公开(公告)号：US20250064719A1

公开(公告)日：2025-02-27

申请号：US18939509

申请日：2024-11-06

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Sung Hoi HONG ,  In Sik HWANG

IPC: A61K8/98 ,  A61K8/02 ,  A61K8/04 ,  A61K8/64 ,  A61K8/66 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10

Abstract: The present invention relates to a method of preparing a culture broth of neural stem cells, having excellent abilities of reducing skin wrinkles or increasing skin elasticity, the culture broth comprising high concentrations of TIMP-1 and TIMP-2 capable of inhibiting the expression and activity of matrix metalloproteinases (MMPs) involved in collagen decomposition in the dermis. The culture broth of neural stem cells according to the present invention, which comprises, as active ingredients, high concentrations of TIMP-1 and TIMP-2 and low concentrations of various MMPs, restores the synthesis of collagen and elastin by suppressing the expression and activity of MMPs inhibiting collagen formation, and thus is useful as a composition for reducing skin wrinkles or increasing skin elasticity.

公开(公告)号：US20210244652A1

公开(公告)日：2021-08-12

申请号：US16972792

申请日：2019-05-31

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Sung Hoi HONG ,  In Sik HWANG

IPC: A61K8/98 ,  A61K8/02 ,  A61K8/66 ,  A61Q1/12 ,  A61K8/04 ,  A61Q19/08 ,  A61Q19/10 ,  A61K8/64 ,  A61Q19/00

Abstract: The present invention relates to a method of preparing a culture broth of neural stem cells, having excellent abilities of reducing skin wrinkles or increasing skin elasticity, the culture broth comprising high concentrations of TIMP-1 and TIMP-2 capable of inhibiting the expression and activity of matrix metalloproteinases (MMPs) involved in collagen decomposition in the dermis. The culture broth of neural stem cells according to the present invention, which comprises, as active ingredients, high concentrations of TIMP-1 and TIMP-2 and low concentrations of various MMPs, restores the synthesis of collagen and elastin by suppressing the expression and activity of MMPs inhibiting collagen formation, and thus is useful as a composition for reducing skin wrinkles or increasing skin elasticity.