公开(公告)号：US20240400518A1

公开(公告)日：2024-12-05

申请号：US18684629

申请日：2022-08-17

Applicant: KANAPH THERAPEUTICS INC. ,  CYRUS THERAPEUTICS INC.

Inventor： Ha Na YU ,  Young Sook SHIN ,  Dohyun PARK ,  Kyeong Jin YOON ,  Sang Kyun LIM ,  Donggeon KIM ,  Dong Hyuk KI ,  Eun-Jung KIM ,  Joonwoo NAM ,  Wooseok HAN ,  Jihyun YU ,  Ji Eun KIM

IPC: C07D231/22 ,  A61K31/4418 ,  A61K31/4965 ,  A61K31/501 ,  C07D213/87 ,  C07D241/24

Abstract: There is provided a novel compound of Formula I and a use thereof for the prevention or treatment of a disease associated with SOS1. In one aspect of the present invention, the novel compound is useful for the prevention or treatment of a SOS1 mediated disease such as cancer and RASopathy by inhibiting the interaction between SOS1 and RAS family proteins or between SOS1 and RAC1.

公开(公告)号：US20240189306A1

公开(公告)日：2024-06-13

申请号：US18407400

申请日：2024-01-08

Applicant: KANAPH THERAPEUTICS INC.

Inventor： Miyeon KIM ,  Dohyun PARK ,  Dongsu KIM ,  Kyeongjin YOON ,  Sungpil CHOI ,  Sang Kyun LIM ,  Eu Ddeum CHUNG ,  Mijung LEE ,  Dahye JEON ,  Soyeon JANG ,  Kyungik LEE ,  Jinhwan KIM ,  Eunji KIM ,  Jieun MIN ,  Kangwoo LEE ,  Jakyung YOO

IPC: A61K31/497 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/10 ,  C07D491/107 ,  C07D519/00

CPC classification number: A61K31/497 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/10 ,  C07D491/107 ,  C07D519/00

Abstract: The present invention relates to an inhibitor of SHP2, a pharmaceutical composition for preventing or treating a disease related to SHP2 comprising the same, a method for treating and preventing a disease using the same, and a use thereof. Accordingly, the present invention can effectively prevent or treat diseases related to SHP2.