公开(公告)号：US20220160747A1

公开(公告)日：2022-05-26

申请号：US17440877

申请日：2020-03-20

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Seong Jun PARK ,  Chang Hoon LEE ,  Hwan Jung LIM

IPC: A61K31/7076 ,  A61K31/52 ,  A61P35/00

Abstract: The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of cancer comprising a novel azolopyrimidine heterocyclic compound as an active ingredient, and the pharmaceutical composition for the prophylaxis or treatment of cancer of the present invention can be used as a small molecular immunotherapy anticancer agent which modulates an adenosine pathway by comprising the azolopyrimidine heterocyclic compound.

公开(公告)号：US20180186744A1

公开(公告)日：2018-07-05

申请号：US15909088

申请日：2018-03-01

Applicant: NATIONAL CANCER CENTER ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyung Chae JEONG ,  Hwan Jung LIM ,  Seong Jun PARK ,  Ho Kyung SEO ,  Kyung Ohk AHN ,  Sang Jin LEE ,  Eun Sook LEE

IPC: C07D215/36 ,  C07D519/00 ,  C07D413/12 ,  C07D409/12 ,  C07D215/233 ,  C07D401/14 ,  C07D401/12 ,  C07D215/58 ,  C07D405/12

CPC classification number: C07D215/36 ,  C07D215/233 ,  C07D215/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are novel compounds of specific chemical structures having inhibitory activity on c-Myc/Max/DNA complex formation or pharmaceutically acceptable salts thereof.

公开(公告)号：US20220017491A1

公开(公告)日：2022-01-20

申请号：US17292699

申请日：2019-11-08

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hwan Jung LIM ,  Seong Jun PARK ,  Chang Hoon LEE ,  Kyoung Tai NO ,  Jiwon CHOI ,  Hei-Cheul JEUNG ,  You-keun SHIN ,  Jong Wan KIM ,  Xuemei JIN

IPC: C07D401/14 ,  C07D401/12 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to a compound which inhibits the binding of Yes associated protein (YAP) and transcriptional enhancer associate domain (TEAD), a prodrug of same, a hydrate of same, a solvate of same or a pharmaceutically acceptable salt of same, and a composition comprising same as an active ingredient, the compound according to the present invention being able to be applied as an inhibitor which can directly inhibit YAP-TEAD binding in the Hippo pathway which plays a crucial role in the occurrence of cancer.

公开(公告)号：US20210315879A1

公开(公告)日：2021-10-14

申请号：US16321631

申请日：2017-07-27

Applicant: NATIONAL CANCER CENTER ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyung Chae JEONG ,  Hwan Jung LIM ,  Seong Jun PARK ,  Ho Kyung SEO ,  Kyung Ohk AHN ,  Sang Jin LEE ,  Eun Sook LEE

IPC: A61K31/47 ,  A61K31/4709 ,  A61P35/00

Abstract: Provided is a method for treating or preventing cancer, containing, as an active ingredient, a compound having a specific chemical structure and an activity of inhibiting the formation of a c-Myc/Max/DNA complex, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180029988A1

公开(公告)日：2018-02-01

申请号：US15663179

申请日：2017-07-28

Applicant: NATIONAL CANCER CENTER ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Kyung Chae JEONG ,  Hwan Jung LIM ,  Seong Jun PARK ,  Ho Kyung SEO ,  Kyung Ohk AHN ,  Sang Jin LEE ,  Eun Sook LEE

IPC: C07D215/36 ,  C07D413/12 ,  C07D519/00 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D215/58 ,  C07D405/12

CPC classification number: C07D215/36 ,  C07D215/233 ,  C07D215/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are novel compounds of specific chemical structures having inhibitory activity on c-Myc/Max/DNA complex formation or pharmaceutically acceptable salts thereof.