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公开(公告)号：US20180355297A1
公开(公告)日：2018-12-13
申请号：US16066724
申请日：2017-01-03
Inventor： Jürgen KOSEL , Mincho Nikolaev KAVALDZHIEV , Jose Efrain PEREZ
CPC classification number: C12M1/26 , A61B5/685 , A61B10/0045 , A61B10/0233 , A61B2010/0225 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B81B1/008 , B81B2201/055 , B81C1/00111 , B82Y5/00 , C12M23/20
Abstract: Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.
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公开(公告)号：US20210123039A1
公开(公告)日：2021-04-29
申请号：US17041761
申请日：2019-04-02
Inventor： Jürgen KOSEL , Jose Efrain PEREZ , Jasmeen Sayed MERZABAN
Abstract: Differentiation of a stem cell involves arranging the stem cell on a scaffold having an ordered array of magnetic one-dimensional nanostructures and culturing the stem cell while applying a magnetic field having a frequency to the ordered array of magnetic one-dimensional nanostructures to differentiate the stem cell.
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