公开(公告)号：US11564955B2

公开(公告)日：2023-01-31

申请号：US16462901

申请日：2017-11-21

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Myung Ki Lee ,  Sang Dong Lim ,  Sung Hun Yi ,  Yong Sun Cho ,  Young Do Nam ,  Jin Ju Bae

IPC: A61K35/744 ,  A23L33/135

Abstract: The present invention relates to a composition comprising as an active ingredient a strain having excellent ability to produce formic acid for preventing or treating obesity or metabolic syndromes caused by obesity; and to a food composition and a health functional food each comprising the active ingredient. The strain having excellent ability to produce formic acid according to the present invention not only has effects of reducing body weight and inhibiting fat accumulation in organs, but also has activity to effectively lower blood triglyceride and cholesterol levels, and therefore, the composition comprising the strain as an active ingredient can be favorably used as a composition capable of preventing/alleviating or treating obesity or metabolic syndromes caused by obesity. Therefore, the strain having excellent ability to produce formic acid according to the present invention can be favorably used as a material for a medical product or health food.

公开(公告)号：US11278579B2

公开(公告)日：2022-03-22

申请号：US16903955

申请日：2020-06-17

Applicant: KOREA FOOD RESEARCH INSTITUTE

Inventor： Young Do Nam ,  So Young Lee ,  Hee Soon Shin ,  So Lim Park ,  Won Hyong Chung ,  Eun Sook Lee ,  Eun Ji Song ,  Dong Uk Shin

IPC: A61K35/747 ,  A61K39/09 ,  A61K35/00 ,  A61K35/742 ,  C12R1/225

Abstract: A novel Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.