公开(公告)号：US20250033055A1

公开(公告)日：2025-01-30

申请号：US18294719

申请日：2022-08-02

Applicant: MGI Tech Co., Ltd.

Inventor： Kee Tsz Woo ,  Michelle Jarrell ,  Paul Lundquist ,  Jay Shafto

IPC: B01L3/00 ,  C12Q1/6874

Abstract: A nucleic acid sequencing system may include a substrate including a three-dimensionally patterned surface. The three-dimensionally patterned surface may define nanowells each including a derivitized area for binding to nucleic acid template molecules. The nanowells may be 100 nm in diameter with 350 nm center-to-center spacing. The substrate may including reflective layers and plasmonically enhanced layers for increasing fluorescent signals during nucleic acid sequencing.

公开(公告)号：US20230381782A1

公开(公告)日：2023-11-30

申请号：US18249563

申请日：2021-11-02

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Joon Yang ,  Jon Bartman ,  Chintang Yen ,  Razvan Chirita ,  Kee Tsz Woo ,  Jay Shafto ,  Michelle Jarrell ,  Wei Wang

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/0841 ,  B01L2300/0636

Abstract: A nucleic acid sequencing system may include non-planar substrates coupled to the outer surface of a rotating drum. The substrates may be curved and include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the non-planar substrate while the non-planar substrate is rotated relative to the detection system around a longitudinal axis of the drum by the actuation system.

公开(公告)号：US20220403466A1

公开(公告)日：2022-12-22

申请号：US17839829

申请日：2022-06-14

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Chintang Yen ,  Andriy Tspuryk ,  Joon Yang ,  Jon Bartman ,  Razvan Chirita ,  Jay Shafto ,  Michelle Jarrell ,  Wei Wang ,  Clark Reyes

IPC: C12Q1/6874 ,  B01L3/00 ,  G01N21/64

Abstract: A nucleic acid sequencing system may include a substrate coupled to a rotating disk. The substrate may include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the substrate while the substrate is rotated relative to the detection system around a rotational axis of the substrate, perpendicular to a surface of the substrate, by the actuation system.