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    Optical sensor and optical method for characterizing a chemical or biological substance
    1.
    发明授权
    Optical sensor and optical method for characterizing a chemical or biological substance 有权
    用于表征化学或生物物质的光学传感器和光学方法

    公开(公告)号：US06455004B1

    公开(公告)日：2002-09-24

    申请号：US09508384

    申请日：2000-06-19

    Applicant: Kurt Tiefenthaler

    Inventor： Kurt Tiefenthaler

    IPC: G01N1700

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7743 ,  Y10S436/805 ,  Y10T436/11

    Abstract: The optical sensor contains an optical waveguide (1) with a substrate (104), waveguiding material (105), a cover medium (106) and a waveguide grating structure (101-103). By means of a light source (2), light can be emitted to the waveguide grating structure (101-103) from the substrate side and/or from the cover medium side (101-103). With means of detection (11), at least two differing light proportions (7-10) radiated from the waveguide (1) can be detected. For carrying out a measurement, the waveguide can be immovably fixed relative to the light source (2) and the means of detection (11). The waveguide grating structure (101-103) itself consists of one or several waveguide grating structure units (101-103), which if so required can be equipped with (bio-)chemo-sensitive layers. The sensor permits the generation of absolute measuring signals.

    Abstract translation: 光学传感器包括具有基底（104），波导材料（105），覆盖介质（106）和波导光栅结构（101-103）的光波导（1）。 借助于光源（2），可以从衬底侧和/或从封盖介质侧（101-103）向光波导光栅结构（101-103）发射光。 利用检测装置（11），可以检测从波导（1）辐射的至少两个不同的光比（7-10）。 为了进行测量，波导可以相对于光源（2）和检测装置（11）不可移动地固定。 波导光栅结构（101-103）本身由一个或多个波导光栅结构单元（101-103）组成，如果需要，可以配备（生物）化学敏感层。 传感器允许产生绝对测量信号。

    Detection method
    2.
    发明授权
    Detection method 有权
    检测方法

    公开(公告)号：US06818886B2

    公开(公告)日：2004-11-16

    申请号：US10344186

    申请日：2003-02-07

    Applicant: Kurt Tiefenthaler

    Inventor： Kurt Tiefenthaler

    IPC: H01J4900

    CPC classification number: H01J49/164 ,  G01N21/552 ,  G01N21/7746

    Abstract: A method for detecting a substance or substances in a sample or in a matrix of samples combining detection methods that are, on the one hand, based on direct detection with integrated optical (bio)chemo-sensitive waveguide grating structures and, on the other hand, based on a mass-spectrometric detection effected by way of a desorption process. The method permits an increase in detection security and/or detection sensitivity.

    Abstract translation: 一种用于检测样品或样品的基质中的物质的方法，其结合了一方面基于直接检测与集成的光学（生物）化学敏感波导光栅结构的检测方法，另一方面 ，基于通过解吸过程实现的质谱检测。 该方法允许增加检测安全性和/或检测灵敏度。

    Optical sensor for selective detection of substances and/or for the detection of refractive index changes in gaseous, liquid, solid and porous samples
    3.
    发明授权
    Optical sensor for selective detection of substances and/or for the detection of refractive index changes in gaseous, liquid, solid and porous samples 失效
    用于选择性检测物质和/或用于检测气体，液体，固体和多孔样品中的折射率变化的光学传感器

    公开(公告)号：US4815843A

    公开(公告)日：1989-03-28

    申请号：US019557

    申请日：1987-01-27

    Applicant: Kurt Tiefenthaler ,  Walter Lukosz

    Inventor： Kurt Tiefenthaler ,  Walter Lukosz

    IPC: G01N21/41 ,  G01N21/43 ,  G01N21/75 ,  G01N21/77 ,  G01N33/53 ,  G01N33/543 ,  G02B6/12 ,  G02B6/124 ,  G02B6/34

    CPC classification number: G01N21/7743 ,  G01N21/431 ,  G02B6/12007 ,  G02B6/124 ,  G01N2021/437 ,  G02B6/34

    Abstract: The optical sensor for the detection of specific substances and refractive index changes in gaseous, liquid, solid and porous samples is composed of integrated optical elements. It consists of a waveguiding film (1) equipped with a diffraction grating (4) and applied onto a substrate (2). For the selective detection of a specific substance contained in the sample (3) a selectively chemisorbing additional layer (5) covers the film (1) at least in the grating region. The sample (3) is applied at least in the grating region either directly onto the waveguiding film (1) or onto the selectively chemisorbing additional layer (5). Chemisorption of the substance, which is contained in the sample (3) and is to be detected, to the selectively chemisorbing additional layer (5) results in a further adlayer (6) coating the waveguiding film (1). The principle of the sensor is as follows: Due to chemisorption of a further adlayer (6) and/or due to a refractive index change of the sample (3) a change in the effective refractive index N of a mode guided in the waveguiding film (1) is effected. For the detection of this change the set-up (1,2,3,4,5) described above is used as grating coupler or Bragg reflector.

    Abstract translation: PCT No.PCT / CH86 / 00072 Sec。 371日期1987年1月27日第 102（e）日期1987年1月27日PCT提交1986年5月29日PCT公布。 公开号WO86 / 07149 日期为1986年12月4日。用于检测气体，液体，固体和多孔样品中特定物质和折射率变化的光学传感器由集成光学元件组成。 它包括配备有衍射光栅（4）并施加到基板（2）上的波导膜（1）。 为了选择性地检测样品（3）中包含的特定物质，选择性化学吸附附加层（5）至少在光栅区域中覆盖膜（1）。 样品（3）至少在光栅区域直接施加到波导膜（1）上或选择性化学吸附附加层（5）上。 将样品（3）中包含并且待检测的物质的化学吸附作用到选择性化学吸附附加层（5），导致涂覆波导膜（1）的另外的涂层（6）。 传感器的原理如下：由于另外的吸收层（6）的化学吸附和/或由于样品（3）的折射率变化引起的波导膜中引导的模式的有效折射率N的变化 （1）。 为了检测这种变化，上述设置（1,2,3,4,5）用作光栅耦合器或布拉格反射器。

    Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance
    5.
    发明授权
    Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance 有权
    用于表征化学和/或生物化学物质的光学传感器和光学过程

    公开(公告)号：US07867448B2

    公开(公告)日：2011-01-11

    申请号：US10908945

    申请日：2005-06-01

    Applicant: Kurt Tiefenthaler

    Inventor： Kurt Tiefenthaler

    IPC: G01N21/00 ,  G02B6/00 ,  G02B6/26 ,  G02B6/10

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7743 ,  Y10S436/805 ,  Y10T436/11

    Abstract: The optical sensor contains an optical waveguide (1) with a substrate (104), waveguiding material (105), a cover medium (106) and a waveguide grating structure (101-103). By means of a light source (2), light can be emitted to the waveguide grating structure (101-103) from the substrate side and/or from the cover medium side. (101-103). With means of detection (11), at least two differing light proportions (7-10) radiated from the waveguide (1) can be detected. For carrying out a measurement, the waveguide can be immovably fixed relative to the light source (2) and the means of detection (11). The waveguide grating structure (101-103) itself consists of one or several waveguide grating structure units (101-103), which if so required can be equipped with (bio-)chemo-sensitive layers. The sensor permits the generation of absolute measuring signals.

    Abstract translation: 光学传感器包括具有基底（104），波导材料（105），覆盖介质（106）和波导光栅结构（101-103）的光波导（1）。 通过光源（2），可以从衬底侧和/或从覆盖介质侧将光发射到波导光栅结构（101-103）。 （101-103）。 利用检测装置（11），可以检测从波导（1）辐射的至少两个不同的光比（7-10）。 为了进行测量，波导可以相对于光源（2）和检测装置（11）不可移动地固定。 波导光栅结构（101-103）本身由一个或多个波导光栅结构单元（101-103）组成，如果需要，可以配备（生物）化学敏感层。 传感器允许产生绝对测量信号。

    Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance
    8.
    发明授权
    Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance 有权
    用于表征化学和/或生物化学物质的光学传感器和光学过程

    公开(公告)号：US06958131B2

    公开(公告)日：2005-10-25

    申请号：US10710609

    申请日：2004-07-23

    Applicant: Kurt Tiefenthaler

    Inventor： Kurt Tiefenthaler

    IPC: G01N21/552 ,  G01N21/77 ,  G01N17/00 ,  G01N7/00 ,  G01N21/01 ,  G01N21/47 ,  G01N21/75

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7743 ,  Y10S436/805 ,  Y10T436/11

    Abstract: The optical sensor contains an optical waveguide (1) with a substrate (104), waveguiding material (105), a cover medium (106) and a waveguide grating structure (101-103). By means of a light source (2), light can be emitted to the waveguide grating structure (101-103) from the substrate side and/or from the cover medium side. (101-103). With means of detection (11), at least two differing light proportions (7-10) radiated from the waveguide (1) can be detected. For carrying out a measurement, the waveguide can be immovably fixed relative to the light source (2) and the means of detection (11). The waveguide grating structure (101-103) itself consists of one or several waveguide grating structure units (101-103), which if so required can be equipped with (bio-)chemo-sensitive layers. The sensor permits the generation of absolute measuring signals.

    Abstract translation: 光学传感器包括具有基底（104），波导材料（105），覆盖介质（106）和波导光栅结构（101-103）的光波导（1）。 通过光源（2），可以从衬底侧和/或从覆盖介质侧将光发射到波导光栅结构（101-103）。 （101-103）。 利用检测装置（11），可以检测从波导（1）辐射的至少两个不同的光比（7-10）。 为了进行测量，波导可以相对于光源（2）和检测装置（11）不可移动地固定。 波导光栅结构（101-103）本身由一个或多个波导光栅结构单元（101-103）组成，如果需要，可以配备（生物）化学敏感层。 传感器允许产生绝对测量信号。

    Optical Sensor and optical process for the characterization of a chemical and/or bio-chemical substance
    10.
    发明申请
    Optical Sensor and optical process for the characterization of a chemical and/or bio-chemical substance 有权
    用于表征化学和/或生物化学物质的光学传感器和光学过程

    公开(公告)号：US20050201657A1

    公开(公告)日：2005-09-15

    申请号：US10908945

    申请日：2005-06-01

    Applicant: Kurt Tiefenthaler

    Inventor： Kurt Tiefenthaler

    IPC: G01N21/552 ,  G01N21/77 ,  G02B6/00

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7743 ,  Y10S436/805 ,  Y10T436/11

    Abstract: The optical sensor contains an optical waveguide (1) with a substrate (104), waveguiding material (105), a cover medium (106) and a waveguide grating structure (101-103). By means of a light source (2), light can be emitted to the waveguide grating structure (101-103) from the substrate side and/or from the cover medium side. (101-103). With means of detection (11), at least two differing light proportions (7-10) radiated from the waveguide (1) can be detected. For carrying out a measurement, the waveguide can be immovably fixed relative to the light source (2) and the means of detection (11). The waveguide grating structure (101-103) itself consists of one or several waveguide grating structure units (101-103), which if so required can be equipped with (bio-)chemo-sensitive layers. The sensor permits the generation of absolute measuring signals.

    Abstract translation: 该光学传感器包括具有衬底（104），波导材料（105），覆盖介质（106）和波导光栅结构（101-103）的光波导（1）。 借助于光源（2），可以从衬底侧和/或从覆盖介质侧将光发射到波导光栅结构（101-103）。 （101-103）。 利用检测装置（11），可以检测从波导（1）辐射的至少两个不同的光比（7-10）。 为了进行测量，波导可以相对于光源（2）和检测装置（11）不可移动地固定。 波导光栅结构（101 - 103）本身由一个或多个波导光栅结构单元（101 - 103）组成，如果需要，可以配备（生物）化学敏感层。 传感器允许产生绝对测量信号。

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