公开(公告)号：US11324785B2

公开(公告)日：2022-05-10

申请号：US16324928

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  A61K35/00 ,  A23L33/135 ,  A61P5/24 ,  C12N1/20 ,  C12R1/225

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US12016890B2

公开(公告)日：2024-06-25

申请号：US17714361

申请日：2022-04-06

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  A23L33/135 ,  A61K35/00 ,  C12R1/225

CPC classification number: A61K35/747 ,  A23L33/135 ,  A61K2035/115 ,  C12R2001/225

Abstract: The present invention relates to: a novel Lactobacillus intestinalis YT2 strain (deposition number: KCCM11812P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus intestinalis comprising the novel strain. The present inventors have established an animal model for menopause through ovariectomy, confirmed changes of the distribution of intestinal microorganisms by the model, identified and isolated a novel Lactobacillus intestinalis strain among lactic acid bacteria of which the distribution is significantly reduced in the menopausal model, and confirmed effects, by means of the novel strain and previously reported Lactobacillus intestinalis strains, of alleviating menopausal symptoms, such as the inhibition of an increase in body fat, the inhibition of a decrease in bone mineral density, the inhibition of an increase in the pain sensitivity, and the alleviation of depression. Therefore, it is expected that the composition comprising the Lactobacillus intestinalis according to the present invention can be usable for a use of preventing, alleviating, or treating menopause.

公开(公告)号：US11260087B2

公开(公告)日：2022-03-01

申请号：US16325018

申请日：2017-08-11

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young-Do Nam ,  Yun-Tai Kim ,  Hee Soon Shin ,  So-Young Lee ,  Jae-Goo Kim ,  Eun-Yeong Lim ,  Eun-Ji Song

IPC: A61K35/747 ,  C12N1/20 ,  A23L33/135 ,  A61Q19/08 ,  A61P15/00 ,  A61K8/99 ,  A61Q19/00 ,  C12R1/23

Abstract: Provided is a novel Lactobacillus acidophilus YTI strain (deposition number: KCCM 11808P); and a composition for preventing, alleviating, or treating menopause, comprising, as an active ingredient, Lactobacillus acidophilus comprising the novel strain.