公开(公告)号：US20220369684A1

公开(公告)日：2022-11-24

申请号：US17767181

申请日：2020-10-08

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： So Young LEE ,  Seung Yong KIM ,  Young Do NAM ,  So Lim PARK ,  Dong Uk SHIN ,  Hee Soon SHIN ,  Jin Eun EOM ,  Sun Young JUNG ,  Dae Woon CHOI

IPC: A23L33/135 ,  A61K35/747 ,  A61P11/00

Abstract: The present invention relates to a food composition for enhancing respiratory function and improving respiratory diseases, using Lactobacillus plantarum KF511 strain; a health functional food comprising the food composition; and a pharmaceutical composition for preventing or treating the respiratory diseases, comprising Lactobacillus plantarum strain, its culture solution, its concentrate, or its dried product, as an active ingredient.
The Lactobacillus plantarum KF511 strain, according to the present invention shows activities of inhibiting secretion of MUC5AC in a mucus hypersecretion model using a respiratory epithelial cell (H292) of a human, inhibiting Netosis activation of neutrophil extracellular traps, inhibiting expression of inflammatory cytokines by Cigarette Smoke Extraction (CSE) of NCI-H292 cells that are a bronchial epithelial cell line, and furthermore, inhibiting damage of a lung tissue in a mouse model of a respiratory disease induced by the CSE and PPE, inhibiting infiltration of immune cells such as total cells, macrophages, lymphocytes, eosinophils, and neutrophils in BALF, and inhibiting secretion of inflammatory cytokines and chemokines in the BALF and the lung tissue.