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1.发明授权公开(公告)号：US10161852B2
公开(公告)日：2018-12-25
申请号：US15594967
申请日：2017-05-15
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz , Rick Cooper
Abstract: A system for emitting and detecting electromagnetic radiation of multiple wavelengths to observe the motion of particles in a polydisperse solution in order to size the particles is provided. The system includes a first and second light sources constructed to emit a first and second beams of electromagnetic radiation at substantially a first and second wavelength, respectively. The beams are directed to a specimen chamber such that a portion of the beams scatter when illuminating the particles, and wherein the scattered portion of the beams are directed to a sensor. The first and second wavelengths are different from each other and a recorder is connected to the sensor. At processor controls the light sources in a time-division fashion, and from the resulting images the size of particles can be determined by tracking the motion of the particles.
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2.发明申请公开(公告)号：US20170122860A1
公开(公告)日：2017-05-04
申请号：US15293180
申请日：2016-10-13
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz , Monette Karr
CPC classification number: G01N15/1463 , G01N13/00 , G01N15/0205 , G01N21/51 , G01N2015/0038 , G01N2015/0053 , G01N2015/0092 , G01N2015/0277 , G01N2021/513 , G01N2201/061 , G01N2201/12
Abstract: A system for determining the growth/dissolution rate of colloidal particles is disclosed and includes multiple light sources and multiple sensors. A light source is constructed to emit a beam of electromagnetic radiation at a specimen chamber that holds the colloidal particles. The chamber allows a portion of the combined beam to scatter perpendicularly or at some other angle to the combined beam. The scattered portion of the beam is directed to a sensor that detects electromagnetic radiation. The sensor is connected to processor that activates the light source and obtains an image from the sensor. Multiple images are taken at a time interval and for each image taken, and a total image intensity level is calculated and normalized. A formula is then calculated that fits the normalized values over time and a slope is determined from the formula.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20170370825A1
公开(公告)日：2017-12-28
申请号：US15399679
申请日：2017-01-05
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz , Rick Cooper
CPC classification number: G01N21/03 , G01N15/1404 , G01N15/1436 , G01N15/1463 , G01N2015/0038
Abstract: A special purpose cuvette assembly with features that create a small, restricted volume to minimize bulk movements of liquid and that minimize backscattering of light. The special-purpose cuvette assembly enables recording of Brownian movements of nanoparticles in a liquid when it is placed in a suitable optical device comprising a light sheet and an optical microscope attached to a video camera that is oriented perpendicular to the light-sheet plane.
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公开(公告)号：US09857283B1
公开(公告)日：2018-01-02
申请号：US15634858
申请日：2017-06-27
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz
CPC classification number: G01N15/1012 , G01N15/0211 , G01N15/0227 , G01N15/1463 , G01N21/51 , G01N2015/0038 , G01N2015/0053 , G01N2015/1486 , G01N2021/513 , G01N2201/127 , G02B21/06 , G02B21/365 , H04N7/181
Abstract: A method for calibrating a dark field microcopy setup is disclosed. The method includes preparing a plurality of particle samples, each with a known concentration and particle size, the plurality having more than one particle size and, optionally, more than one refractive index and more than one diluent. For each sample in the plurality, the sample is measured in the setup and the scattered light intensity and number of particles is measured. From this data, a relationship between the scattered light intensity, particle size and calibrated investigated volume can be determined. The calibrated investigated volume is used to obtain the proper particle size distribution in a given diluent.
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公开(公告)号：US20180003610A1
公开(公告)日：2018-01-04
申请号：US15634858
申请日：2017-06-27
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz
CPC classification number: G01N15/1012 , G01N15/0211 , G01N15/0227 , G01N15/1463 , G01N21/51 , G01N2015/0038 , G01N2015/0053 , G01N2015/1486 , G01N2021/513 , G01N2201/127 , G02B21/06 , G02B21/365 , H04N7/181
Abstract: A method for calibrating a dark field microcopy setup is disclosed. The method includes preparing a plurality of particle samples, each with a known concentration and particle size, the plurality having more than one particle size and, optionally, more than one refractive index and more than one diluent. For each sample in the plurality, the sample is measured in the setup and the scattered light intensity and number of particles is measured. From this data, a relationship between the scattered light intensity, particle size and calibrated investigated volume can be determined. The calibrated investigated volume is used to obtain the proper particle size distribution in a given diluent.
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6.发明申请公开(公告)号：US20170343469A1
公开(公告)日：2017-11-30
申请号：US15594967
申请日：2017-05-15
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz , Rick Cooper
CPC classification number: G01N21/0303 , G01N15/0211 , G01N2015/0038 , G01N2015/0053 , G01N2021/0307
Abstract: The system and cuvette insert is disclosed where the insert has a top surface that includes a first and second vertical channel opening. A first vertical channel extends downwardly from the first vertical channel opening and a second vertical channel extending from the second vertical channel opening. The insert also has a side wall into which the viewing chamber is formed. The viewing chamber has an upper viewing chamber wall and a lower viewing chamber wall. These walls define the viewing chamber and may be substantially parallel to the floor of the cuvette into which the insert is inserted. At the end of the viewing chamber is a reflecting wall. The viewing chamber has two ends, with one end in fluid connection with the first vertical channel and the other end in fluid connection with the second vertical channel. The fluid connection between the viewing chamber and the first vertical channel may also include a first lateral channel. Likewise the fluid connection between the viewing chamber and the second vertical channel may include a second lateral channel.
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7.发明授权公开(公告)号：US10012580B2
公开(公告)日：2018-07-03
申请号：US15293180
申请日：2016-10-13
Applicant: MANTA Instruments, Inc.
Inventor： Jan J. Tatarkiewicz , Monette Karr
CPC classification number: G01N15/1463 , G01N13/00 , G01N15/0205 , G01N21/51 , G01N2015/0038 , G01N2015/0053 , G01N2015/0092 , G01N2015/0277 , G01N2021/513 , G01N2201/061 , G01N2201/12
Abstract: A system for determining the growth/dissolution rate of colloidal particles is disclosed and includes multiple light sources and multiple sensors. A light source is constructed to emit a beam of electromagnetic radiation at a specimen chamber that holds the colloidal particles. The chamber allows a portion of the combined beam to scatter perpendicularly or at some other angle to the combined beam. The scattered portion of the beam is directed to a sensor that detects electromagnetic radiation. The sensor is connected to processor that activates the light source and obtains an image from the sensor. Multiple images are taken at a time interval and for each image taken, and a total image intensity level is calculated and normalized. A formula is then calculated that fits the normalized values over time and a slope is determined from the formula.
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