casting operations and printing operations. The token comprises a metal base material that is minted or cast to the size and shape desired including embossed or debossed areas at selected locations on the token. In selected recessed or countersunk portions of the token, there are provided thin disks of material capable of carrying printed material such as single-colored or multi-colored pictures or indicia. The imprinted disk portions of the token are covered with a first protective coating and, optionally a second protective coating, that eliminates wear and tear on the printed areas of the token. Additionally or alternatively, the entire token can be covered with an outer coating to minimize wear and tear and preserve the unique designs carried by the token.