公开(公告)号：US11419797B2

公开(公告)日：2022-08-23

申请号：US16958331

申请日：2018-12-27

Applicant: KAO CORPORATION

Inventor： Takashi Suzuki ,  Tetsuya Abe ,  Rui Takahashi ,  Koji Endo ,  Toyoki Hagura ,  Hidetaka Iwai ,  Teruo Horizumi ,  Taisuke Aosaki ,  Akihiro Uda ,  Masato Nakamichi

IPC: A61K8/04 ,  A61K8/34 ,  A61K8/37 ,  A61Q19/00

Abstract: Methods for producing a composition containing a hardly water-soluble aromatic compound are described which involve Step (1), including Step (1-1) for preparing a material comprising: (A) a hardly water-soluble aromatic compound, (B) a polyol, and (C) an aqueous medium, where a content of the (A) hardly water-soluble aromatic compound in the material for heating is below a saturation solubility of the (A) hardly water-soluble aromatic compound in a solvent having the same composition at 25° C. The obtained solution is then heated in Step (1-2) at normal pressure at a temperature of less than 100° C., to obtain a hardly water-soluble aromatic compound solution 1. Step (2) includes adding water to the hardly water-soluble aromatic compound solution 1 such that the resulting hardly water-soluble aromatic compound solution 2 has a concentration of the (A) hardly water-soluble aromatic compound above a saturation solubility at 25° C.

公开(公告)号：US10894058B2

公开(公告)日：2021-01-19

申请号：US15506939

申请日：2015-08-19

Applicant: KAO CORPORATION

Inventor： Masahiro Umehara ,  Akihiro Uda ,  Tetsuya Abe ,  Yasushi Yamada

IPC: A61K31/7048 ,  A61K8/73 ,  A61Q19/02 ,  A61K8/49 ,  A61Q15/00 ,  A61Q7/00 ,  A61Q19/10 ,  A61Q17/04 ,  A61Q5/02 ,  A61K8/60 ,  A61K47/26 ,  A61K47/36 ,  A61K31/732 ,  B01F3/22 ,  A61K9/14

Abstract: Provided is a method of producing a solid dispersion that can improve solubility of a hardly soluble polyphenol in water. Specifically, provided is a method of producing a solid dispersion containing an amorphous hardly soluble polyphenol, the method including the steps of: mixing (A) a hardly soluble polyphenol, (B) at least one selected from the group consisting of a plant-derived polysaccharide, a seaweed-derived polysaccharide, and a microorganism-derived polysaccharide, a plant-derived polypeptide, and a microorganism-derived polypeptide, and (C) at least one selected from the group consisting of a monosaccharide and a disaccharide, followed by melting of the mixture by heating; and solidifying the molten product by cooling.

公开(公告)号：US09822091B2

公开(公告)日：2017-11-21

申请号：US14904014

申请日：2014-06-13

Applicant: KAO CORPORATION

Inventor： Yasushi Yamada ,  Tetsuya Abe ,  Akihiro Uda ,  Masanori Matsuura

IPC: C07D311/78 ,  A61K31/366 ,  A23L33/105 ,  A23L2/52

CPC classification number: C07D311/78 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/366 ,  A23V2250/2132

Abstract: Provided is a production method for an ellagic acid composition excellent in solubility in water. The production method for an ellagic acid composition includes the steps of: mixing an aqueous medium with a raw material which contains a guava leaf extract and which contains, in solids thereof, 1 to 5% by mass of free ellagic acid to prepare a material for heat treatment; and subjecting the material for heat treatment to heat treatment at from 100 to 180° C.