公开(公告)号：US20050271685A1

公开(公告)日：2005-12-08

申请号：US11113751

申请日：2005-04-25

Applicant: Jay Calvert ,  Shelly Shields ,  David Slade ,  Siao-Kun Welch

Inventor： Jay Calvert ,  Shelly Shields ,  David Slade ,  Siao-Kun Welch

IPC: A61K39/12 ,  C07K14/705 ,  C12N5/071 ,  C12N7/00 ,  C12N7/02 ,  C12N15/86 ,  C12Q1/68 ,  C12N5/06

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  C07K14/70596 ,  C12N5/0686 ,  C12N5/0688 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2710/12051 ,  C12N2770/10051

Abstract: The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.

Abstract translation: 本发明提供与产生允许病毒生长的宿主细胞相关的方法和组合物，特别是猪繁殖与呼吸综合征（PRRS）病毒。

公开(公告)号：US20070116720A1

公开(公告)日：2007-05-24

申请号：US11586328

申请日：2006-10-25

Applicant: Jay Calvert ,  Michael Sheppard ,  Siao-Kun Welch ,  Raymond Rowland ,  Dal-Young Kim

Inventor： Jay Calvert ,  Michael Sheppard ,  Siao-Kun Welch ,  Raymond Rowland ,  Dal-Young Kim

IPC: A61K39/395 ,  A61K39/12

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55577 ,  C07K2319/42 ,  C07K2319/60 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/10021 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10043 ,  C12N2770/10061 ,  G01N33/56983 ,  G01N2333/08

Abstract: The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.

Abstract translation: 本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其中多核苷酸分子缺少至少一种可检测的北美PRRS病毒抗原表位。 本发明还提供包含经遗传修饰的北美PRRS病毒，RNA分子，质粒和包含分离的多核苷酸分子的病毒载体的疫苗。 还提供了进一步包含编码可检测的异源抗原表位的至少一个核苷酸序列的分离的多核苷酸分子，以及包含北美PRRS病毒，RNA分子，质粒和包含这种分离的多核苷酸分子的病毒载体的疫苗。

公开(公告)号：US20060041262A1

公开(公告)日：2006-02-23

申请号：US11133400

申请日：2005-05-19

Applicant: Jay Calvert ,  Steven Greenthal

Inventor： Jay Calvert ,  Steven Greenthal

IPC: A61B17/58

CPC classification number: A61F2/30965 ,  A61B17/72 ,  A61B17/7291 ,  A61B17/80 ,  A61F2/28 ,  A61F2/2803 ,  A61F2/2846 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/40 ,  A61F2/4225 ,  A61F2/4241 ,  A61F2002/2807 ,  A61F2002/2817 ,  A61F2002/30224 ,  A61F2230/0069 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00095 ,  A61F2310/00101 ,  A61F2310/00131 ,  A61F2310/00155 ,  A61L27/04 ,  B21F45/00 ,  B21F45/008 ,  B22F2998/00 ,  B22F3/002

Abstract: The disclosure is directed to a material for in vivo implantation. The material includes a compressed interlaced wire shaped into a form having a porous structure suitable for tissue ingrowth, the interlaced wire compressed from an original starting density to a final density, the final density being greater than the original starting density.

Abstract translation: 本公开涉及用于体内植入的材料。 该材料包括成形为具有适于组织向内生长的多孔结构的形式的压缩交织线，所述交织线从原始起始密度压缩至最终密度，最终密度大于原始起始密度。

公开(公告)号：US20060183113A1

公开(公告)日：2006-08-17

申请号：US11366851

申请日：2006-03-01

Applicant: Jay Calvert ,  Michael Sheppard ,  Siao-Kun Welch ,  Raymond Rowland ,  Dal-Young Kim

Inventor： Jay Calvert ,  Michael Sheppard ,  Siao-Kun Welch ,  Raymond Rowland ,  Dal-Young Kim

IPC: C12Q1/70 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/86

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/53 ,  C12N15/86 ,  C12N2770/10022 ,  C12N2770/10043

Abstract: The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

公开(公告)号：US20060155224A1

公开(公告)日：2006-07-13

申请号：US11370576

申请日：2006-03-08

Applicant: Jay Calvert

Inventor： Jay Calvert

IPC: A61H23/02 ,  A61H7/00

CPC classification number: A61H7/005 ,  A61H7/001 ,  A61H9/005 ,  A61H15/0085 ,  A61H23/0254 ,  A61H23/0263 ,  A61H2201/0111 ,  A61H2201/0153 ,  A61H2201/1418 ,  A61H2201/1678 ,  A61H2201/1685 ,  A61H2207/00

Abstract: The invention relates to a method of operating a percussive massage device for smoothing the skin and fat irregularities associated with any liposuction procedure including suction assisted lipectomy, ultrasonic assisted lipectomy, and direct lipectomy; improving the contour irregularities assisted with any liposuction procedure; preconditioning the skin and fat prior to any liposuction procedure to minimize blood vessel damage; removing scar tissue from patients who have recently undergone any liposuction procedure, and treating skin irregularities due to “cellulite”.

Abstract translation: 本发明涉及一种操作冲击式按摩装置的方法，用于平滑与任何抽脂手术相关的皮肤和脂肪不规则，包括抽吸辅助脂肪切除术，超声辅助脂肪切除术和直接脂肪切除术; 改善用任何抽脂手术辅助的轮廓不规则; 在任何抽脂手术之前预处理皮肤和脂肪，以尽量减少血管损伤; 从最近经历过任何抽脂手术的患者中清除疤痕组织，并治疗由于“脂肪团”引起的皮肤不规则现象。

公开(公告)号：US20050053621A1

公开(公告)日：2005-03-10

申请号：US10893712

申请日：2004-07-16

Applicant: Siao-Kun Welch ,  Jay Calvert ,  Michael O'Hara ,  Xuemei Cao

Inventor： Siao-Kun Welch ,  Jay Calvert ,  Michael O'Hara ,  Xuemei Cao

IPC: A61K39/12 ,  A61K39/295 ,  C07K14/18

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/53 ,  C12N2770/24322 ,  C12N2770/24334

Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.

Abstract translation: 本发明提供了安全的疫苗和制备这种疫苗的方法。 本发明的疫苗含有至少两种相同家族的活突变病毒或编码这种病毒的核酸分子，其中两种病毒或编码核酸添加物中的每一种含有赋予所需表型的突变和病毒中的突变 位于相同的基因组位点，使得突变病毒不能彼此重组以消除突变。