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    Device for Filtration of Fluids Therethrough and Accompanying Method
    2.
    发明申请
    Device for Filtration of Fluids Therethrough and Accompanying Method 有权
    流体过滤装置及其附带方法

    公开(公告)号：US20120149021A1

    公开(公告)日：2012-06-14

    申请号：US13144572

    申请日：2010-01-15

    Applicant: Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    Inventor： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC: B03C1/02 ,  C12Q1/68 ,  H01J49/26 ,  C12Q1/18 ,  C12M1/42 ,  G01N33/53 ,  C12Q1/02

    CPC classification number: B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    Abstract translation: 用于从源流体分离目标部件的微流体装置包括通过一个或多个传输通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预定量的源流体被处理或者预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    Microfluidic device and uses thereof
    4.
    发明授权
    Microfluidic device and uses thereof 有权
    微流体装置及其用途

    公开(公告)号：US09156037B2

    公开(公告)日：2015-10-13

    申请号：US13144572

    申请日：2010-01-15

    Applicant: Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    Inventor： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC: C12Q1/68 ,  B03C1/01 ,  B03C1/28 ,  G01N33/543 ,  G01N1/40

    CPC classification number: B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    Abstract: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    Abstract translation: 用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    Method of making an article comprising a silicon body
    9.
    发明授权
    Method of making an article comprising a silicon body 失效
    制造包含硅体的制品的方法

    公开(公告)号：US5391269A

    公开(公告)日：1995-02-21

    申请号：US84689

    申请日：1993-06-29

    Applicant: Jason O. Fiering ,  Barry Miller ,  Joseph Shmulovich

    Inventor： Jason O. Fiering ,  Barry Miller ,  Joseph Shmulovich

    IPC: H01L21/306 ,  G02B6/36 ,  H01L21/3063 ,  B23H3/00

    CPC classification number: H01L21/3063 ,  Y10T29/49169

    Abstract: We have found that etching of a body that comprises exposed Si as well as a Ti-comprising metal layer (e.g., a patterned Ti/Pt layer) in an amine-based anisotropic etchant for Si (e.g., 100.degree. C. EDP) frequently results in undesirable changes in the Ti-comprising metal layer. We have also found that the changes can be substantially reduced or eliminated by electrolytic means, namely, by making the metal layer the anode in an electrolytic cell that contains the etchant.

    Abstract translation: 我们已经发现，在基于胺的各向异性蚀刻剂（例如，100℃EDP）中经常蚀刻包括暴露的Si以及包含Ti的金属层（例如，图案化的Ti / Pt层）的主体 导致含Ti的金属层的不期望的变化。 我们还发现，通过电解方式，即通过在含有蚀刻剂的电解槽中使金属层成为阳极，可以显着地减少或消除这些变化。

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