公开(公告)号：US20240255523A1

公开(公告)日：2024-08-01

申请号：US18290436

申请日：2022-05-03

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sun-Woong KANG ,  Hye Eun SHIM ,  Byoung-Seok LEE ,  Ji Sek HAN ,  Sumi JANG

IPC: G01N33/68 ,  G01N33/50

CPC classification number: G01N33/6887 ,  G01N33/5005 ,  G01N2333/78

Abstract: The present invention relates to a method for producing a cartilage model, comprising the step of simultaneously culturing a porous natural polymer support and a cartilage cell; a cartilage model produced by the method; and a method for testing the activity or toxicity of a test substance, comprising the step of treating the cartilage model with the test substance. A mature cartilage or aged cartilage model that can substitute an animal model may be produced using the method for producing the cartilage model according to the present invention, and the effectiveness and safety of the test substance may be accurately verified using the cartilage model thus produced, and thus, the cartilage model may be diversely utilized in the fields of new medicine development, disease research, and artificial organ development.

公开(公告)号：US20170275586A1

公开(公告)日：2017-09-28

申请号：US15504062

申请日：2015-07-30

Applicant: THE INDUSTRY & ACADEMIC COOPERTATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kang Moo HUH ,  Sun Woong KANG ,  Han Chang KANG ,  Hye Eun SHIM ,  Ik Sung CHO ,  Myeong Ok CHO

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  C12M23/10 ,  C12M23/20 ,  C12N2533/72

Abstract: Disclosed is a spheroid forming culture container using a temperature-sensitive glycol chitosan derivative and a spheroid forming method using the same. In the disclosed spheroid forming culture container, a surface of a culturing space is coated with a glycol chitosan derivative having reversible sol-gel transition characteristic depending on temperature.