公开(公告)号：US20190010045A1

公开(公告)日：2019-01-10

申请号：US16028990

申请日：2018-07-06

Applicant: Kevin Whaley

Inventor： Kevin Whaley

IPC: B67D3/00

Abstract: A novel fluid dispenser system is described. The system is comprised of a plurality of connectors that each connect to one a plurality of fluid supply containers and, once connected, hold a valve on the supply container in an opened position. The connectors are connected, using flexible tubing, to a valve manifold that selectively dispenses fluid from each of the supply containers. The system provides a means of selectively and safely delivering fluid from large and ungainly supply containers without the need for lifting or otherwise manipulating the supply container itself. The system is especially useful in delivering laundry detergent and other additives from supply containers to a washing machine in a home use application.

公开(公告)号：US20160326234A1

公开(公告)日：2016-11-10

申请号：US15146990

申请日：2016-05-05

Applicant: Andrew Hiatt ,  Larry Zeitlin ,  Kevin Whaley ,  Michael Pauly

Inventor： Andrew Hiatt ,  Larry Zeitlin ,  Kevin Whaley ,  Michael Pauly

IPC: C07K16/10

CPC classification number: C07K16/10 ,  A61K2039/507 ,  C07K2317/13 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/8258

Abstract: Antibody variants originating from the monoclonal antibody 13C6, and wherein the N-glycosylation site within the constant region of the heavy chain contains a glycan that is either wild-type or largely devoid of fucose residues, will bind Ebola virus glycoprotein and provide surprising efficacy in treating animals or humans infected with Ebola virus when used in combination with one or more additional anti-Ebola mAbs. Such antibody cocktails are vastly superior to other known monoclonal antibodies or monoclonal antibody combinations in treating animals and humans infected with the Ebola virus.

公开(公告)号：US10233071B2

公开(公告)日：2019-03-19

申请号：US16028990

申请日：2018-07-06

Applicant: Kevin Whaley

Inventor： Kevin Whaley

IPC: B67D3/00 ,  B05C7/08 ,  B67D3/02

Abstract: A novel fluid dispenser system is described. The system is comprised of a plurality of connectors that each connect to one a plurality of fluid supply containers and, once connected, hold a valve on the supply container in an opened position. The connectors are connected, using flexible tubing, to a valve manifold that selectively dispenses fluid from each of the supply containers. The system provides a means of selectively and safely delivering fluid from large and ungainly supply containers without the need for lifting or otherwise manipulating the supply container itself. The system is especially useful in delivering laundry detergent and other additives from supply containers to a washing machine in a home use application.

公开(公告)号：US20160324965A1

公开(公告)日：2016-11-10

申请号：US14706910

申请日：2015-05-07

Applicant: Andrew Hiatt ,  Larry Zeitlin ,  Kevin Whaley ,  Michael Pauly

Inventor： Andrew Hiatt ,  Larry Zeitlin ,  Kevin Whaley ,  Michael Pauly

IPC: A61K39/42

CPC classification number: A61K39/42 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/10 ,  C07K2317/24 ,  C07K2317/76

Abstract: Antibody variants originating from the monoclonal antibody 13C6, and wherein the N-glycosylation site within the constant region of the heavy chain contains a glycan that is either wild-type or largely devoid of fucose residues, will bind Ebola virus glycoprotein and provide surprising efficacy in treating animals or humans infected with Ebola virus when used in combination with one or more additional anti-Ebola mAbs. Such antibody cocktails are vastly superior to other known monoclonal antibodies or monoclonal antibody combinations in treating animals and humans infected with the Ebola virus.

Abstract translation: 来源于单克隆抗体13C6的抗体变体，并且其中重链恒定区内的N-糖基化位点含有野生型或大量缺乏岩藻糖残基的聚糖，将结合埃博拉病毒糖蛋白并提供惊人的功效 当与一种或多种另外的抗 - 埃博拉病毒mAb组合使用时，治疗被埃博拉病毒感染的动物或人。 这样的抗体混合物在治疗感染埃博拉病毒的动物和人类方面与其它已知的单克隆抗体或单克隆抗体组合相比非常优越。