公开(公告)号：US11419797B2

公开(公告)日：2022-08-23

申请号：US16958331

申请日：2018-12-27

Applicant: KAO CORPORATION

Inventor： Takashi Suzuki ,  Tetsuya Abe ,  Rui Takahashi ,  Koji Endo ,  Toyoki Hagura ,  Hidetaka Iwai ,  Teruo Horizumi ,  Taisuke Aosaki ,  Akihiro Uda ,  Masato Nakamichi

IPC: A61K8/04 ,  A61K8/34 ,  A61K8/37 ,  A61Q19/00

Abstract: Methods for producing a composition containing a hardly water-soluble aromatic compound are described which involve Step (1), including Step (1-1) for preparing a material comprising: (A) a hardly water-soluble aromatic compound, (B) a polyol, and (C) an aqueous medium, where a content of the (A) hardly water-soluble aromatic compound in the material for heating is below a saturation solubility of the (A) hardly water-soluble aromatic compound in a solvent having the same composition at 25° C. The obtained solution is then heated in Step (1-2) at normal pressure at a temperature of less than 100° C., to obtain a hardly water-soluble aromatic compound solution 1. Step (2) includes adding water to the hardly water-soluble aromatic compound solution 1 such that the resulting hardly water-soluble aromatic compound solution 2 has a concentration of the (A) hardly water-soluble aromatic compound above a saturation solubility at 25° C.

公开(公告)号：US11642288B2

公开(公告)日：2023-05-09

申请号：US17633499

申请日：2021-02-05

Applicant: KAO CORPORATION

Inventor： Naomi Amari ,  Takuji Kume ,  Makoto Onoo ,  Takehiko Tojo ,  Rui Takahashi

IPC: A61K8/04 ,  A61K8/73 ,  A61K8/81 ,  A61Q19/00 ,  A61K8/02 ,  A61K8/49 ,  A61K8/63 ,  A61K8/68 ,  A61K9/00 ,  A61K47/32 ,  A61K47/36

CPC classification number: A61K8/027 ,  A61K8/04 ,  A61K8/498 ,  A61K8/63 ,  A61K8/68 ,  A61K8/73 ,  A61K8/8129 ,  A61K8/8176 ,  A61K9/0014 ,  A61K47/32 ,  A61K47/36

Abstract: Provided is a liquid skin external composition which allows a poorly water-soluble component to be applied to a skin in a liquid state.
An assembly of fiber for use in production of a liquid skin external composition, the assembly of fiber comprising (a) a polymer soluble in water and an alcohol or a ketone in a content of 50 mass % or more and 98 mass % or less with respect to the whole assembly of fiber and (b) a poorly water-soluble component in a content of 2 mass % or more and 40 mass % or less with respect to the whole assembly of fiber.