公开(公告)号：US12235216B2

公开(公告)日：2025-02-25

申请号：US17798786

申请日：2020-02-12

Applicant: MGI Tech Co., Ltd.

Inventor： Heming Jiang ,  Yi Huang ,  Qian Deng ,  Bin Yang ,  Xin Wen ,  Mingyou Cao ,  Yanqiao Huang ,  Ziyi Wu ,  Craig Edward Uhrich ,  Brian Keith Hauser ,  Chintang Yen

IPC: G01N21/64

Abstract: An optical imaging system (1) is configured for photographing a sample and includes a lighting module (11) and an imaging module (15). The lighting module (11) is configured for outputting excitation light, the excitation light is configured to excite the sample to generate excited light, the imaging module (15) comprises a time delay integration line scan camera (151), the time delay integration line scan camera (151) is configured to record the excited light. A biochemical substance detection system using the optical imaging system (1) is also provided, improving the detection flux.

公开(公告)号：US20230051226A1

公开(公告)日：2023-02-16

申请号：US17879075

申请日：2022-08-02

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Craig Ulrich ,  Razvan Chirita ,  Andriy Tspuryk ,  Chintang Yen

IPC: G01N21/03 ,  G01N21/05

Abstract: Double sided flow cell and other substrate imaging systems, such as imaging systems used in nucleic acid sequencing and similar processes. In one example, the imaging system includes a flipper to facilitate imaging different surfaces of the flow cell or other substrate. In another example, the imaging system includes two optical systems for imaging different surfaces of the flow cell or other substrate. In another example, the imaging system is an immersion system. In these and other examples, the system may include an auto-focus sub-system configured to accurately focus the optics on one surface of the double sided flow cell without interference from the other surface of the flow cell.

公开(公告)号：US20230381782A1

公开(公告)日：2023-11-30

申请号：US18249563

申请日：2021-11-02

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Joon Yang ,  Jon Bartman ,  Chintang Yen ,  Razvan Chirita ,  Kee Tsz Woo ,  Jay Shafto ,  Michelle Jarrell ,  Wei Wang

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/0841 ,  B01L2300/0636

Abstract: A nucleic acid sequencing system may include non-planar substrates coupled to the outer surface of a rotating drum. The substrates may be curved and include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the non-planar substrate while the non-planar substrate is rotated relative to the detection system around a longitudinal axis of the drum by the actuation system.

公开(公告)号：US20220403466A1

公开(公告)日：2022-12-22

申请号：US17839829

申请日：2022-06-14

Applicant: MGI Tech Co., Ltd.

Inventor： Paul Lundquist ,  Chintang Yen ,  Andriy Tspuryk ,  Joon Yang ,  Jon Bartman ,  Razvan Chirita ,  Jay Shafto ,  Michelle Jarrell ,  Wei Wang ,  Clark Reyes

IPC: C12Q1/6874 ,  B01L3/00 ,  G01N21/64

Abstract: A nucleic acid sequencing system may include a substrate coupled to a rotating disk. The substrate may include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the substrate while the substrate is rotated relative to the detection system around a rotational axis of the substrate, perpendicular to a surface of the substrate, by the actuation system.