公开(公告)号：US20240400518A1

公开(公告)日：2024-12-05

申请号：US18684629

申请日：2022-08-17

Applicant: KANAPH THERAPEUTICS INC. ,  CYRUS THERAPEUTICS INC.

Inventor： Ha Na YU ,  Young Sook SHIN ,  Dohyun PARK ,  Kyeong Jin YOON ,  Sang Kyun LIM ,  Donggeon KIM ,  Dong Hyuk KI ,  Eun-Jung KIM ,  Joonwoo NAM ,  Wooseok HAN ,  Jihyun YU ,  Ji Eun KIM

IPC: C07D231/22 ,  A61K31/4418 ,  A61K31/4965 ,  A61K31/501 ,  C07D213/87 ,  C07D241/24

Abstract: There is provided a novel compound of Formula I and a use thereof for the prevention or treatment of a disease associated with SOS1. In one aspect of the present invention, the novel compound is useful for the prevention or treatment of a SOS1 mediated disease such as cancer and RASopathy by inhibiting the interaction between SOS1 and RAS family proteins or between SOS1 and RAC1.