公开(公告)号：US20190041345A1

公开(公告)日：2019-02-07

申请号：US16158043

申请日：2018-10-11

Applicant: MEDTRONIC MINIMED, INC.

Inventor： KEITH NOGUEIRA ,  TALY G. ENGEL ,  XIAOLONG LI ,  BRADLEY C. LIANG ,  RAJIV SHAH ,  JAEHO KIM ,  MIKE C. LIU ,  ANDY Y. TSAI ,  ANDREA VARSAVSKY ,  FEI YU

IPC: G01N27/02 ,  G01N27/416 ,  G01N33/49 ,  G01N33/487

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20170209082A1

公开(公告)日：2017-07-27

申请号：US15483404

申请日：2017-04-10

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  XIAOLONG LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  C12Q1/00 ,  A61M5/172 ,  G01N21/59 ,  G01N27/416 ,  G01N27/327 ,  A61B5/1495 ,  A61M5/142

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20210161439A1

公开(公告)日：2021-06-03

申请号：US17175146

申请日：2021-02-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  XIAOLONG LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170150911A1

公开(公告)日：2017-06-01

申请号：US15428589

申请日：2017-02-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： ANDREA VARSAVSKY ,  Xiaolong LI ,  MIKE C. LIU ,  YUXIANG ZHONG ,  NING YANG

IPC: A61B5/145 ,  A61B5/1468 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.