公开(公告)号：US20220369684A1

公开(公告)日：2022-11-24

申请号：US17767181

申请日：2020-10-08

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： So Young LEE ,  Seung Yong KIM ,  Young Do NAM ,  So Lim PARK ,  Dong Uk SHIN ,  Hee Soon SHIN ,  Jin Eun EOM ,  Sun Young JUNG ,  Dae Woon CHOI

IPC: A23L33/135 ,  A61K35/747 ,  A61P11/00

Abstract: The present invention relates to a food composition for enhancing respiratory function and improving respiratory diseases, using Lactobacillus plantarum KF511 strain; a health functional food comprising the food composition; and a pharmaceutical composition for preventing or treating the respiratory diseases, comprising Lactobacillus plantarum strain, its culture solution, its concentrate, or its dried product, as an active ingredient.
The Lactobacillus plantarum KF511 strain, according to the present invention shows activities of inhibiting secretion of MUC5AC in a mucus hypersecretion model using a respiratory epithelial cell (H292) of a human, inhibiting Netosis activation of neutrophil extracellular traps, inhibiting expression of inflammatory cytokines by Cigarette Smoke Extraction (CSE) of NCI-H292 cells that are a bronchial epithelial cell line, and furthermore, inhibiting damage of a lung tissue in a mouse model of a respiratory disease induced by the CSE and PPE, inhibiting infiltration of immune cells such as total cells, macrophages, lymphocytes, eosinophils, and neutrophils in BALF, and inhibiting secretion of inflammatory cytokines and chemokines in the BALF and the lung tissue.

公开(公告)号：US20220339218A1

公开(公告)日：2022-10-27

申请号：US17714361

申请日：2022-04-06

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do NAM ,  Yun-Tai KIM ,  Hee Soon SHIN ,  So-Young LEE ,  Jae-Goo KIM ,  Eun-Yeong LIM ,  Eun-Ji SONG

IPC: A61K35/747 ,  A23L33/135 ,  A61P5/24 ,  C12N1/20

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US20220154250A1

公开(公告)日：2022-05-19

申请号：US17278472

申请日：2019-05-29

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-do NAM ,  Won-Hyong CHUNG ,  Mi Young LIM ,  So-Young LEE ,  Yong-Soo PARK ,  Jisu KANG ,  Yun-Tai KIM ,  Hee Soon SHIN ,  Ji-hee SHIN ,  Seungpyo Hong

IPC: C12Q1/689

Abstract: The present disclosure relates to a composition for discriminating the species Lactobacillus acidophilus, which enables microorganisms belonging to the species Lactobacillus acidophilus to be discriminated, detected and identified simply, quickly and accurately from a target sample. Therefore, the present disclosure can be effectively used in the development of fermented milk, baby food, dairy products, livestock feed, cosmetics, health supplements, drugs for intestinal disorders, raw materials, etc. using the Lactobacillus acidophilus sp. strain.

公开(公告)号：US20210338748A1

公开(公告)日：2021-11-04

申请号：US16324928

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do NAM ,  Yun-Tai KIM ,  Hee Soon SHIN ,  So-Young LEE ,  Jae-Goo KIM ,  Eun-Yeong LIM ,  Eun-Ji SONG

IPC: A61K35/747 ,  A23L33/135 ,  A61K8/99 ,  A61P5/24 ,  C12N1/20

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US20190192591A1

公开(公告)日：2019-06-27

申请号：US16325018

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do NAM ,  Yun-Tai KIM ,  Hee Soon SHIN ,  So-Young LEE ,  Jae-Goo KIM ,  Eun-Yeong LIM ,  Eun-Ji SONG

IPC: A61K35/747 ,  A23L33/135 ,  A61Q19/00 ,  C12N1/20 ,  A61K8/99 ,  C12R1/23 ,  A61P15/00

CPC classification number: A61K35/747 ,  A23L33/135 ,  A61K8/99 ,  A61P15/00 ,  A61Q19/00 ,  A61Q19/08 ,  C12N1/20 ,  C12R1/23

Abstract: Provided is a novel Lactobacillus acidophilus YTI strain (deposition number: KCCM 11808P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus acidophilus comprising the novel strain.