公开(公告)号：US20130240375A1

公开(公告)日：2013-09-19

申请号：US13783807

申请日：2013-03-04

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Stephen Patrick BLYTHE ,  Marco F. CARDOSI ,  Andrew GILL ,  Leanne MILLS ,  Christopher Philip LEACH

IPC: C12Q1/00

CPC classification number: G01N27/3274 ,  C12Q1/006 ,  G01N27/3271

Abstract: The method includes: providing a test strip comprising a reference electrode and a working electrode coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.

Abstract translation: 该方法包括：提供包括参考电极和涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

公开(公告)号：US20150068920A1

公开(公告)日：2015-03-12

申请号：US14546322

申请日：2014-11-18

Applicant: LifeScan Scotland Limited

Inventor： James Iain RODGERS ,  Leanne MILLS ,  Marco F. CARDOSI ,  Christopher Philip LEACH ,  James MOFFAT

IPC: G01N27/327

CPC classification number: G01N27/3274

Abstract: Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.

Abstract translation: 本文描述和示出了具有仪表和测试条的一个示例性方法和测量系统。 测试条具有第一工作电极，参考电极和第二工作电极。 在该方法中，使用来自已知第一电流和已知第二电流的可接受的填充数据来预测在测试序列期间接近第二时间段（对于给定批次的测试条）的估计的第二电流。 然后在实际测试期间，将接近第二时间间隔的估计的第二电流与接近第二时间间隔的测量的实际第二电流进行比较，以确定测量的实际第二电流是否基本上等于或在与估计的 以确定测试条中的生理液体样本的足够体积。

公开(公告)号：US20130037421A1

公开(公告)日：2013-02-14

申请号：US13648979

申请日：2012-10-10

Applicant: LifeScan Scotland Limited

Inventor： Marco F. CARDOSI ,  Stephen Patrick Blythe ,  Matthew Finch ,  Arlene Thompson ,  Nina Antonia Naylor ,  Eric Jason Bailey ,  Michael Patrick Dolan ,  Gretchen Anderson ,  Lorraine Comstock ,  Mary McEvoy ,  Thomas Sutton ,  Richard Michael Day ,  Leanne Mills ,  Emma Vanessa Jayne Day ,  Christopher Philip Leach

IPC: C12Q1/26 ,  G01N27/416

CPC classification number: G01N27/3274

Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.

Abstract translation: 提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。 在一个示例中，提供了包括测试条和测试仪的分析物测量系统。 测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。 测试仪包括电子电路和信号处理器。 电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。 所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量 低于施加到电极的测试电压。