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    METHOD AND APPARATUS FOR PREPARING NOVEL LIPOSOME
    2.
    发明申请
    METHOD AND APPARATUS FOR PREPARING NOVEL LIPOSOME 有权
    制备新型脂质体的方法和装置

    公开(公告)号：US20130069261A1

    公开(公告)日：2013-03-21

    申请号：US13580236

    申请日：2011-02-24

    Applicant: Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    Inventor： Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    IPC: A61J3/07

    CPC classification number: A61J3/07 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/19 ,  A61K31/70 ,  B01D11/0411

    Abstract: Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.

    Abstract translation: 公开了一种制备脂质体制剂的方法。 在所公开的方法中，将脂质部分溶解在有机溶剂中。 将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。 通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。 优选地，制剂可以包括一种或多种生物活性成分。 根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。 该制备方法可以在实验室规模下轻松进行。 此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

    Method and apparatus for preparing novel liposome
    5.
    发明授权
    Method and apparatus for preparing novel liposome 有权
    制备新型脂质体的方法和装置

    公开(公告)号：US09579261B2

    公开(公告)日：2017-02-28

    申请号：US13580236

    申请日：2011-02-24

    Applicant: Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    Inventor： Sung Joo Hwang ,  Hee Jun Park ,  Wonkyung Cho ,  Kwang-Ho Cha ,  Junsung Park ,  Chanhyuk Park ,  Donggeon Gu

    IPC: A61J3/07 ,  A61K9/127 ,  A61K9/19 ,  A61K31/70 ,  B01D11/04

    CPC classification number: A61J3/07 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/19 ,  A61K31/70 ,  B01D11/0411

    Abstract: Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.

    Abstract translation: 公开了一种制备脂质体制剂的方法。 在所公开的方法中，将脂质部分溶解在有机溶剂中。 将包含生物活性成分和脂质部分的溶液与载体一起放入反应容器中，并向其中引入超临界流体，以制备涂覆有生物活性成分 - 脂质的颗粒。 通过压缩将超临界流体排出以获得催乳素体颗粒，然后通过包含水的水溶液使前体脂质颗粒水合以形成脂质体溶液。 优选地，制剂可以包括一种或多种生物活性成分。 根据需要，脂质体制剂可以通过诸如粒径减小，去除有机溶剂和冷冻干燥的方法进一步加工。 该制备方法可以在实验室规模下轻松进行。 此外，相同的方法可以在批量生产或商业规模的脂质体制剂制备中使用。

    Ion source section for ion implantation equipment
    6.
    发明授权
    Ion source section for ion implantation equipment 失效
    离子注入设备的离子源部分

    公开(公告)号：US07521694B2

    公开(公告)日：2009-04-21

    申请号：US11194594

    申请日：2005-08-01

    Applicant: Kwang-Ho Cha

    Inventor： Kwang-Ho Cha

    IPC: H01J27/00

    CPC classification number: H01J37/08 ,  H01J27/024 ,  H01J37/3171 ,  H01J2237/061 ,  H01J2237/083

    Abstract: An ion source section of ion implantation equipment for ionizing reaction gas in an ion implantation process of semiconductor manufacturing processes is disclosed. The ion source section includes a source aperture member separable from an arc chamber and having an ion-discharging hole through which the ion beam discharges. The source aperture member consists of a first plate, a second plate adjacent to the first plate and facing the arc chamber, and a third plate to protect the exposed second plate from the ionized reaction gas.

    Abstract translation: 公开了一种用于在半导体制造工艺的离子注入工艺中离子化反应气体的离子注入设备的离子源部分。 离子源部分包括可与电弧室分离并具有离子放电孔的源极孔部件，离子束通过该离子放电孔排出。 源孔径构件包括第一板，与第一板相邻并面向电弧室的第二板，以及用于保护暴露的第二板免于电离反应气体的第三板。

    Ion source section for ion implantation equipment
    7.
    发明申请
    Ion source section for ion implantation equipment 失效

    公开(公告)号：US20060022144A1

    公开(公告)日：2006-02-02

    申请号：US11194594

    申请日：2005-08-01

    Applicant: Kwang-Ho Cha

    Inventor： Kwang-Ho Cha

    IPC: H01J27/00

    CPC classification number: H01J37/08 ,  H01J27/024 ,  H01J37/3171 ,  H01J2237/061 ,  H01J2237/083

    Abstract: An ion source section of ion implantation equipment for ionizing reaction gas in an ion implantation process of semiconductor manufacturing processes is disclosed. The ion source section includes a source aperture member separable from an arc chamber and having an ion-discharging hole through which the ion beam discharges. The source aperture member consists of a first plate, a second plate adjacent to the first plate and facing the arc chamber, and a third plate to protect the exposed second plate from the ionized reaction gas.

    Device and method for detecting the drive state of a turbo pump in a tandetron accelerator of an ion implantation device
    8.
    发明授权
    Device and method for detecting the drive state of a turbo pump in a tandetron accelerator of an ion implantation device 失效
    用于检测离子注入装置的tandetron加速器中的涡轮泵的驱动状态的装置和方法

    公开(公告)号：US06717165B2

    公开(公告)日：2004-04-06

    申请号：US09963481

    申请日：2001-09-27

    Applicant: Kwang-Ho Cha

    Inventor： Kwang-Ho Cha

    IPC: G02B2700

    CPC classification number: F04D27/008 ,  H01J2237/1825 ,  H01J2237/31701

    Abstract: A technique is disclosed for detecting a turbo pump drive state in a tendetron accelerator that accelerates an ion beam to implant ions onto a semiconductor wafer. In particular the method of detecting a turbo pump driving state in the accelerator includes the steps of detecting a current applied to the turbo pump in the accelerator; converting the detected current to an optical signal to transmit it through an optical fiber; converting the optical signal transmitted through the optical fiber to an electric signal; displaying the current value of the converted electric signal; comparing the current value of the converted electric signal with a setting current value to generate an interlocking signal when the current value is out of a given range of the setting current value; and cutting off a power supply of the tendetron accelerator in accordance with the interlocking signal.

    Abstract translation: 公开了一种用于检测在加速离子束以将离子注入到半导体晶片上的倾斜加速器中的涡轮泵驱动状态的技术。 特别地，在加速器中检测涡轮泵驱动状态的方法包括以下步骤：检测在加速器中施加到涡轮泵的电流; 将检测到的电流转换为光信号以通过光纤传输; 将通过光纤传输的光信号转换为电信号; 显示转换的电信号的当前值; 将所述转换后的电信号的当前值与设定电流值进行比较，以在当前值在所述设定电流值的给定范围之外时产生互锁信号; 并根据互锁信号切断倾斜加速器的电源。

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